The deazaguanine‐derivative, queuine, affects cell proliferation, protein phosphorylation and the expression of the proto oncogenes c‐fos and c‐myc in HeLa cells [PDF]
FEBS Letters, 1990 In higher eukaryotes the hypermodified guanine analogue, queuine (7‐(5‐(((1S,4S,5R)‐4,5‐dihydroxy‐2‐cyclopentene‐1‐yl)amino)‐methyl)‐7‐deazaguanine), occurs free or as modified nucleoside (Q) in the anticodon of specific tRNAs. Fast proliferating tissues and tumors contain considerable amounts of free queuine and Q‐deficient tRNAs.
Langgut, W., Kersten, H.
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Hexachlorobenzene-Induced Early Changes in Ornithine Decarboxylase and Protein Tyrosine Kinase Activities, Polyamines and c-Myc, c-Fos and c-Jun Proto-Oncogenes in Rat Liver [PDF]
Toxicological Sciences, 2003 El hexaclorobenceno (HCB) es un compuesto químico lipófilo que se distribuye ampliamente en el medio ambiente. Se sabe que el HCB causa tumores hepáticos en animales de experimentación. En el presente estudio se investigó el efecto in vivo del tratamiento con HCB sobre las actividades de la ornitina descarboxilasa (ODC) y la proteína tirosina quinasa ...
Andrea S, Randi +5 more
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Activation of endogenous c-fos proto-oncogene expression by human T-cell leukemia virus type I-encoded p40tax protein in the human T-cell line, Jurkat [PDF]
Journal of Virology, 1989 We examined the ability of the trans-acting factor p40tax of human T-cell leukemia virus type I (HTLV-I), which is thought to be a crucial molecule in T-cell transformation by HTLV-I, to activate expression of a set of endogenous cellular genes related to T-cell proliferation.
K, Nagata +3 more
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Proto-oncogene c-jun expression is induced by AML1-ETO in a JNK dependent manner:possible role in the pathogenesis of acute myeloid leukemia [PDF]
, 2003 Overexpression of proto-oncogene c-jun and constitutive activation of the Jun NH2-terminal kinase (JNK) signaling pathway have been implicated in the leukemic transformation process.
Elsaesser, Annika
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Bone morphogenetic proteins (BMP‐2 and BMP‐3) induce the late phase expression of the proto‐oncogene c‐fos in murine osteoblastic MC3T3‐E1 cells [PDF]
FEBS Letters, 1992 Here we report that bone morphogenetic proteins 2 and 3 (BMP‐2 and BMP‐3) induced marked expression of c‐fos mRNA in a biphasic manner, i.e. the late phase (48 to 60 h) as well as the immediate‐early phase (0.5 h), in murine osteoblastic MC3T3‐El cells in vitro.
Ohta, Shuichi +12 more
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C/EBPalpha downregualtes c-jun expression [PDF]
, 2003 The transcription factor C/EBPa is crucial for the differentiation of granulocytes. Conditional expression of C/EBPa triggers neutrophilic differentiation and C/EBPa can block TPA induced monocytic differentiation of bipotential myeloid cells.
Rangatia, Janki
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Epidermal Growth Factor Stimulation of Stromelysin mRNA in Rat Fibroblasts Requires Induction of Proto-Oncogenes c-fos and c-jun and Activation of Protein Kinase C [PDF]
Molecular and Cellular Biology, 1990 Stromelysin (transin) is a secreted metalloprotease that is transcriptionally induced by a variety of growth factors and oncogenes. We examined the necessity of specific secondary (protein kinase C) and tertiary (c-fos and c-jun protein products) messengers in the transactivation of stromelysin gene expression by epidermal growth factor (EGF).
S E, McDonnell +2 more
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The role of the proto-oncogene Ski in cortical development [PDF]
, 2013 The proto-oncogene Ski is an evolutionary conserved protein associated with various cellular processes such as proliferation and differentiation as well as transformation and tumor progression.
Baranek, Constanze Katharina Charlotte
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Signaling through CD44 affects cell cycle progression and c-Jun expression in acute myeloid leukemia cells [PDF]
, 2004 We present here the first evidence linking CD44 signaling to c-Jun expression and cell cycle progression in myeloid cell line models. CD44 ligation with the anti-CD44 monoclonal antibodies have been shown to induce differentiation and inhibit the ...
Peer Zada, Abdul Ali
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Role of protein kinase C and cyclic adenosine monophosphate in the regulation of tissue-type plasminogen activator, plasminogen activator inhibitor-1, and platelet-derived growth factor mRNA levels in human endothelial cells. Possible involvement of proto-oncogenes c-jun and c-fos. [PDF]
Arteriosclerosis and Thrombosis: A Journal of Vascular Biology, 1991 Activation of protein kinase C leads to a strong induction of tissue-type plasminogen activator (t-PA) expression in endothelial cells. Using endothelial cells from human umbilical vein (HUVECs) and human aorta (HAECs), we have studied this regulation of t-PA and its inhibitor, plasminogen activator inhibitor-1 (PAI-1), at the mRNA level and have ...
Kooistra, T. +7 more
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