Results 231 to 240 of about 226,605 (267)
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DNA and Cell Biology, 1992
Among environmental pollutants, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD; dioxin) is one of the most potent tumor promoters and teratogens known. The molecular mechanisms responsible for the biological activity of TCDD, however, remain largely unknown ...
Alvaro Puga, D. Nebert, France Carrier
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Among environmental pollutants, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD; dioxin) is one of the most potent tumor promoters and teratogens known. The molecular mechanisms responsible for the biological activity of TCDD, however, remain largely unknown ...
Alvaro Puga, D. Nebert, France Carrier
semanticscholar +1 more source
Proto-Oncogenes and Human Cancers
New England Journal of Medicine, 1987The idea that specific genes or groups of genes are responsible for the induction or maintenance of cancer is by no means new. Recent research efforts to understand such genetic sequences have focused on the study of cellular oncogenes or proto-oncogenes.
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The significance of proto-oncogenes in carcinogenesis
Medical Hypotheses, 1987A survey of the literature on activated proto-oncogenes shows that they are involved in the development of cancer but apparently not in the initiation process. The review of Klein and Klein comes to conclusions in opposition to the review of Duesberg. I favor the latter here.
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Proto‐oncogenes in cell differentiation
BioEssays, 1990AbstractProto‐oncogene products may be multi‐functional proteins with various roles in cell differentiation as well as cell proliferation. The molecular biology of the gene products of three well characterized proto‐oncogenes (c‐fos, c‐myc and c‐src) are described, and the roles of three other proto‐oncogene products, involved in hormone and growth ...
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Cyclin D1 as a cellular proto-oncogene
Seminars in Cancer Biology, 1995Deregulated expression of cyclin D1 occurs in several types of human cancer. Since it often results from a specific chromosomal abnormality, this over-expression is likely to be significant in the development of the disease. Cyclin D1 is also implicated in virally induced tumors in mice and transgenic models based on ectopic expression if cyclin D1 ...
Gordon Peters, Stewart Bates
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Regulation of the vav proto-oncogene by LKLF
Gene, 2001The transcriptional induction of the vav proto-oncogene coincides with the first appearance of the definitive hematopoietic stem cell in the aorta-gonad-mesonephros region. Vav promoter activity was dependent on a previously identified 23 bp DNA segment containing PU.1 and Runx1/AML-1 binding sites and on a newly identified, highly conserved, 12 bp DNA
Rodney S. Kawahara +2 more
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Expression of proto-oncogenes in neural tissues
Brain Research, 1988Several proto-oncogenes have been shown to be expressed in tissues of neural origin. In most cases, their expression is developmentally regulated and they encode proteins similar in their sequence to a variety of known proteins involved in transferring information from the cell surface to the nucleus. Some of the proto-oncogenes, including src and yes,
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Proto-oncogenes in Drosophila melanogaster
Trends in Genetics, 1987Abstract More than ten different proto-oncogenes have been identified in the genome of Drosophila melanogaster . Their structural characterizations shows a high degree of conservation compared with the corresponding genes in vertebrates, and provides interesting clues to the evolution of proto-oncogenes.
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Proto-oncogenes/ transcription factors
1998Following partial hepatectomy, there is a rapid and highly orchestrated series of biochemical events which occur prior to cellular proliferation. Some of these events are presumably intimately linked with the eventual regeneration of the liver, whereas others are likely to be stress-related or required for the continued differentiated function of the ...
J. K. Westwick, D. A. Brenner
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Proto-oncogenes in pattern formation
Trends in Genetics, 1987There is now a considerable body of evidence suggesting that protoonc~genes are cellular genes whose products play a fundamental role in the proliferation and differentiation of cells. Mutations in these genes convert them to active elements in the cooperative process of tumorigenesis. Specific functions have been assigned to certain proto-uncogenes on
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