Genome-wide identification of FoxO-dependent gene networks in skeletal muscle during C26 cancer cachexia [PDF]
, 2014 BACKGROUND: Evidence from cachectic cancer patients and animal models of cancer cachexia supports the involvement of Forkhead box O (FoxO) transcription factors in driving cancer-induced skeletal muscle wasting. However, the genome-wide gene networks and
Beharry, Adam W. +6 more
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Emerging roles of ATF2 and the dynamic AP1 network in cancer [PDF]
, 2010 Cooperation among transcription factors is central for their ability to execute specific transcriptional programmes. The AP1 complex exemplifies a network of transcription factors that function in unison under normal circumstances and during the course ...
A Behrens +228 more
core +1 more source
Systemic activation of activin A signaling causes chronic kidney disease-mineral bone disorder [PDF]
, 2018 The high cardiovascular mortality associated with chronic kidney disease (CKD) is caused in part by the CKD-mineral bone disorder (CKD-MBD) syndrome.
Sugatani, Toshifumi
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Ermittlung der m-RNA-Expressionsmuster der c-jun, c-fos und c-myc Proto-Onkogene nach ex vivo Ballondilatation von Schweinekarotiden mittels semiquantitativer RT-PCR. [PDF]
, 2005 Ziel der Arbeit war die Ermittlung der mRNA Muster dreier Proto-Onkogene nach Ballondilatation in einem serumfreien Modell mit Hilfe einer zu etablierenden semiquantitativen RT PCR ohne die Verwendung radioaktiver oder fluoreszierender Substanzen ...
Alfke, Heiko (Dr.), Steinhagen, Sandra
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The Egr transcription factor family: From signal transduction to kidney differentiation [PDF]
, 1992 Extracellular “signals” in the form of neurotransmitters, growth factors, hormones, and matrix are known to be key modulators of cellular phenotype. These agents lead to the generation of second messenger signals in the plasma membrane and cytosol.
Sukhatme, Vikas P.
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The c-fos serum response element responds to protein kinase C-dependent and -independent signals but not to cyclic AMP [PDF]
, 1988 Transcription of the c-fos proto-oncogene is rapidly induced by serum growth factors. A short c-fos DNA element, the serum response element (SRE), is required for this response to serum.
Gilman, M. Z.
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, 2023 Fos-related antigen-2 (Fra-2) is the most recently discovered member of the Fos family and, by dimerizing with Jun proteins, forms the activator protein 1 (AP-1) transcription factor.
Capece, Marina +6 more
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Transcription and cancer. [PDF]
, 1991 The normal growth, development and function of an organism requires precise and co-ordinated control of gene expression. A major part of this control is exerted by regulating messenger RNA (mRNA) production and involves complex interactions between an ...
Cox, P. M., Goding, C. R.
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Chinese Journal of Lung Cancer, 2010 Background and objective Cyclooxygenases (COX), the key enzymes in the conversion of arachidonic acid (AA) to prostaglandins (PGs), are involved in initiation and progression of cancer.
Xiaohong ZHAO +3 more
doaj +1 more source
Exosome-mediated transfer of miR-222 is sufficient to increase tumor malignancy in melanoma [PDF]
, 2016 BACKGROUND: Growing evidence is showing that metastatic cell populations are able to transfer their characteristics to less malignant cells. Exosomes (EXOs) are membrane vesicles of endocytic origin able to convey their cargo of mRNAs, microRNAs (miRs),
Bellenghi, Maria +9 more
core +5 more sources