Results 11 to 20 of about 19,964,650 (157)

TRPA1 Regulates Fibrosis-Associated Transcriptional Pathways in Human Lung Epithelial Cells. [PDF]

Basic Clin Pharmacol Toxicol
ABSTRACT Transient receptor potential ankyrin 1 (TRPA1) is a cation channel originally identified in lung fibroblasts and extensively studied in sensory neurons, where it is associated with pain and neurogenic inflammation. We and others have recently shown that TRPA1 is also expressed in lung epithelial cells and that its expression is regulated by ...
Halonen L, Luostarinen S, Valjus I, Vistbacka J, Pemmari A, Moilanen E.   +5 more
europepmc   +2 more sources

Automated identification of Fos expression [PDF]

, 2001
The concentration of Fos, a protein encoded by the immediate-early gene c-fos, provides a measure of synaptic activity that may not parallel the electrical activity of neurons.
Cherkerzian, S., Ennulat, D.J., Evans, M.L., Ma, J., Cohen, B.M., Lange, N., Young, D., Froimowitz, M.P.   +7 more
core   +4 more sources

The FnBPA from methicillin-resistant Staphylococcus aureus promoted development of oral squamous cell carcinoma

Journal of Oral Microbiology, 2022
Background Oral squamous cell carcinoma (OSCC) is the most common tumor in the oral cavity. Methicillin-resistant Staphylococcus aureus (MRSA) were highly detected in OSCC patients; however, the interactions and mechanisms between drug-resistant bacteria
Li-Xin Kong, Zheng Wang, Yu-Ke Shou, Xue-Dong Zhou, Ya-Wen Zong, Ting Tong, Min Liao, Qi Han, Yan Li, Lei Cheng, Biao Ren   +10 more
doaj   +1 more source

Studies of the Transcriptional Control of the Human c-fos Proto-Oncogene [PDF]

, 1989
The c-fos gene is the cellular counterpart of the transforming genes of several retroviruses. Its transcription and expression is increased in many types of different cells following extra-cellular stimuli, and this increase is both rapid and transient ...
Morgan, Iain Matthew
core   +6 more sources

AIF1+CSF1R+ MSCs, induced by TNF‐α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis

Hepatology, EarlyView., 2022
Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong, Yan Meng, Fei Ye, Xue Yang, Rong Li, Jinghua Jiang, Qiudong Zhao, Lu Gao, Zhipeng Han, Lixin Wei   +9 more
wiley   +1 more source

c‐Rel–dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis

Hepatology, EarlyView., 2022
In response to genotoxic injury, c‐Rel upregulates ATM‐Chk2‐p53 pathway DNA damage proteins to limiting hepatocarcinogenesis. Abstract Background and Aims Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related death. The NF‐κB transcription factor family subunit c‐Rel is typically protumorigenic; however, it has recently been reported as a
Jack Leslie, Jill E. Hunter, Amy Collins, Amelia Rushton, Lauren G. Russell, Erik Ramon‐Gil, Maja Laszczewska, Misti McCain, Marco Y. W. Zaki, Amber Knox, Yixin Seow, Laura Sabater, Daniel Geh, Neil D. Perkins, Helen L. Reeves, Dina Tiniakos, Derek A. Mann, Fiona Oakley   +17 more
wiley   +1 more source

Helicobacter pylori Activates Mitogen-activated Protein Kinase Cascades and Induces Expression of the Proto-oncogenes c-fos and c-jun [PDF]

Journal of Biological Chemistry, 2000
Helicobacter pylori is an etiological agent in the development of mucosa-associated lymphoid tissue lymphoma and gastric adenocarcinoma. Patients infected with H. pylori carry a 3-6-fold increased risk of developing cancer compared with uninfected individuals. H.
Meyer-ter-Vehn, Tobias, Covacci, Antonello, Kist, Manfred, Pahl, Heike-L.   +3 more
openaire   +3 more sources

Proto-oncogene c-fos is transcriptionally regulated by parathyroid hormone (PTH) and PTH-related protein in a cyclic adenosine monophosphate-dependent manner in osteoblastic cells. [PDF]

Endocrinology, 1997
PTH and PTH-related protein (PTHrP) bind to the PTH-1 (PTH/PTHrP) receptor and produce anabolic and catabolic effects in bone. To investigate postreceptor mechanisms of action, MC3T3-E1 cells were induced to differentiate to optimize PTH-1 receptor expression, and differentiated MC3T3-E1 cells were treated with varying doses of PTH (1-34) for 1 h ...
L K, McCauley, A J, Koh, C A, Beecher, T J, Rosol   +3 more
openaire   +3 more sources

Ras-mediated phosphorylation of a conserved threonine residue enhances the transactivation activities of c-Ets1 and c-Ets2 [PDF]

, 1996
The Ras oncogene products regulate the expression of genes in transformed cells, and members of the Ets family of transcription factors have been implicated in this process.
Yang, Beom-Seok, Ostrowski, M C, Hauser, C A, Hauser, Craig A., Van Beveren, Charles, Maki, R A, Yang, B S, Henkel, G, Hume, D A, Ostrowski, Michael C., Colman, M S, Colman, Michael S., Van Beveren, C, Henkel, Gregory, Stacey, K J, Hume, David A., Maki, Richard A., Stacey, Katryn J.   +17 more
core   +1 more source

Fracture healing induces expression of the proto‐oncogene c‐fos in vivo Possible involvement of the Fos protein in osteoblastic differentiation

FEBS Letters, 1991
Here we report marked in vivo expression of the c‐fos gene in the external soft callus (ESC) and periosteal hard callus (PHC) at the fracture site of adult rat tibia. Northern‐blot analysis showed that the ESC expressed a high level of c‐fos mRNA from post‐fracture day 10 to day 28, the time when endochondral ossification progressed, and that the ...
Ohta, Shuichi, Yamamuro, Takao, Lee, Kaechoong, Okumura, Hideo, Kasai, Ryuichi, Hiraki, Yuji, Ikeda, Toshihiko, Iwasaki, Rempei, Kikuchi, Haruki, Konishi, Junji, Shigeno, Chohei   +10 more
openaire   +2 more sources