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Theoretical perspective on synthetic man‐made life: Learning from the origin of life
Quantitative Biology, 2023 Creating a man‐made life in the laboratory is one of life science’s most intriguing yet challenging problems. Advances in synthetic biology and related theories, particularly those related to the origin of life, have laid the groundwork for further ...
Lu Peng +11 more
doaj +1 more source
Microscopy techniques for protocell characterization
Polymer Testing, 2021 Recent advances have witnessed the research progress of synthetic preliminary forms of cell-like entities (protocells) towards understanding the origin of life.
Hua Wu, Yan Qiao
doaj +1 more source
Necessary and sufficient conditions for protocell growth [PDF]
, 2016 International audienceWe consider a generic protocell model consisting of any conservative chemical reaction network embedded within a membrane. The membrane results from the self-assembly of a membrane precursor and is semi-permeable to some nutrients ...
Bigan, Erwan +3 more
core +4 more sources
Myth and fact in the origins of cellular life on Earth [PDF]
, 2017 Research into the origins of the first protocell is of a multidisciplinary nature. It draws evidence from what we know about the Earth’s early atmosphere and environment, and about the most ancient features of the cell’s structure and composition.
Jowett, P. +2 more
core +1 more source
Interface‐Aware Design of Biocatalysis
Advanced Synthesis &Catalysis, Volume 368, Issue 7, 1 April 2026.Interfaces impact biocatalysis scalability. We reframe gas–liquid, liquid–liquid, and solid–liquid boundaries as design variables, specific interfacial area and renewal rate, that govern activation or deactivation. Mechanistic evidence, quantification tools, and reactor/material strategies enable longer lifetimes and higher integrated productivity by ...
Ariadna Pié Porta +4 more
wiley +1 more source
Prebiotic Factors Influencing the Activity of a Ligase Ribozyme
Life, 2017 An RNA-lipid origin of life scenario provides a plausible route for compartmentalized replication of an informational polymer and subsequent division of the container.
Fabrizio Anella, Christophe Danelon
doaj +1 more source
Multi-level selectional stalemate in a simple artificial chemistry [PDF]
, 2007 We describe a simple artificial chemistry which abstracts a small number of key features from the origin of life "replicator world" hypotheses. We report how this can already give rise to moderately complex and counter-intuitive evolutionary phenomena ...
B. McMullin +7 more
core +1 more source
Prebiotic Organic Chemistry of Diketopiperazines
Asian Journal of Organic Chemistry, Volume 15, Issue 4, April 2026.Diketopiperazines (DKPs) are considered essential in many life forms, but their prebiotic importance has not been fully understood. This review aims to discuss prebiotic organic chemistry for experimentally and computationally simulated reactions involving DKPs. ABSTRACT Even though the significance of amino acids and polypeptides is well recognized in
Jun Ohata
wiley +1 more source
Nano Biomedicine and EngineeringGraphene oxide (GO) and mesoporous silica nanoparticle (MSN) have been documented as advanced nanocarriers for drug delivery due to their unique and versatile properties.
Ketan B. Patil +3 more
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Growth and Division in a Dynamic Protocell Model
Life, 2014 In this paper a new model of growing and dividing protocells is described, whose main features are (i) a lipid container that grows according to the composition of the molecular milieu (ii) a set of “genetic memory molecules” (GMMs) that undergo ...
Marco Villani +5 more
doaj +1 more source