Results 91 to 100 of about 4,711 (225)

Prebiotic Factors Influencing the Activity of a Ligase Ribozyme

Life, 2017
An RNA-lipid origin of life scenario provides a plausible route for compartmentalized replication of an informational polymer and subsequent division of the container.
Fabrizio Anella, Christophe Danelon
doaj   +1 more source

Design of Surface Modified Acyclovir-loaded Graphene Oxide–Mesoporous Silica Nanocomposite: Optimization and In Vitro Characterization

Nano Biomedicine and Engineering
Graphene oxide (GO) and mesoporous silica nanoparticle (MSN) have been documented as advanced nanocarriers for drug delivery due to their unique and versatile properties.
Ketan B. Patil, Jayvadan K. Patel, Hardik H. Goswami, Arjun S. Chaudhari   +3 more
doaj   +1 more source

Growth and Division in a Dynamic Protocell Model

Life, 2014
In this paper a new model of growing and dividing protocells is described, whose main features are (i) a lipid container that grows according to the composition of the molecular milieu (ii) a set of “genetic memory molecules” (GMMs) that undergo ...
Marco Villani, Alessandro Filisetti, Alex Graudenzi, Chiara Damiani, Timoteo Carletti, Roberto Serra   +5 more
doaj   +1 more source

Protocell arrays for simultaneous detection of diverse analytes

Nature Communications, 2021
Simultaneous detection of multiple analytes from a sample is currently difficult. Here the authors present protocell arrays in a customisable platform integrating cell-free expression with a polymer-based aqueous two-phase system; they use this for ...
Yan Zhang, Taisuke Kojima, Ge-Ah Kim, Monica P. McNerney, Shuichi Takayama, Mark P. Styczynski   +5 more
doaj   +1 more source

On RAF Sets and Autocatalytic Cycles in Random Reaction Networks

, 2014
The emergence of autocatalytic sets of molecules seems to have played an important role in the origin of life context. Although the possibility to reproduce this emergence in laboratory has received considerable attention, this is still far from being ...
A Filisetti, A Filisetti, A Filisetti, A-L Barabási, Alessandro Filisetti, B Alberts, D Segre, E Mossel, F Dyson, J Farmer, JW Szostak, L Schmidt, M Eigen, M Eigen, P Luisi, PF Stadler, R Diester, R Serra, Roberto Serra, RV Solé, S Jain, S Jain, S Rasmussen, SA Kauffman, SA Kauffman, SS Mansy, T Carletti, T Rocheleau, Tibor Gánti, W Hordijk, W Hordijk, Wim Hordijk   +31 more
core   +1 more source

Investigating Prebiotic Protocells for a Comprehensive Understanding of the Origins of Life: A Prebiotic Systems Chemistry Perspective

Life, 2019
Protocells are supramolecular systems commonly used for numerous applications, such as the formation of self-evolvable systems, in systems chemistry and synthetic biology.
Augustin Lopez, Michele Fiore
doaj   +1 more source

Membrane Fusion‐Inspired Nanomaterials: Emerging Strategies for Infectious Disease and Cancer Diagnostics

Advanced Healthcare Materials, Volume 15, Issue 6, 9 February 2026.
Membrane fusion‐inspired nanomaterials offer transformative potential in diagnostics by mimicking natural fusion processes to achieve highly sensitive and specific detection of disease biomarkers. This review highlights recent advancements in nanomaterial functionalization strategies, signal amplification systems, and stimuli‐responsive fusion designs,
Sojeong Lee, Khulan Nyamzaya, Jueun Han, Yejin Song, Jihee Lee, Jung Hyun Jo, Seungmin Bang, Eun‐Kyung Lim, Seungjoo Haam, Eunjung Kim   +9 more
wiley   +1 more source

Chemical systems, chemical contiguity and the emergence of life

Beilstein Journal of Organic Chemistry, 2017
Charting the emergence of living cells from inanimate matter remains an intensely challenging scientific problem. The complexity of the biochemical machinery of cells with its exquisite intricacies hints at cells being the product of a long evolutionary ...
Terrence P. Kee, Pierre-Alain Monnard
doaj   +1 more source

Co-loading of Levodopa and Curcumin Using Brain-targeted Protocells as a Drug Delivery System for Improving the Efficacy of Parkinson's Disease [PDF]

, 2020
Wenkai Zhou, Chang Liu, Feifei Yu, Xia Niu, Xiaomei Wang, Guiling Li, Xinru Li   +6 more
openalex   +1 more source

Membrane Semi‐Permeability and Ion Selectivity in Chemiosmosis: Open Systems Volume Dependence of Electrolyte Chemistry

Advanced Materials Interfaces, Volume 13, Issue 4, 17 February 2026.
Very small cellular compartments can break electroneutrality and harness proton gradients without active transport structures, whereas larger volumes cannot, underscoring why life's critical energy processes are confined in microscopic spaces. ABSTRACT The effect of pH changes in external ionic solutions on liposomes entrapping non‐permeable weak acid ...
Josep M. Ribó, Isabel Herreros, David Hochberg, Federico Morán, Michael Stich   +4 more
wiley   +1 more source