Results 121 to 130 of about 7,267,888 (348)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Screening Lactic Acid Bacteria Strains for Their Tolerance to Increased Osmotic Pressure and Their Suitability to Ensile High Dry Matter Forages

Agriculture
Lactic acid bacteria (LAB) should not only survive, but also perform under increased osmotic pressure in the process of ensiling, which results from the best practice of wilting forage.
Siriwan D. Martens, Wolfgang Wagner, Mariana Schneider, Klaus Hünting, Susanne Ohl, Christof Löffler   +5 more
doaj   +1 more source

Session Initiation Protocol Attacks and Challenges

, 2012
In recent years, Session Initiation Protocol (SIP) has become widely used in current internet protocols. It is a text-based protocol much like Hyper Text Transport Protocol (HTTP) and Simple Mail Transport Protocol (SMTP).
Keshavarz, Hassan, Noor, Rafidah Md, Sattari, Mohammad Reza Jabbarpour   +2 more
core  

Presynchronization using a modified Ovsynch protocol or a single gonadotropin-releasing hormone injection 7 d before an Ovsynch-56 protocol for submission of lactating dairy cows to first timed artificial insemination [PDF]

, 2014
P.D. Carvalho, Jerry Guenther, M.J. Fuenzalida, M.C. Amundson, Milo C. Wiltbank, P.M. Fricke   +5 more
openalex   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Effectiveness of family metacognitive training in mothers with psychosis and their adolescent children: a multicenter study protocol

Frontiers in Psychology
BackgroundMore than half of women with psychosis take care of their children despite the difficulties caused by the disease. Additionally, these kids have a higher risk of developing a mental health disorder. However, no interventions have been developed
Susana Ochoa, Susana Ochoa, Susana Ochoa, Susana Ochoa, Victoria Espinosa, Victoria Espinosa, Victoria Espinosa, Raquel López-Carrilero, Raquel López-Carrilero, Raquel López-Carrilero, Irene Martinez, Alejandro De Haro Barrera, Irene Birulés, Irene Birulés, Ana Barajas, Trinidad Pélaez, Trinidad Pélaez, Luciana Díaz-Cutraro, Luciana Díaz-Cutraro, Luciana Díaz-Cutraro, Luciana Díaz-Cutraro, Marta Coromina, Alexandre González-Rodríguez, Marina Verdaguer-Rodríguez, Marina Verdaguer-Rodríguez, Marina Verdaguer-Rodríguez, Marina Verdaguer-Rodríguez, Alfonso Gutiérrez-Zotes, Alfonso Gutiérrez-Zotes, Carolina Palma-Sevillano, Carolina Palma-Sevillano, Cristian Montes, Judith Gallego, Beatriz Paya, Francesc Casanovas, Francesc Casanovas, María Roldán, Emma Noval, Paloma Varela Casals, Miriam Salas-Sender, Ana Aznar, Rosa Ayesa-Arriola, Rosa Ayesa-Arriola, Esther Pousa, Esther Pousa, Manuel Canal-Rivero, Nathalia Garrido-Torres, Clara Montserrat, Laura Muñoz-Lorenzo, Josep María Crosas   +49 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Mental health consequences for adolescents during the Russian invasion of Ukraine: protocol for the Ukraine Adolescent Mental Health Study

Frontiers in Child and Adolescent Psychiatry
BackgroundIn February 2022, Russia launched a full scale-invasion of Ukraine, which is the largest European ground offensive since the Second World War.
Olga Osokina, Sanju Silwal, Minja Westerlund, Emmi Heinonen, Susanna Hinkka-Yli-Salomäki, Gennadiy Putyatin, Yuliia Yaschchyshyna, Norbert Skokauskas, Matthew Hodes, Andre Sourander, Andre Sourander   +10 more
doaj   +1 more source

Approve protocol [PDF]

Lab Animal, 2012
Sylvia, Allen, Mary E, Martin
openaire   +2 more sources

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source