Results 121 to 130 of about 48,310 (191)

The cardioprotective effects of acteoside in myocardial ischemia reperfusion injury and the underlying mechanism. [PDF]

BMC Cardiovasc Disord
Li J, Guo Y, Yang Y, Xue Q, Cao H, Yang G, Sun Z, Jia LL, Yu HB.   +8 more
europepmc   +1 more source

PI3K/AKT/mTOR Axis in Cancer: From Pathogenesis to Treatment

MedComm, Volume 6, Issue 8, August 2025.
The PI3K/AKT/mTOR signaling axis is crucial in cancer progression, regulating cell growth, survival, and metabolism. Often hyperactivated through mutations or loss of tumor suppressors such as PTEN, this pathway promotes cancer cell proliferation and survival by inhibiting apoptosis and activating mTOR, which drives protein synthesis and suppresses ...
Mingyang Jiang, Ke Zhang, Zhenwang Zhang, Xinran Zeng, Zihang Huang, Peizhuo Qin, Zhilin Xie, Xue Cai, Milad Ashrafizadeh, Yu Tian, Ruqiong Wei   +10 more
wiley   +1 more source

Dexmedetomidine mitigates oxidative stress in H9C2 cardiac myoblasts under a high‑glucose environment via the PI3K/AKT signaling pathway. [PDF]

Mol Med Rep
Qu Y, Xiong W, Zhou R, Song N, Qian J.
europepmc   +1 more source

The potential of NAT10‐mediated ac4C acetylation in clinical translation

Clinical and Translational Discovery, Volume 5, Issue 4, August 2025.
Xuqiao Mei, Wanxin Duan, Jiawei Hu, Shisiyu Zheng, Yuhuang Xu, Yongguang Zhang, Jianming Weng, Xiao Yang   +7 more
wiley   +1 more source

Macrophages: Subtypes, Distribution, Polarization, Immunomodulatory Functions, and Therapeutics

MedComm, Volume 6, Issue 8, August 2025.
Macrophages originate from the yolk sac, fetal liver, and bone marrow, differentiating into two main subtypes: M1‐like (proinflammatory) and M2‐like (anti‐inflammatory). These subtypes exhibit high plasticity, allowing them to transform in response to environmental cues or therapeutic interventions.
Mengyuan Peng, Niannian Li, Hongbo Wang, Yaxu Li, Hui Liu, Yanhua Luo, Bao Lang, Weihang Zhang, Shilong Li, Liujun Tian, Bin Liu   +10 more
wiley   +1 more source

IQGAP1 participates in endothelial cell apoptosis and regulates atherosclerosis by targeting YAP. [PDF]

PLoS One
Huang S, Cheng Y, Zhang C.
europepmc   +1 more source

Toll‐Like Receptors in the Immunotherapy Era: Dual‐Edged Swords of Tumor Immunity and Clinical Translation

MedComm, Volume 6, Issue 8, August 2025.
This review discussed the signaling pathways of Toll‐like receptors in tumors and their antitumor or protumor regulatory effects in diverse tumors. We also paid attention to the application of Toll‐like receptors in clinical treatment and summarized the clinical trial situation in recent years.
Nueraili Maihemuti, Yueli Shi, Kaiyue Zhang, Xinyuan Jiang, Jiahe Chu, Yun Xu, Zhiyong Xu, Kai Wang   +7 more
wiley   +1 more source

Anti-tumor efficacy of RAF/MEK inhibitor VS6766 in KRAS-mutated colorectal cancer cells. [PDF]

Cancer Chemother Pharmacol
Zhu H, Yan G, Ma J, Zhang B, Yan Y, Zhu L, Dong R, Lin N, Tan B.   +8 more
europepmc   +1 more source

RNA Epigenetics in Cancer: Current Knowledge and Therapeutic Implications

MedComm, Volume 6, Issue 8, August 2025.
RNA epigenetics regulates cancer through RNA modifications, splicing, transport, and translation. Key components include m⁶A writers, splicing factors, RBPs, and nuclear export machinery. Aberrant RNA metabolism drives tumor progression and immune evasion.
Shanhe Huang, Zonglin Li, Weilong Lin, Ruihui Xie, Hai Huang   +4 more
wiley   +1 more source

Pim kinases in hematological malignancies: where are we now and where are we going? [PDF]

, 2014
Michael Mian, Patrizia Mondello, Salvatore Cuzzocrea   +2 more
core   +1 more source