The olive biophenols oleuropein and hydroxytyrosol selectively reduce proliferation, influence the cell cycle, and induce apoptosis in pancreatic cancer cells [PDF]
, 2018 Current chemotherapy drugs for pancreatic cancer only offer an increase in survival of up to six months. Additionally, they are highly toxic to normal tissues, drastically affecting the quality of life of patients. Therefore, the search for novel agents,
Bond, Danielle R. +6 more
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Functions of p120ctn in development and disease [PDF]
, 2012 p120 catenin (p120ctn), a component of the cadherin-catenin complex, was the first member to be identified in a most interesting subfamily of the Armadillo family. Several p120ctn isoforms are generated by alternative splicing.
Pieters, Tim +2 more
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Spaceflight modulates gene expression in the whole blood of astronauts [PDF]
, 2016 Astronauts are exposed to a unique combination of stressors during spaceflight, which leads to alterations in their physiology and potentially increases their susceptibility to disease, including infectious diseases.
Barrila, Jennifer +7 more
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Epidermal Growth Factor Stimulation of Stromelysin mRNA in Rat Fibroblasts Requires Induction of Proto-Oncogenes c-fos and c-jun and Activation of Protein Kinase C [PDF]
Molecular and Cellular Biology, 1990 Stromelysin (transin) is a secreted metalloprotease that is transcriptionally induced by a variety of growth factors and oncogenes. We examined the necessity of specific secondary (protein kinase C) and tertiary (c-fos and c-jun protein products) messengers in the transactivation of stromelysin gene expression by epidermal growth factor (EGF).
S E, McDonnell +2 more
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Functions of p120ctn isoforms in cell-cell adhesion and intracellular signaling [PDF]
, 2012 The functions of many organs depend on the generation of an epithelium. The transition from a set of loosely connected nonpolarized cells to organized sheets of closely associated polarized epithelial cells requires the assembly of specialized cell ...
Pieters, Tim +2 more
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Role of protein kinase C and cyclic adenosine monophosphate in the regulation of tissue-type plasminogen activator, plasminogen activator inhibitor-1, and platelet-derived growth factor mRNA levels in human endothelial cells. Possible involvement of proto-oncogenes c-jun and c-fos. [PDF]
Arteriosclerosis and Thrombosis: A Journal of Vascular Biology, 1991 Activation of protein kinase C leads to a strong induction of tissue-type plasminogen activator (t-PA) expression in endothelial cells. Using endothelial cells from human umbilical vein (HUVECs) and human aorta (HAECs), we have studied this regulation of t-PA and its inhibitor, plasminogen activator inhibitor-1 (PAI-1), at the mRNA level and have ...
Kooistra, T. +7 more
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The transcription factor ATF5: role in cellular differentiation, stress responses, and cancer. [PDF]
, 2017 Activating transcription factor 5 (ATF5) is a cellular prosurvival transcription factor within the basic leucine zipper (bZip) family that is involved in cellular differentiation and promotes cellular adaptation to stress.
Angelastro, James M, Sears, Thomas K
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Chinese Journal of Lung Cancer, 2010 Background and objective Cyclooxygenases (COX), the key enzymes in the conversion of arachidonic acid (AA) to prostaglandins (PGs), are involved in initiation and progression of cancer.
Xiaohong ZHAO +3 more
doaj +1 more source
A biologia molecular no prognóstico do carcinoma da tireóide
Revista do Colégio Brasileiro de CirurgiõesThis overview examines some selected genetic mechanisms of cancer development. Strong evidence has been accumulated suggesting that alteration in either the struture or activity of proto-oncogene contributes to the development and for the maintenance of ...
Aluizio Soares de Souza Rodrigues
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Genome-wide discovery of modulators of transcriptional interactions in human B lymphocytes
, 2006 Transcriptional interactions in a cell are modulated by a variety of mechanisms that prevent their representation as pure pairwise interactions between a transcription factor and its target(s). These include, among others, transcription factor activation
Banerjee, Nilanjana +4 more
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