Results 171 to 180 of about 185,125 (388)

Effect of proton pump inhibitor alone or in combination with clarithromycin on mycobacterial growth in human alveolar macrophages [PDF]

open access: bronze, 2000
Katsuhiro Suzuki   +5 more
openalex   +1 more source

Leptin Aggravates Thoracic Aortic Dissection Through Impairment of Energy Metabolism in Nrip2+ Smooth Muscle Cells

open access: yesAdvanced Science, EarlyView.
Epidemiological data confirm obesity elevates thoracic aortic dissection (TAD) risk. Patient analyses implicate hyperleptinemia, where leptin binding to vascular smooth muscle cell (VSMC) receptors triggers Socs3‐mediated suppression of Stat5a transcriptional activity.
Ling Chen   +18 more
wiley   +1 more source

Targeted Dual‐Responsive Liposomes Co‐Deliver Jolkinolide B and Ce6 to Synergistically Enhance the Photodynamic/Immunotherapy Efficacy in Gastric Cancer through the PANoptosis Pathway

open access: yesAdvanced Science, EarlyView.
Schematic model of CJP–TiN liposomes for gastric cancer (GC) treatment. Internalizing RGD peptide (iRGD) targets tumor cells, while Chlorin e6 (Ce6) generates reactive oxygen species (ROS). Jolkinolide B (JB) activates the PANoptosis pathway via caspase‐8, enhancing GC cell death and immune response, transforming “cold tumors” into “hot tumors” by ...
Chenhui Ma   +14 more
wiley   +1 more source

A new mechanism for anti‐inflammatory actions of proton pump inhibitors – inhibitory effects on neutrophil–endothelial cell interactions [PDF]

open access: bronze, 2000
N. Yoshida   +6 more
openalex   +1 more source

A Human Engineered Heart Tissue‐Derived Lipotoxic Diabetic Cardiomyopathy Model Revealed Early Benefits of Empagliflozin

open access: yesAdvanced Science, EarlyView.
This study develops a human engineered heart tissue‐derived model of diabetic cardiomyopathy that accurately replicates the dynamic changes in the structural, contractile, and electrophysiological properties of the myocardium. Furthermore, this model is used to confirm the direct protective effects of empagliflozin on the heart through an SGLT2 off ...
Lin Cai   +9 more
wiley   +1 more source

Empiric treatment of children with gastroesophageal reflux-like symptoms: Effect of proton pump inhibitors

open access: yesThe Turkish Journal of Pediatrics, 2015
Gastroesophageal reflux disease is an important cause of morbidity in childhood. Although various diagnostic methods are available, short course of empiric treatment with a proton pump inhibitor is widely used in adults as a diagnostic test.
Mehmet Gündüz   +2 more
doaj  

Helicobacter pylori Detection Based on Synergistic Electromagnetic and Chemical Enhancement of Surface‐Enhanced Raman Scattering in 3D Hotspot‐Activated Gold Nanorods/Nano Mica Platelets/ZnO Quantum Dots

open access: yesAdvanced Science, EarlyView.
Gold nanorods hybridized with nano mica platelets and ZnO quantum dots are used for the rapid, sensitive, selective, and reproducible surface‐enhanced Raman scattering‐based detection of Helicobacter pylori in different scenarios. The origin of this high performance is ascribed to the synergy between the three operational enhancement mechanisms and the
Ming‐Chang Lu   +3 more
wiley   +1 more source

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