Results 121 to 130 of about 60,057 (198)
Dual Targeting of Pim and PI3 Kinases in Mature T‐Cell Lymphoma
European Journal of Haematology, Volume 115, Issue 1, Page 82-95, July 2025.ABSTRACT Provirus Integration site for Moloney leukemia virus (Pim) family members are well‐known oncogenes, with an expression that is restricted to few cell types including hematopoietic cells in adult organisms, making it a promising target for lymphoma treatment.
M. Lohrberg +13 more
wiley +1 more source
Molecular Oncology, Volume 19, Issue 6, Page 1687-1706, June 2025.Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy +12 more
wiley +1 more source
TP53 ‐Mutated Myeloid Neoplasms: 2024 Update on Diagnosis, Risk‐Stratification, and Management
American Journal of Hematology, Volume 100, Issue S4, Page 88-115, June 2025.ABSTRACT Alterations in the tumor suppressor gene TP53 are common in human cancers and are associated with an aggressive nature. Approximately 8%–12% of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) harbor TP53 mutations (TP53 mut) and present immense challenges due to inherent chemoresistance and poor outcomes.
Mithun Vinod Shah +2 more
wiley +1 more source
The proto-oncogene Bcl-2 and its role in regulating apoptosis
Nature Network Boston, 1997 G. Kroemer
semanticscholar +2 more sources
Targeted Therapies in Myelofibrosis: Present Landscape, Ongoing Studies, and Future Perspectives
American Journal of Hematology, Volume 100, Issue S4, Page 30-50, June 2025.ABSTRACT Myelofibrosis (MF) is a myeloproliferative neoplasm that is accompanied by driver JAK2, CALR, or MPL mutations in more than 90% of cases, leading to constitutive activation of the JAK–STAT pathway. MF is a multifaceted disease characterized by trilineage myeloid proliferation with prominent megakaryocyte atypia and bone marrow fibrosis, as ...
Giuseppe G. Loscocco, Paola Guglielmelli
wiley +1 more source
Recent Findings in N6‐Methyladenosine Modification and Significance in Pancreatic Cancer
Cancer Medicine, Volume 14, Issue 11, June 2025.ABSTRACT Background RNA modifications are widely detected in cells and are involved in RNA structural stabilization and regulation of gene expression. In cancer cells, RNA modifications are altered, resulting in abnormal expression of numerous genes and promoting cancer growth. N1‐methyladenosine (m1A), N6‐methyladenosine (m6A), N3‐methylcytosine (m3C),
Tomoaki Hara +8 more
wiley +1 more source
PUF60‐Regulated Isoform Switching of MAZ Modulates Gastric Cancer Cell Migration
Cancer Medicine, Volume 14, Issue 11, June 2025.ABSTRACT Background As an essential transcription factor, Myc‐associated zinc‐finger protein (MAZ) is frequently upregulated in many human tumors and is a well‐documented oncogene. However, we found high expression of MAZ was closely associated with good survival outcomes in patients with stomach adenocarcinoma (STAD), and the underlying mechanism ...
Dong Xing +14 more
wiley +1 more source
Cancer Medicine, Volume 14, Issue 11, June 2025.ABSTRACT Background Breast cancer is the most common malignant tumor among women. Recent studies have found that gut probiotics and their metabolic products play a significant role in activating the immune system, reshaping the tumor microenvironment, and inhibiting cancer progression.
Xiaowei Li +11 more
wiley +1 more source
Selenium Nanoparticles in Cancer Therapy: Unveiling Cytotoxic Mechanisms and Therapeutic Potential
Cancer Reports, Volume 8, Issue 6, June 2025.ABSTRACT Background Cancer represents a complex group of diseases characterized by abnormal cell proliferation, invasion, and metastasis. These features pose significant challenges to conventional therapeutic approaches, necessitating the development of more targeted and effective treatment strategies.
Sumaira Anjum +6 more
wiley +1 more source