Results 51 to 60 of about 35,717 (218)

The effect of oxidation on the stability of G-quadruplex DNA : implications for oncogene expression [PDF]

, 2011
G-quadruplexes (G4-DNA) are a class of secondary structures formed from Guanine rich sequences. In recent years these structures have been implicated in both telomere maintenance and oncogene expression, and have been shown to be abundant in upstream ...
Stebbeds, William Joshua David
core  

Integrative Single‐Cell RNA Sequencing and Spatial Transcriptomics Uncover Distinct Fibroblast–Macrophage Crosstalk in Human Hip Synovium Between Patients With Femoroacetabular Impingement and Osteoarthritis

Arthritis &Rheumatology, Volume 78, Issue 6, Page 1219-1230, June 2026.
Objective Femoroacetabular impingement (FAI) and synovitis have been recognized as essential factors for developing osteoarthritis (OA) in the hip joints. However, little is known about altered synovial cellular compositions, their associated transcriptomic profiles, and cell–cell interactions in FAI and hip OA.
Gulzada Kulzhanova, Alexis Klee, Mina Botros, Victoria L. Hansen, John Reuter, Eliya Tazreena Tashbib, Eloise Fadial, Benjamin F. Ricciardi, Brian Giordano, Chia‐Lung Wu   +9 more
wiley   +1 more source

c-Fos proto-oncoprotein is degraded by the proteasome independently of its own ubiquitinylation in vivo

, 2003
Prior ubiquitinylation of the unstable c-Fos proto-oncoprotein is thought to be required for recognition and degradation by the proteasome.
Ferrara, P., Acquaviva, C., P. Ferrara, M. Piechaczyk, Bossis, G., Piechaczyk, M., I. Jariel-Encontre, G. Bossis, C. Acquaviva, Jariel-Encontre, I., Piechaczyk, Marc   +10 more
core   +1 more source

C-terminal binding proteins: Emerging roles in cell survival and tumorigenesis [PDF]

, 2006
Within a cell, the levels and activity of multiple pro- and anti-apoptotic molecules act in concert to regulate commitment to apoptosis. Whilst the balance between survival and death can be tipped by the effects of single molecules, cellular apoptosis ...
Blaydes, J.P., J. P. Blaydes, Bergman, L.M., L. M. Bergman   +3 more
core   +1 more source

Synergistic Antitumor Activity of HAT Inhibitor A485 and XPO1 Inhibitor KPT8602 in Multiple Myeloma

Cancer Medicine, Volume 15, Issue 6, June 2026.
ABSTRACT Background Multiple myeloma (MM) remains the second most common hematologic malignancy, necessitating the identification of novel therapeutic targets. MM is characterized by a distinct epigenetic landscape driven by aberrant chromatin activation and super‐enhancer addiction.
Hong Xu, Wenqi Wu, Yanan Jiang, Jinhuan Wang, Yixin Zhai, Zhigang Zhao   +5 more
wiley   +1 more source

Heterodimerization with different Jun proteins controls c-Fos intranuclear dynamics and distribution.

, 2010
International audienceThe c-Fos proto-oncogenic transcription factor defines a multigene family controlling many processes both at the cell and the whole organism level.
Malnou, C. E., Moquet-Torcy, G., Moquet-Torcy, Gabriel, Piechaczyk, Marc, Cécile E. Malnou, Isabelle Jariel-Encontre, Cyril Favard, Jariel-Encontre, Isabelle, Brockly, Frederique, Favard, Cyril, Frédérique Brockly, Malnou, Cécile, Gabriel Moquet-Torcy, Marc Piechaczyk, Piechaczyk, M., Jariel-Encontre, I., Brockly, F., Favard, C.   +17 more
core   +1 more source

Polygonati Rhizoma Attenuates Oxidative Stress‐Induced Senescence in Periodontal Ligament Stem Cells

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
Network pharmacology identified the potential targets and pathways of Polygonati Rhizoma (PR) against aging‐related periodontitis through PPI, GO/KEGG enrichment, and molecular docking. Experimental validation in a D‐galactose‐induced senescence model of periodontal ligament stem cells showed that PR‐medicated serum attenuated cellular senescence and ...
Xinran Feng, Ying An, Fanfan Hou, Qian Guo, Shanshan Cai, Hongbin Xu, Youfu He   +6 more
wiley   +1 more source

Complex mechanisms for c-fos and c-jun degradation

, 1997
c-fos and c-jun proto-oncogenes have originally been found in mutated forms in murine and avian oncogenic retroviruses. They both define multigenic families of transcription factors. Both c-jun and c-fos proteins are metabolically unstable.
Acquaviva, C., Pariat, M., Salvat, C., Furstoss, O., Steff, A. M., Piechaczyk, M., Jariel-Encontre, I., Piechaczyk, Marc   +7 more
core   +1 more source

ErbB2 signaling in breast cancer : the role of ErbB, Akt and ShcA phosphorylation [PDF]

, 2004
Breast cancer is the most common malignancy in women and is estimated to account for more than 200,000 new cancer cases in the United States in the year 2002. It now represents the second leading cause of death (40,000) from cancer in women.
Cicenas, Jonas
core   +1 more source

The granulocytic inducer C/EBPalpha inactivates the myeloid master regulator PU.1 [PDF]

, 2003
Verschiedene Transkriptionsfaktoren spielen eine Rolle in der Entwicklung myeloischer Zellen. PU.1, ein Transkriptionsfaktor aus der ETS-Familie, ist sowohl für die Entwicklung lymphatischer als auch für die Entwicklung myeloischer Zellen von Bedeutung ...
Reddy, Venkateshwar
core