Results 71 to 80 of about 35,717 (218)

JNK and ERK8 as downstream effectors of receptor tyrosine kinases

, 2006
MAP kinases are a super-family of serine-threonine protein kinases expressed in all eukaryotic cells. In mammals, there are many MAP kinases with different biological functions, grouped in distinctly regulated groups, ERK1/2 (extracellular signal related
Iavarone, Carlo
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Distribution and expression of mRNAs for the proto-oncogenes c-fos and c-jun in bone cells in vivo [PDF]

, 1998
In this study we assessed the expression and localization of the proto-oncogenes c-fos and c-jun in normal bone so as to gain more insight into the role of these proto-oncogenes in bone tissue.
Yoshida, M., Sugawara, S., Oyama, M., Igarashi, N., Ishigami, M., Kobayashi, M., Chiba, J., Kato, Y.   +7 more
core  

The role of oncogenic Cbl mutants in Kit signaling and myeloid transformation

, 2010
Acute myeloid leukemia (AML) is a hematopoietic cell disorder characterized by a block in differentiation and increased proliferation and survival of malignant blasts. Expansion of the malignant cell clone effects the normal production of blood cells and
Bandi, Srinivasa Rao
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Signaling in human osteoblasts by extracellular nucleotides. Their weak induction of the c-fos proto-oncogene via Ca2+ mobilization is strongly potentiated by a parathyroid hormone/cAMP-dependent protein kinase pathway independently of mitogen-activated protein kinase.

The Journal of biological chemistry, 1999
Extracellular nucleotides acting through specific P2 receptors activate intracellular signaling cascades. Consistent with the expression of G protein-coupled P2Y receptors in skeletal tissue, the human osteosarcoma cell line SaOS-2 and primary osteoblasts express P2Y1 and P2Y2 receptors, respectively.
W B, Bowler, C J, Dixon, C, Halleux, R, Maier, G, Bilbe, W D, Fraser, J A, Gallagher, R A, Hipskind   +7 more
openaire   +1 more source

Cellular and viral Fos proteins are degraded by different proteolytic systems

, 2001
c-Fos proto-oncoprotein is a short-lived transcription factor degraded by the proteasome in vivo. Its mutated forms expressed by the mouse osteosarcomatogenic retroviruses, FBJ-MSV and FBR-MSV, are stabilized two- and threefold, respectively.
Acquaviva, C., Ferrara, P., Salvat, C., Bossis, G., Piechaczyk, M., Jariel-Encontre, I., Brockly, F., Piechaczyk, Marc   +7 more
core   +1 more source

Role of the c-fos gene expression on the mitogenic response in EL2 rat fibroblasts

, 1988
Stimulation of the growth of quiescent fibroblasts by polypeptide growth factors is accompanied by the rapid induction of the c-fos proto-oncogene. To investigate whether there exists a relationship between mitogenic activity and c-fos expression, we ...
P. Di Francesco, LIBOI, Elio Maria
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Structure, chromosome location, and expression of the mouse zinc finger gene Krox-20: multiple gene products and coregulation with the proto-oncogene c-fos

Molecular and Cellular Biology, 1989
Philippe Chavrier, U. Janssen‐Timmen, Marie-Geneviève Mattei, M. Zerial, R. Bravo, P. Charnay   +5 more
semanticscholar   +1 more source

Expressão e localização das proteínas c-Fos e receptor de estrogênio beta no testículo humano [PDF]

, 2006
The testes are glands with endocrine and exocrine functions, the latter being characterized by sperm formation, or spermatogenesis. This is under the control of a complex system involving endocrine and paracrine signalization.
Fabiano Conde Araujo
core   +1 more source

The ability of Fos family members to produce phenotypic changes in epithelioid cells is not directly linked to their transactivation potentials.

, 2002
Numerous studies have revealed distinct functions of Fos proteins in different mouse tissues and cell lines. Here, we perform a direct comparison of the features of exogenous c-Fos, Fra-1 and Fra-2 proteins expressed in murine tumor cells of epithelial ...
Grigorian, Mariam,, Tulchinsky, Eugene,, Tkach, Vadim,, Berezin, Vladimir,, Berezin, V, Andersen, H, Grigorian, M, Mahmood, Shaukat,, Mahmood, S, Cohn, M, Andersen, Henriette,, Kustikova, O, Kustikova, Olga,, Lukanidin, E, Lukanidin, Eugene,, Tkach, V, Bock, E, Tulchinsky, E, Bock, Elisabeth,, Cohn, Martin,   +19 more
core   +1 more source

Interferon-γ induces the expression of immediate early genes c-fos and c-jun in astrocytes

, 2013
The expression of the proto-oncogenes, c-fos and c-jun, in cultured mouse astrocytes and its induction by the potent astrocyte activator interferon-γ (IFN-γ), were examined by Northern blot and flow cytometry.
Rubio, Nazario
core