The c-fos serum response element responds to protein kinase C-dependent and -independent signals but not to cyclic AMP [PDF]
, 1988 Transcription of the c-fos proto-oncogene is rapidly induced by serum growth factors. A short c-fos DNA element, the serum response element (SRE), is required for this response to serum.
Gilman, M. Z.
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Neuregulin 1-Beta cytoprotective role in AML 12 mouse hepatocytes exposed to pentachlorophenol. [PDF]
, 2006 Neuregulins are a family of growth factor domain proteins that are structurally related to the epidermal growth factor. Accumulating evidence has shown that neuregulins have cyto- and neuroprotective properties in various cell types.
Dorsey, Waneene C +2 more
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Activation of endogenous c-fos proto-oncogene expression by human T-cell leukemia virus type I-encoded p40tax protein in the human T-cell line, Jurkat [PDF]
Journal of Virology, 1989 We examined the ability of the trans-acting factor p40tax of human T-cell leukemia virus type I (HTLV-I), which is thought to be a crucial molecule in T-cell transformation by HTLV-I, to activate expression of a set of endogenous cellular genes related to T-cell proliferation.
K, Nagata +3 more
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Epidermal Growth Factor Stimulation of Stromelysin mRNA in Rat Fibroblasts Requires Induction of Proto-Oncogenes c-fos and c-jun and Activation of Protein Kinase C [PDF]
Molecular and Cellular Biology, 1990 Stromelysin (transin) is a secreted metalloprotease that is transcriptionally induced by a variety of growth factors and oncogenes. We examined the necessity of specific secondary (protein kinase C) and tertiary (c-fos and c-jun protein products) messengers in the transactivation of stromelysin gene expression by epidermal growth factor (EGF).
S E, McDonnell +2 more
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Role of protein kinase C and cyclic adenosine monophosphate in the regulation of tissue-type plasminogen activator, plasminogen activator inhibitor-1, and platelet-derived growth factor mRNA levels in human endothelial cells. Possible involvement of proto-oncogenes c-jun and c-fos. [PDF]
Arteriosclerosis and Thrombosis: A Journal of Vascular Biology, 1991 Activation of protein kinase C leads to a strong induction of tissue-type plasminogen activator (t-PA) expression in endothelial cells. Using endothelial cells from human umbilical vein (HUVECs) and human aorta (HAECs), we have studied this regulation of t-PA and its inhibitor, plasminogen activator inhibitor-1 (PAI-1), at the mRNA level and have ...
Kooistra, T. +7 more
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Spaceflight modulates gene expression in the whole blood of astronauts [PDF]
, 2016 Astronauts are exposed to a unique combination of stressors during spaceflight, which leads to alterations in their physiology and potentially increases their susceptibility to disease, including infectious diseases.
Barrila, Jennifer +7 more
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Chinese Journal of Lung Cancer, 2010 Background and objective Cyclooxygenases (COX), the key enzymes in the conversion of arachidonic acid (AA) to prostaglandins (PGs), are involved in initiation and progression of cancer.
Xiaohong ZHAO +3 more
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Microcystin-leucine arginine causes cytotoxic effects in sertoli cells resulting in reproductive dysfunction in male mice [PDF]
, 2016 2016-2017 > Academic research: refereed > Publication in refereed journal201804_a bcmaVersion of ...
Chen, YB +6 more
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Gill transcriptome response to changes in environmental calcium in the green spotted puffer fish [PDF]
, 2010 Background Calcium ion is tightly regulated in body fluids and for euryhaline fish, which are exposed to rapid changes in environmental [Ca2+], homeostasis is especially challenging. The gill is the main organ of active calcium uptake and therefore plays
Canario, Adelino V. M. +6 more
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A biologia molecular no prognóstico do carcinoma da tireóide
Revista do Colégio Brasileiro de CirurgiõesThis overview examines some selected genetic mechanisms of cancer development. Strong evidence has been accumulated suggesting that alteration in either the struture or activity of proto-oncogene contributes to the development and for the maintenance of ...
Aluizio Soares de Souza Rodrigues
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