Results 41 to 50 of about 117,037 (362)

Proton Pump Inhibitors and CKD [PDF]

Journal of the American Society of Nephrology, 2016
Proton pump inhibitors (PPIs) are taken by millions of people around the world, often for many months or even years, and some take PPIs on a permanent basis. PPIs, which are available both by prescription and over the counter, generally have an excellent overall safety profile.
Mark A. Perazella, Dennis G. Moledina
openaire   +3 more sources

The relationship between long-term use of proton pump inhibitor (PPI) and hypomagnesemia in patients with gastroesophageal reflux disease

Caspian Journal of Internal Medicine, 2022
Background: The aim of this study was to evaluate the relationship between the long-term use of PPI and hypomagnesemia in patients with gastroesophageal reflux disease. Methods: This case control study was conducted on GERD patients with long-term use of
Abbas Arj, Zeinab Ghaletakizadeh, Hamidreza Gilassi, Mohsen Razavizadeh   +3 more
doaj  

Effects of stress ulcer prophylaxis in adult ICU patients receiving renal replacement therapy (Sup-Icu RENal, SIREN): Study protocol for a pre-planned observational study

Trials, 2018
Background Proton pump inhibitors are often used in critically ill patients to prevent gastrointestinal bleeding despite limited evidence for benefit.
Joerg C. Schefold, Anders Perner, Theis Lange, Jørn Wetterslev, Matt P. Wise, Mark Borthwick, Stepani Bendel, Frederik Keus, Anne Berit Guttormsen, Søren Marker, Mette Krag, Morten Hylander Møller, for the SUP-ICU investigators   +12 more
doaj   +1 more source

Pharmacology of proton pump inhibitors [PDF]

Current Gastroenterology Reports, 2008
The gastric H,K-ATPase is the primary target for the treatment of acid-related diseases. Proton pump inhibitors (PPIs) are weak bases composed of two moieties, a substituted pyridine with a primary pK(a) of about 4.0, which allows selective accumulation in the secretory canaliculus of the parietal cell, and a benzimidazole with a second pK(a) of about ...
Jai Moo Shin, George Sachs
openaire   +3 more sources

Clostridium difficile infection among veterans health administration patients [PDF]

, 2015
OBJECTIVETo report on the prevalence and incidence of Clostridium difficile infection (CDI) from 2009 to 2013 among Veterans Healthcare Administration patientsDESIGNA retrospective descriptive analysis of data extracted from a large electronic medical ...
Dubberke, Erik R, Gerding, Dale N, Kelly, Ciarán P, Kuntz, Jennifer L, Mahé, Cédric, Mills, Peter, Neily, Julia, Olsen, Margaret A, Young-Xu, Yinong   +8 more
core   +3 more sources

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

FEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan, Victoria Scarpelli, Marten Exterkate   +2 more
wiley   +1 more source

Laparoscopic fundoplication compared with medical management for gastro-oesophageal reflux disease : cost effectiveness study [PDF]

, 2009
Peer reviewedPublisher ...
Bojke, Laura, Campbell, Marion K, Epstein, David, REFLUX Trial Group, Sculpher, Mark J   +4 more
core   +2 more sources

Safety and effectiveness of Rivaroxaban, Dabigatran and Apixaban in patients with non-valvular atrial fibrillation for stroke prophylaxis

BMC Neurology
Background Atrial fibrillation is the most common arrhythmia that causes an increased risk of thromboembolism. We aimed to evaluate stroke and major bleeding risk in patients with atrial fibrillation using rivaroxaban, apixaban, dabigatran and the ...
Ceyda Tanoğlu, Alevtina Ersoy
doaj   +1 more source

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

FEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, Hubert Schrezenmeier, David Alexander Christian Messerer   +5 more
wiley   +1 more source