Results 201 to 210 of about 185,125 (388)

The Long Noncoding RNA ΒFaar Promotes White Adipose Tissue Browning and Prevents Diet‐Induced Obesity

open access: yesAdvanced Science, EarlyView.
βFaar selectively targets and inhibits the GTPase activity of the RAB18 protein, thereby reducing LD volume. Conversely, βFaar promotes nuclear translocation of the transcription factor IRF4 in inguinal white adipose tissue (iWAT), facilitating the browning of white adipose tissue and attenuating body fat accumulation.
Yue Yang   +13 more
wiley   +1 more source

Biohybrid Computing with Proteinoids and Algae

open access: yesAdvanced Science, EarlyView.
We developed a novel biohybrid computing system by combining proteinoid microspheres with algae. The biological mixture creates spontaneous electrical oscillations. These oscillations can perform simple logic operations, such as AND, OR, NAND, and NOR gates. Environmental factors like temperature and pH affect how the system works.
Panagiotis Mougkogiannis   +1 more
wiley   +1 more source

Machine Learning‐Augmented Molecular Dynamics Simulations (MD) Reveal Insights Into the Disconnect Between Affinity and Activation of ZTP Riboswitch Ligands

open access: yesAngewandte Chemie, EarlyView.
This study combines computational and experimental approaches to study how natural and synthetic small molecules interact with the ZTP riboswitch, a bacterial RNA element that regulates gene expression. Using chemical synthesis, biochemical approaches, and artificial intelligence augmented MD simulations, we analyze both ligand binding and riboswitch ...
Christopher R. Fullenkamp   +8 more
wiley   +2 more sources

Scalable and Integrated Photocatalytic Reactor Systems for Solar‐to‐Fuel Production: Photoredox and Photoreforming Processes

open access: yesAdvanced Energy Materials, EarlyView.
Solar fuels and other value‐added chemicals derived from light‐driven reactions are highly desirable. Although advanced photoactive materials have been reported, demonstrations of their feasibility in large‐scale production are needed. Hence, strategies and recent efforts in scaling up photocatalytic reactors and integrating them into comprehensive ...
Hoi Ying Chung   +5 more
wiley   +1 more source

Toward Complete CO2 Electroconversion: Status, Challenges, and Perspectives

open access: yesAdvanced Energy Materials, EarlyView.
Electrocatalytic CO2 reduction and CO2 batteries face challenges in achieving complete CO2 conversion with high conversion rates and Faradaic efficiency simultaneously. Existing systems compromise one for the other with incomplete CO2 conversion and inefficiencies, hindering practical applications. This perspective highlights state‐of‐the‐art progress,
Changfan Xu   +5 more
wiley   +1 more source

An Exploratory Analysis of Pharmaceutical Price Disparities and Their Implications Among Six Developed Nations [PDF]

open access: yes
In our study of 43 drugs, prescription drug prices in several wealthy nations (Australia, Canada, France, Germany, and the U.K.) were much lower than in the U.S. on average, well below relative per capita GDP. There was relatively little difference among
Calfee, John E.   +2 more
core   +1 more source

Proton pump inhibitors: better acid suppression when taken before a meal than without a meal

open access: bronze, 2000
Jan Gunnar Hatlebakk   +3 more
openalex   +1 more source

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