Results 11 to 20 of about 34,392 (169)

AIF1+CSF1R+ MSCs, induced by TNF‐α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis

Hepatology, EarlyView., 2022
Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong, Yan Meng, Fei Ye, Xue Yang, Rong Li, Jinghua Jiang, Qiudong Zhao, Lu Gao, Zhipeng Han, Lixin Wei   +9 more
wiley   +1 more source

c‐Rel–dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis

Hepatology, EarlyView., 2022
In response to genotoxic injury, c‐Rel upregulates ATM‐Chk2‐p53 pathway DNA damage proteins to limiting hepatocarcinogenesis. Abstract Background and Aims Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related death. The NF‐κB transcription factor family subunit c‐Rel is typically protumorigenic; however, it has recently been reported as a
Jack Leslie, Jill E. Hunter, Amy Collins, Amelia Rushton, Lauren G. Russell, Erik Ramon‐Gil, Maja Laszczewska, Misti McCain, Marco Y. W. Zaki, Amber Knox, Yixin Seow, Laura Sabater, Daniel Geh, Neil D. Perkins, Helen L. Reeves, Dina Tiniakos, Derek A. Mann, Fiona Oakley   +17 more
wiley   +1 more source

Assessing Long-Term Changes in Endometrial Morphology and Functionality in Dairy Cows With Metritis. [PDF]

Reprod Domest Anim
ABSTRACT This study evaluated the long‐term impact of metritis on endometrial morphology and functionality in dairy cows. Postpartum Holstein cows (n = 107) were enrolled in a cohort study at the University of Idaho Dairy Center. Metritis was diagnosed using a Metricheck device within 12 days in milk (DIM) based on the presence of fetid, watery ...
Rashid MH, Pereira AM, Pereira FNS, Costa MCO, Santos EF, Christensen L, Sexton JA, Ciccarelli M, Williams LB, Binelli M, Waqas MS, de Oliveira EB, Figueiredo CC.   +12 more
europepmc   +2 more sources

Neuregulin 1-Beta cytoprotective role in AML 12 mouse hepatocytes exposed to pentachlorophenol. [PDF]

, 2006
Neuregulins are a family of growth factor domain proteins that are structurally related to the epidermal growth factor. Accumulating evidence has shown that neuregulins have cyto- and neuroprotective properties in various cell types.
Dorsey, Waneene C, Ford, Byron D, Tchounwou, Paul B   +2 more
core   +2 more sources

An approach for the identification of targets specific to bone metastasis using cancer genes interactome and gene ontology analysis [PDF]

, 2012
Metastasis is one of the most enigmatic aspects of cancer pathogenesis and is a major cause of cancer-associated mortality. Secondary bone cancer (SBC) is a complex disease caused by metastasis of tumor cells from their primary site and is characterized ...
A Clauset, A Ergün, A Subramanian, A-L Barabási, A-L Barabási, AH Wyllie, AJ Levine, B Vogelstein, B Weigelt, C Ortutay, C Secondini, CC Harris, CL Bailey, CL Chaffer, CL Smith, D Hanahan, D Hanahan, DH Jones, DJ Watts, DW Huang, E Cerami, E Eden, EK Sloan, F Emmert-Streib, G Bu, G Chen, Ganesh Bagler, GR Mundy, H Jeong, H Rangaswami, H Yu, H-S Wang, H-Y Chuang, J Lascorz, JA Blake, JE Talmadge, JL Dai, K Chu, K Eppert, K Matsumoto, KI Goh, KR Hess, L Freeman, M Cicek, M Smid, MA Yildirim, Matthias Dehmer, ME Higgins, MEJ Newman, MP Joy, MP Valta, MS Virk, NN Batada, P Jia, P Shannon, PF Jonsson, RS Taichman, S Dorogovtsev, S Maslov, S Mathivanan, S Peri, Shikha Vashisht, SR Rittling, SY Rhee, T Gene, T Koreckij, TA Guise, U Brandes, U Stelzl, W Chang, W Kozlow, WC Hahn, X Lu, X Zhang, XH-F Zhang, Y Kang, Y Mishina   +76 more
core   +8 more sources

Fracture healing induces expression of the proto‐oncogene c‐fos in vivo Possible involvement of the Fos protein in osteoblastic differentiation

FEBS Letters, 1991
Here we report marked in vivo expression of the c‐fos gene in the external soft callus (ESC) and periosteal hard callus (PHC) at the fracture site of adult rat tibia. Northern‐blot analysis showed that the ESC expressed a high level of c‐fos mRNA from post‐fracture day 10 to day 28, the time when endochondral ossification progressed, and that the ...
Ohta, Shuichi, Yamamuro, Takao, Lee, Kaechoong, Okumura, Hideo, Kasai, Ryuichi, Hiraki, Yuji, Ikeda, Toshihiko, Iwasaki, Rempei, Kikuchi, Haruki, Konishi, Junji, Shigeno, Chohei   +10 more
openaire   +2 more sources

