Drosophila as a model system to study nonautonomous mechanisms affecting tumour growth and cell death [PDF]
, 2018 The study of cancer has represented a central focus in medical research for over a century. The great complexity and constant evolution of the pathology require the use of multiple research model systems and interdisciplinary approaches.
Cordero, Julia B. +2 more
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ETS1 is a genome-wide effector of RAS/ERK signaling in epithelial cells [PDF]
, 2014 The RAS/ERK pathway is commonly activated in carcinomas and promotes oncogenesis by altering transcriptional programs. However, the array of cis-regulatory elements and trans-acting factors that mediate these transcriptional changes is still unclear. Our
Budka, Justin A. +3 more
core +1 more source
Morphogenesis of the vulva and the vulval-uterine connection [PDF]
, 2012 The C. elegans hermaphrodite vulva is an established model system to study mechanisms of cell fate specification and tissue morphogenesis. The adult vulva is a tubular shaped organ composed of seven concentric toroids that arise from selective fusion ...
Gupta, Bhagwati P. +2 more
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Genome-wide discovery of modulators of transcriptional interactions in human B lymphocytes
, 2006 Transcriptional interactions in a cell are modulated by a variety of mechanisms that prevent their representation as pure pairwise interactions between a transcription factor and its target(s). These include, among others, transcription factor activation
Banerjee, Nilanjana +4 more
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The Journal of biological chemistry, 1999 Extracellular nucleotides acting through specific P2 receptors activate intracellular signaling cascades. Consistent with the expression of G protein-coupled P2Y receptors in skeletal tissue, the human osteosarcoma cell line SaOS-2 and primary osteoblasts express P2Y1 and P2Y2 receptors, respectively.
W B, Bowler +7 more
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Pattern of expression of the jun family of transcription factors during the early development of the inner ear: implications in apoptosis [PDF]
, 1999 8 pages, 6 figures, 1 table.Jun transcription factors have been implicated in the regulation of cell proliferation, differentiation and apoptosis. We have investigated the relationship between Jun expression and cell death in the developing chicken inner
Cañón, Susana +5 more
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Angiotensin II induces hypertrophy of human airway smooth muscle cells: expression of transcription factors and transforming growth factor-beta1 [PDF]
, 1998 Increased smooth muscle mass due to hyperplasia and hypertrophy of airway smooth muscle (ASM) cells is a common feature in asthma. Angiotensin II (Ang II), a potent vasoconstrictor and mitogen for a wide variety of cells,
Jongste, J.C. (Johan) de +3 more
core
In vivo monitoring of a cAMP-stimulated DNA-binding activity [PDF]
, 1990 Boshart, Michael +4 more
core +1 more source
Tumor invasion and metastasis involves complex remodeling of gene expression programs governing epithelial homeostasis. Mutational activation of the RAS-ERK is a frequent occurrence in many cancers and has been shown to drive overexpression of the AP-1 ...
Amalia, Marcia +14 more
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Study on the correlation between Interleukin 4 and febrile seizures. [PDF]
CytojournalXiang X +7 more
europepmc +1 more source