Results 111 to 120 of about 48,310 (191)

Tempol Induces Oxidative Stress, ER Stress and Apoptosis via MAPK/Akt/mTOR Pathway Suppression in HT29 (Colon) and CRL-1739 (Gastric) Cancer Cell Lines. [PDF]

Curr Issues Mol Biol
Ozdemir G, Kaplan HM.
europepmc   +1 more source

Phloridzin as a Nutraceutical for Cancer Prevention and Therapy: A Comprehensive Review of Its Mechanisms, Bioavailability Challenges and Future Applications

Food Science &Nutrition, Volume 13, Issue 8, August 2025.
Phloridzin, a bioactive flavonoid from Malus species, demonstrates diverse therapeutic effects including anticancer, antidiabetic, hepatoprotective, cardioprotective, neuroprotective, and antimicrobial activities. Its anticancer efficacy is mediated through glucose transporter inhibition and modulation of oncogenic signaling pathways.
Praveen Dhyani, Priyanka Sati, Dharam Chand Attri, Eshita Sharma, Ruchi Soni, Javad Sharifi‐Rad, Daniela Calina   +6 more
wiley   +1 more source

Correlations Between Immunophenotypic Markers and Clinical Progression in Romanian Patients Diagnosed with Diffuse Large B-Cell Lymphoma. [PDF]

Medicina (Kaunas)
Halcu G, Evsei-Seceleanu A, Tapoi DA, Cerbu M, Barta C, Ceausu MC.   +5 more
europepmc   +1 more source

Impacts of Inorganic Arsenic Exposure on Genetic Stability of Human Mesenchymal Stromal Cells

Journal of Applied Toxicology, Volume 45, Issue 8, Page 1555-1571, August 2025.
ABSTRACT Human mesenchymal stem/stromal cells (hMSCs) can differentiate into mesoderm‐type cells, making them suitable candidates for tissue repair therapies. However, their relatively low frequency in adult tissue necessitates ex vivo expansion prior to regenerative medicine applications, and therefore, long‐term hMSC genetic stability during ...
Marc A. Beal, Melanie Coughlan, Andrée Nunnikhoven, Reena Corbane, Cathy Cummings‐Lorbetskie, Andrea Rowan‐Carroll, Tanvi Sharma, Andrew Williams, Jessie R. Lavoie, Andrew Stalker, Asish Mohapatra, Matthew J. Meier   +11 more
wiley   +1 more source

APG-115 synergizes with bortezomib to induce apoptosis in cervical cancer cells. [PDF]

Anticancer Drugs
Sun C, Meng X, Cui X, Liang S, Sun J, Zhang B, Cui Y, Zhao Y, Chen N, Tian K, Chen Y.   +10 more
europepmc   +1 more source

Paternally Expressed Gene 10 Promoter Methylation Level as a Predictor of HBeAg Seroconversion in Chronic Hepatitis B Patients

Journal of Medical Virology, Volume 97, Issue 8, August 2025.
ABSTRACT The management of chronic hepatitis B (CHB) encounters challenges like suboptimal antiviral response and the lack of predictive biomarkers. In this study, the role of paternally expressed gene 10 (PEG10) in hepatitis B e antigen (HBeAg) seroconversion (HBeAg SC) was explored to identify a therapeutic target and predictive model.
Pengyu Luo, Nan Chen, Yuna Tang, Jing Wang, Pei Liu, Yuchen Fan, Huihui Liu, Kai Wang   +7 more
wiley   +1 more source

Mechanisms of Erythropoietin-Mediated Protection Against Retinal Ganglion Cell Apoptosis. [PDF]

Med Sci Monit
Chen W, Lao W, Chen Y, Liang X.
europepmc   +1 more source

Osteoarthritis: Mechanisms and Therapeutic Advances

MedComm, Volume 6, Issue 8, August 2025.
A schematic illustration of the pathogenesis and emerging therapeutic strategies for OA, including: risk factors and molecular mechanisms of OA, joint changes between healthy and OA conditions, and current emerging therapeutic approaches for OA. Abbreviations: IA: intra‐articular injection; EVs: extracellular vesicles. ABSTRACT Osteoarthritis (OA) is a
Wei Liu, Ning‐Yi Guo, Jian‐Quan Wang, Bing‐Bing Xu   +3 more
wiley   +1 more source

MYBL2 promotes cell proliferation and inhibits cell apoptosis via PI3K/AKT and BCL2/BAX/Cleaved-caspase-3 signaling pathway in gastric cancer cells. [PDF]

Sci Rep
Chen J, Ji Z, Wu D, Wei S, Zhu W, Peng G, Hu M, Zhao Y, Wu H.   +8 more
europepmc   +1 more source

Polypharmacology‐Driven Discovery of ZAK‐I‐57: A Potent Multi‐Targeted Benzoxazinone Small Molecule for Hepatocellular Carcinoma Therapy

MedComm, Volume 6, Issue 8, August 2025.
ABSTRACT Hepatocellular carcinoma (HCC) is a deadly disease characterized by a high mortality rate and resistance to conventional therapies, highlighting the need for novel therapeutic interventions. Given the multifaceted nature of HCC pathogenesis, a multitargeted and polypharmacological approach is crucial for effective treatment. This study reports
Shakeel Ahmad Khan, Huihai Yang, Fan Ying, Chin Ngok Chu, Terence Kin Wah Lee   +4 more
wiley   +1 more source