Bone morphogenetic proteins (BMP‐2 and BMP‐3) induce the late phase expression of the proto‐oncogene c‐fos in murine osteoblastic MC3T3‐E1 cells [PDF]

FEBS Letters, 1992
Here we report that bone morphogenetic proteins 2 and 3 (BMP‐2 and BMP‐3) induced marked expression of c‐fos mRNA in a biphasic manner, i.e. the late phase (48 to 60 h) as well as the immediate‐early phase (0.5 h), in murine osteoblastic MC3T3‐El cells in vitro.
Ohta, Shuichi, Hiraki, Yuji, Shigeno, Chohei, Suzuki, Fujio, Kasai, Ryuichi, Ikeda, Toshihiko, Kohno, Hiroaki, Lee, Kaechoong, Kikuchi, Haruki, Konishi, Junji, Bentz, Hanne, Rosen, David M., Yamamuro, Takao   +12 more
openaire   +2 more sources

The deazaguanine‐derivative, queuine, affects cell proliferation, protein phosphorylation and the expression of the proto oncogenes c‐fos and c‐myc in HeLa cells [PDF]

FEBS Letters, 1990
In higher eukaryotes the hypermodified guanine analogue, queuine (7‐(5‐(((1S,4S,5R)‐4,5‐dihydroxy‐2‐cyclopentene‐1‐yl)amino)‐methyl)‐7‐deazaguanine), occurs free or as modified nucleoside (Q) in the anticodon of specific tRNAs. Fast proliferating tissues and tumors contain considerable amounts of free queuine and Q‐deficient tRNAs.
Langgut, W., Kersten, H.
openaire   +2 more sources

Mathematical model of a telomerase transcriptional regulatory network developed by cell-based screening: analysis of inhibitor effects and telomerase expression mechanisms [PDF]

, 2014
Cancer cells depend on transcription of telomerase reverse transcriptase (TERT). Many transcription factors affect TERT, though regulation occurs in context of a broader network. Network effects on telomerase regulation have not been investigated, though
A Agrawal, A De Cian, A Goltsov, A Graudenzi, A Schonthal, A Subramanian, A Tapias, A Tapias, A von Kriegsheim, A Wuensche, AE Bilsland, AE Bilsland, AE Bilsland, AE Bilsland, Alan E. Bilsland, B Tang, C Jiang, C Lawless, C Torres-Sosa, CJ Anderson, Claire J. Cairney, D Hanahan, D Machado, D Xu, DE Nelson, DG Johnson, DH Crouch, DJ Billingsley, DL Crowe, DR White, E Yang, EJ Black, F Gizard, FW Huang, G Niu, G Wrobel, H Yuan, J Cho, J Grefenstette, J Won, J Zhao, JN Davis, Jon Roffey, JS Ho, K Cho, K Jiang, K Lafferty-Whyte, K Lafferty-Whyte, K Lafferty-Whyte, K Ookawa, K Thalmeier, K Willadsen, Katrina Stevenson, KI Zeller, KJ Wu, KM Ryan, L Chen, L Durant, L Konnikova, LA Bell, LC Freeman, LE Sivak, LG Wooten-Blanks, LI Chen, M Choi, M Daniel, M Kohl, M Nicolas, M Takakura, N Arkus, N Benson, N Kley, OE Akman, OW Rokhlin, P Angel, PJ Killela, PM Neilsen, Q Wang, R Duan, R Schlatter, R Wilds, RT Sitaram, S Horn, S Hossain, S Huang, S Kauffman, S Kyo, S Mangan, S Oh, Satoru Miyano, SM Mac, SP Hsu, Stacey Hoare, SY Lin, T Kanaya, T Maki-Marttunen, T Sengupta, TG Oliver, TH Kim, U Moehren, V Anest, V Batagelj, VJ Gnanapragasam, VK Mootha, W. Nicol Keith, WB Lee, X Chen, Y Xiao, Y Xing, Y Yao, Yu Liu   +110 more
core   +3 more sources

Complex-based analysis of dysregulated cellular processes in cancer [PDF]

, 2014
Background: Differential expression analysis of (individual) genes is often used to study their roles in diseases. However, diseases such as cancer are a result of the combined effect of multiple genes.
Khanna, Kum Kum, Liu, Chao, Madhamshettiwar, Piyush B., Ragan, Mark A., Simpson, Peter T., Song, Sarah, Srihari, Sriganesh   +6 more
core   +1 more source