Results 131 to 140 of about 60,057 (198)

Antisenescence therapies for age‐related bone loss: Target factors, medicines, biomedical materials

Clinical and Translational Medicine, Volume 15, Issue 6, June 2025.
With extended lifespans causing population aging, bone aging has become a worldwide issue. Cellular senescence in the bone microenvironment causes bone degeneration and dysfunction. This review summarises targets in cellular senescence and bone aging while detailing potential therapeutic strategies, including novel medicines and innovative biomedical ...
Qiyue Zhu, Menglong Hu, Likun Wu, Erfan Wei, Xingtong Pan, Hao Liu, Yunsong Liu   +6 more
wiley   +1 more source

Closing the Phenotypic Gap between Transformed Neuronal Cell Lines in Culture and Untransformed Neurons [PDF]

Studies of neuronal dysfunction in the central nervous system (CNS) are frequently limited by the failure of primary neurons to propagate in vitro. Neuronal cell lines can be substituted for primary cells but they often misrepresent normal conditions. We
HonerzuBentrup, Kerstin, Kaushal, Deepak, Myers, Tereance A., Nelman-Gonzales, Mayra, Nickerson, Cheryl A., Ott, C. Mark, Philipp, Mario T., Pierson, Duane L., Ramamurthy, Rajee   +8 more
core   +1 more source

Targeting the MDK/c‐Myc complex to overcome temozolomide resistance in glioma

Clinical and Translational Medicine, Volume 15, Issue 6, June 2025.
ACT001 disrupts the MDK/c‐Myc complex, enhancing c‐Myc ubiquitination and overcoming temozolomide resistance in glioma. Combining ACT001 with temozolomide synergistically inhibits tumour growth and progression, offering a promising therapeutic strategy for glioma patients, particularly those with high MDK expression.
Xiaonan Xi, Xiaojing Ding, Qianqian Wang, Ning Liu, Bangmao Wang, Genbei Wang, Weilong Zhong, Yaxin Lu   +7 more
wiley   +1 more source

An African swine fever virus gene with similarity to the proto-oncogene bcl-2 and the Epstein-Barr virus gene BHRF1

Journal of Virology, 1993
J. Neilan, Zhiqiang Lu, C. Afonso, G. Kutish, M. Sussman, D. Rock   +5 more
semanticscholar   +1 more source

Pleiotropic Effects of Metformin on the Chemotherapy Response of HPV‐Positive Cancer Cells

Journal of Medical Virology, Volume 97, Issue 6, June 2025.
ABSTRACT Improved treatment strategies for HPV‐positive cancers are urgently required. The viral E6/E7 oncoproteins are essential for the proliferation of HPV‐positive cancer cells and considered attractive therapeutic targets. Metformin is proposed to be repurposed for cancer therapy, but this is under controversial debate.
Alicia Avenhaus, Bianca J. Kuhn, Milica Velimirović, Tobias D. Strobel, Julia Bulkescher, Claudia Lohrey, Jeroen Krijgsveld, Felix Hoppe‐Seyler, Karin Hoppe‐Seyler   +8 more
wiley   +1 more source

Beyond Conventional Approaches: The Revolutionary Role of Nanoparticles in Breast Cancer

MedComm – Biomaterials and Applications, Volume 4, Issue 2, June 2025.
This review explores integrated approach of nanotechnology to breast cancer diagnosis and treatment. We highlight imaging techniques for tumor detection and biomarker analysis in biological samples for early diagnosis. Advanced therapies, including targeted drug delivery and antibody‐drug conjugates, enable precise medication transport to cancer cells,
Mohan Liu, Yusi Wang, Yan Li, Yibing Zhang, Bailing Zhou, Lei Yang, Xi Yan, Li Yang   +7 more
wiley   +1 more source

CtBP2 Regulates Wnt Signal Through EGR1 to Influence the Proliferation and Apoptosis of DLBCL Cells

Molecular Carcinogenesis, Volume 64, Issue 6, Page 959-969, June 2025.
ABSTRACT Diffuse large B‐cell lymphoma (DLBCL) is the most prevalent form of lymphoma. The overexpression of CtBP2 in tissues may contribute to tumor occurrence and progression. The expression of EGR1 in DLBCL is elevated, suggesting its potential role as an oncogene that promotes the proliferation of DLBCL cells.
Jianfang Dong, Lihua Li, Xuefei Zhang, Xijing Yin, Zucong Chen   +4 more
wiley   +1 more source

Abstracts

Molecular Oncology, Volume 19, Issue S1, Page 1-895, June 2025.
Abstracts submitted to the ‘EACR 2025 Congress: Innovative Cancer Science’, from 16–19 June 2025 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

Lactylation: From Homeostasis to Pathological Implications and Therapeutic Strategies

MedComm, Volume 6, Issue 6, June 2025.
Lactylation, a novel post‐translational modification derived from lactate metabolism, plays a critical role in cellular homeostasis and disease pathogenesis. Under physiological conditions, lactylation regulates gene expression, immune responses, and metabolic adaptation. However, dysregulated lactylation is implicated in various pathological processes,
Xi Chen, Yixiao Yuan, Fan Zhou, Lihua Li, Jun Pu, Yong Zeng, Xiulin Jiang   +6 more
wiley   +1 more source

Mitochondrial Transplantation: A Novel Therapeutic Approach for Treating Diseases

MedComm, Volume 6, Issue 6, June 2025.
This article describes the roles of mitochondria in health and disease and reviews the effects of mitochondrial transplantation in disease, including restoring ATP production, attenuating oxidative stress, modulating inflammatory responses, reducing apoptosis, promoting cell repair, and exhibiting antitumor properties.
Xinglu Miao, Pei Jiang, Zhaoping Wang, Weihua Kong, Lei Feng   +4 more
wiley   +1 more source