Arquivos de Gastroenterologia, 2009 CONTEXT: Esophagogastric junction adenocarcinoma has an aggressive behavior, and TNM (UICC) staging is not always accurate enough to categorize patient's outcome.
Dárcio Matenhauer Lehrbach +5 more
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Is now the time for molecular driven therapy for diffuse large B-cell lymphoma? [PDF]
, 2017 INTRODUCTION: Recent genetic and molecular discoveries regarding alterations in diffuse large B-cell lymphoma (DLBCL) deeply changed the approach to this lymphoproliferative disorder.
Ansuinelli, Michela +4 more
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Bcl-3 deficiency protects against dextran-sodium sulphate-induced colitis in the mouse [PDF]
, 2013 Bcl-3 is a member of the IκB family of proteins and is an essential negative regulator of Toll-like receptor induced responses. Recently, a single nucleotide polymorphism associated with reduced Bcl-3 gene expression has been identified as a potential ...
Araki +26 more
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In silico evidence that protein unfolding is as a precursor of the protein aggregation [PDF]
ChemPhysChem 2020, 21, 377, 2019 We present a computational study on the folding and aggregation of proteins in aqueous environment, as function of its concentration. We show how the increase of the concentration of individual protein species can induce a partial unfolding of the native conformation without the occurrence of aggregates. A further increment of the protein concentration
arxiv +1 more source
A novel methodology on distributed representations of proteins using their interacting ligands [PDF]
Bioinformatics 2018, 2018 The effective representation of proteins is a crucial task that directly affects the performance of many bioinformatics problems. Related proteins usually bind to similar ligands. Chemical characteristics of ligands are known to capture the functional and mechanistic properties of proteins suggesting that a ligand based approach can be utilized in ...
arxiv +1 more source
Early diagnostic value of Bcl-3 localization in colorectal cancer [PDF]
, 2015 B-cell leukemia 3 (Bcl-3) is a member of the inhibitor of κB family, which regulates a wide range of biological processes by functioning as a transcriptional activator or as a repressor of target genes. Elevated expression, sustained nuclear accumulation,
Göran Landberg +6 more
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Mouse skeletal muscle fiber-type-specific macroautophagy and muscle wasting are regulated by a Fyn/STAT3/Vps34 signaling pathway [PDF]
, 2012 Skeletal muscle atrophy induced by aging (sarcopenia), inactivity, and prolonged fasting states (starvation) is predominantly restricted to glycolytic type II muscle fibers and typical spares oxidative type I fibers.
Alessi +49 more
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LINFOMA DE ZONA MARGINAL (MALT) EM GLÂNDULA LACRIMAL - UM RELATO DE CASO
Hematology, Transfusion and Cell Therapy, 2023 Objetivos: O propósito deste estudo é divulgar os conhecimentos sobre um caso raro de linfoma de zona marginal (MALT) em glândula lacrimal, visando ampliar o conhecimento sobre essa doença no meio científico.
PC Gontijo +6 more
doaj
Myc and Mammary Cancer: Myc is a Downstream Effector of the ErbB2 Receptor Tyrosine Kinase [PDF]
, 2016 The proto-oncogene c-myc encodes a transcription factor which plays a major role in the regulation of normal cellular proliferation and is aberrantly expressed in many breast tumors.
Hynes, Nancy, Lane, Heidi
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Targeting BCL-2 regulated apoptosis in cancer [PDF]
, 2018 The ability of a cell to undergo mitochondrial apoptosis is governed by pro- and anti-apoptotic members of the BCL-2 protein family. The equilibrium of pro- versus anti-apoptotic BCL-2 proteins ensures appropriate regulation of programmed cell death ...
Campbell, Kirsteen J. +1 more
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