Results 91 to 100 of about 2,480 (202)

Fatty acid membrane assembly on coacervate microdroplets as a step towards a hybrid protocell model [PDF]

, 2014
Mechanisms of prebiotic compartmentalization are central to providing insights into how protocellular systems emerged on the early Earth. Protocell models are based predominantly on the membrane self-assembly of fatty-acid vesicles, although membrane ...
Williams, D. S., Stephen Mann, David Williams, T-Y. Dora Tang, D. S. Williams, Adam W. Perriman, Mann, Stephen, Tang, T-Y. Dora, Perriman, Adam W., Kuimova, Marina K., Thompson, Alexander J., Marina K. Kuimova, C. Rohaida Che Hak, Alexander J. Thompson, Che Hak, C R, Rohaida Che Hak, C., Dora Tang, T. Y.   +16 more
core   +1 more source

The Polymers of Life: Exploring Cellular Function Through Polymer Concepts

Advanced Science, Volume 13, Issue 33, 15 June 2026.
Biomolecular phase separation reveals that a hidden layer of cellular organization is governed by the principles of polymer science. This review bridges polymer physics and cell biology, offering a primer on fundamental concepts, proposing a framework for interrogating cellular function, and synthesizing biophysical methods for decoding macromolecular ...
Mark Chen, Ashutosh Chilkoti
wiley   +1 more source

Delivering Proteins and Enzymes to Solid Tumors Through the Development of Stimuli‐Responsive Nanocarriers

ChemNanoMat, Volume 12, Issue 6, June 2026.
Stimuli‐responsive strategies to achieve controlled release of protein‐based therapeutic agents into solid tumors. Proteins, enzymes, and peptides have long been recognized as valuable therapeutic agents, particularly in oncology. However, their complex chemical structures render them more sensitive than smaller chemotherapeutic drugs.
Guillermo Plaza‐Palomo, Diana Benita‐Donadios, Sandra Jiménez‐Falcao, Alejandro Baeza   +3 more
wiley   +1 more source

Non linear protocell models: Syncronisation and Chaos

, 2009
We consider generic protocells models allowing linear and non-linear kineticsfor the main involved chemical reactions.We are interested in understanding if and howthe protocell division and the metabolism do synchronize to give rise to ...
T. Carletti, VILLANI, Marco, SERRA, Roberto, I. Poli, FILISETTI, alessandro   +4 more
core  

Superstructural Ordering in Coacervate-based Protocell Networks [PDF]

Bottom-up assembly of higher-order cytomimetic systems capable of coordinated physical behaviours, collective chemical signalling and spatially integrated processing is a key challenge in the study of artificial multicellularity.
Lin, Yiyang, Mann, Stephen, Mu, Wenjing, Qiao, Yan, Wu, Jianzhong, Jia, Liyan, Zhou, Musen   +6 more
core   +1 more source

Reconciling Ligase Ribozyme Activity with Fatty Acid Vesicle Stability

Life, 2014
The “RNA world” and the “Lipid world” theories for the origin of cellular life are often considered incompatible due to the differences in the environmental conditions at which they can emerge.
Fabrizio Anella, Christophe Danelon
doaj   +1 more source

Nonequilibrium Spatiotemporal Sensing within Acoustically Patterned Two-Dimensional Protocell Arrays [PDF]

, 2018
Acoustically trapped periodic arrays of horseradish peroxidase (HRP)-loaded poly(diallydimethylammonium chloride) / adenosine 5'-triphosphate coacervate microdroplet-based protocells exhibit a spatiotemporal biochemical response when exposed to a ...
Stephen Mann, Li, Mei, Juntai Liu, Patil, Avinash J., Bruce W. Drinkwater (5962604), Drinkwater, Bruce W., Mei Li, Avinash J. Patil, Tian, Liangfei, Mann, Stephen, Stephen Mann (1700536), Liangfei Tian (2102173), Liangfei Tian, Liu, Juntai, Bruce W. Drinkwater, Mei Li (217363), Juntai Liu (5962601), Avinash J. Patil (1787875)   +17 more
core   +1 more source

Synergism and Mutualism in Non-Enzymatic RNA Polymerization

Life, 2014
The link between non-enzymatic RNA polymerization and RNA self-replication is a key step towards the “RNA world” and still far from being solved, despite extensive research.
Hussein Kaddour, Nita Sahai
doaj   +1 more source

Evolution and self-assembly of protocells [PDF]

The International Journal of Biochemistry & Cell Biology, 2009
Cells define the minimal building blocks of life. How cellular life emerged and evolved implies to cross the boundary between living and nonliving matter. Here we explore this problem by presenting several relevant components of the whole picture involving chemistry, physics and natural selection.
openaire   +2 more sources

Models of Protocells Undergoing Asymmetrical Division

Entropy
The conditions that allow for the sustained growth of a protocell population are investigated in the case of asymmetrical division. The results are compared to those of previous studies concerning models of symmetrical division, where synchronization ...
Marco Villani, Elena Alboresi, Roberto Serra   +2 more
doaj   +1 more source