Results 191 to 200 of about 211,026 (232)
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Proto-Oncogenes And Cardiac Hypertrophy

Annual Review of Physiology, 1989
Generalized or focal myocardial hypenrophy is a component of most types of cardiac disease. Abnormalities of this growth process, which include in­ adequate, idiopathic, and pathological hypertrophy, have great clinical sig­ nificance. Postnatal heart enlargement is produced largely by increased size of striated muscle cells (hypertrophy) and increased
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The RET proto‐oncogene and cancer

Journal of Internal Medicine, 1995
Abstract. The RET proto‐oncogene, a receptor tyrosine kinase, has been evaluated as a candidate gene for multiple endocrine neoplasia type 2A and type 2B (MEN 2A and MEN 2B), for familial medullary thyroid carcinoma (FMTC), and for sporadic cases of medullary thyroid carcinoma (MTC) and pheochromocytomas. We determined the genomic structure of RET and
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Proto-oncogenes and differentiation

Trends in Biochemical Sciences, 1986
Abstract Since their discovery, the cellular homologues of retroviral oncogenes have been presumed to play a role in growth control, mainly because of their potential to induce uncontrolled cellular proliferation. This notion is now strongly supported by evidence that the products of several proto-oncogenes are either growth factors or growth factor ...
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Cellular Proto-oncogenes

1988
Retroviral oncogenes originally were derived from genes in eukaryotic cells. The seminal discovery that DNA sequences within normal, uninfected, nonmalignant cells were homologous to retroviral oncogenes was made in 1976. Cellular proto-oncogenes have exon and intron structures typical of eukaryotic genes.
Kathy B. Burck   +2 more
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Transcriptional autoregulation of the proto-oncogene fos [PDF]

open access: possibleNature, 1988
Serum-induced transcription of the proto-oncogene fos is under negative feedback regulation mediated by the fos protein. The fos promoter region responsive to repression is also required for serum inducibility and binds a nucleoprotein complex in which the nuclear factor AP-1 is associated with fos protein.
Inder M. Verma   +2 more
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Proto-Oncogenes and Human Cancers

New England Journal of Medicine, 1987
The idea that specific genes or groups of genes are responsible for the induction or maintenance of cancer is by no means new. Recent research efforts to understand such genetic sequences have focused on the study of cellular oncogenes or proto-oncogenes.
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The significance of proto-oncogenes in carcinogenesis

Medical Hypotheses, 1987
A survey of the literature on activated proto-oncogenes shows that they are involved in the development of cancer but apparently not in the initiation process. The review of Klein and Klein comes to conclusions in opposition to the review of Duesberg. I favor the latter here.
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Proto‐oncogenes in cell differentiation

BioEssays, 1990
AbstractProto‐oncogene products may be multi‐functional proteins with various roles in cell differentiation as well as cell proliferation. The molecular biology of the gene products of three well characterized proto‐oncogenes (c‐fos, c‐myc and c‐src) are described, and the roles of three other proto‐oncogene products, involved in hormone and growth ...
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Cyclin D1 as a cellular proto-oncogene

Seminars in Cancer Biology, 1995
Deregulated expression of cyclin D1 occurs in several types of human cancer. Since it often results from a specific chromosomal abnormality, this over-expression is likely to be significant in the development of the disease. Cyclin D1 is also implicated in virally induced tumors in mice and transgenic models based on ectopic expression if cyclin D1 ...
Gordon Peters, Stewart Bates
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Chromosomal translocations in lymphoid malignancies reveal novel proto-oncogenes.

Annual Review of Immunology, 1992
Chromosomal translocation within B and T cell malignancies has proven a rich source for proto-oncogenes. The obligate DNA breaks within immunoglobulin (Ig) and T cell receptor (TCR) loci are frequently the sites of recurrent translocations.
S. Korsmeyer
semanticscholar   +1 more source

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