Results 61 to 70 of about 5,151 (179)

A Focus on Natural Autophagy Modulators as Potential Host‐Directed Weapons Against Emerging and Re‐Emerging Viruses

Medicinal Research Reviews, Volume 45, Issue 6, Page 1850-1882, November 2025.
ABSTRACT Autophagy is a highly conserved intracellular process involved in maintaining homeostasis and in the degradation of damaged organelles and external pathogens. Nature provides complex and varied reservoirs of scaffolds and chemical entities that may have a pivotal role in the search for new therapeutic leads.
Ilaria Cursaro, Sara Rossi, Stefania Butini, Sandra Gemma, Gabriele Carullo, Giuseppe Campiani   +5 more
wiley   +1 more source

New Mechanisms for Regulation of Intracellular Collagen Degradation in Fibrotic Lesions of Periodontal Tissues

The FASEB Journal, Volume 39, Issue 20, 31 October 2025.
Drug‐induced gingival overgrowth involves dysregulation of intracellular collagen degradation. The mechanisms that are involved in the regulation of lysosomal collagenolytic activity are poorly understood. Here, we focus on how cathepsins, Rabs, and V‐ATPases regulate intracellular collagen degradation and, in particular, the vesicular trafficking and ...
Wing Hei Wong, Ralph A. Zirngibl, Morris F. Manolson, Christopher A. McCulloch   +3 more
wiley   +1 more source

SENP6 Maintains Mitochondrial Homeostasis by Regulating Mitochondrial Protein Import Through deSUMOylation of TOM40

Advanced Science, Volume 12, Issue 40, October 27, 2025.
SUMOylation regulates mitochondrial processes, but its impact on protein import remains unclear. TOM40 is identified, a mitochondrial outer membrane channel protein, as a substrate of deSUMOylase SENP6. TOM40 SUMOylation disrupts outer membrane complex assembly, inhibits protein import, and compromises mitochondrial homeostasis.
Liubing Hu, Jianshuang Li, Haolin Guo, Lei Su, Peina Dong, Juan Huang, Yanyan Liu, Xinjie Liu, Zhenhuan Luo, Wei Xiong, Zhenyu Ju, Qinghua Zhou, Hao Wang, Wenjun Wang   +13 more
wiley   +1 more source

Transmembrane Topography of the 100-kDa a Subunit (Vph1p) of the Yeast Vacuolar Proton-translocating ATPase [PDF]

, 1999
Xing-Hong Leng, Tsuyoshi Nishi, Michael Forgac   +2 more
openalex   +1 more source

Resolution of Subunit Interactions and Cytoplasmic Subcomplexes of the Yeast Vacuolar Proton-translocating ATPase [PDF]

, 1996
John J. Tomashek, Justin L. Sonnenburg, John M. Artimovich, Daniel J. Klionsky   +3 more
openalex   +1 more source

Calumenin, A Calcium‐Binding Modulatory Protein, Effective in Pathological Calcifications and Cancers, With Therapeutic Application Promise

FASEB BioAdvances, Volume 7, Issue 10, October 2025.
Calumenin (CALU) is effective in calcium homeostasis, involved in various cellular processes, ER‐related functions, normal calcification processes, pathological calcium deposits, inflammatory diseases, and cancers. Additionally, it has been linked to cancer by controlling the γ‐carboxylation of vitamin K‐dependent proteins linked to cancer.
Parinaz Nasri Nasrabadi, Babak Jahangiri, Zahra Amiri, Forouzandeh Mahjoubi, Fatemeh Masoumi, Alireza Zomorodipour   +5 more
wiley   +1 more source

The Carba Mix—In Vitro Investigations of Potential Cocktail Effects in Patch Tests With Rubber Allergens

Contact Dermatitis, Volume 93, Issue 4, Page 316-327, October 2025.
The carba mix was studied in a human cell model to better understand human patch reactions to the mix. Our results support that the carba mix can give rise to cocktail effect and that patch testing with separate carba mix sensitisers may thus be more appropriate.
Linda Ljungberg Silic, Renato Ivan de Ávila, Sofía Carreira‐Santos, Gábor Merényi, Ola Bergendorff, Kathrin S. Zeller   +5 more
wiley   +1 more source

The Amino-terminal Domain of the Vacuolar Proton-translocating ATPase a Subunit Controls Targeting and in Vivo Dissociation, and the Carboxyl-terminal Domain Affects Coupling of Proton Transport and ATP Hydrolysis [PDF]

, 2001
Shoko Kawasaki-Nishi, Katherine Bowers, Tsuyoshi Nishi, Michael Forgac, Tom H. Stevens   +4 more
openalex   +1 more source

Proteomic changes during boron tolerance in barley(Hordeum vulgare) and the role of vacuolar proton-translocating ATPase subunit E [PDF]

, 2011
A. Emin Atik, G. Ozan Bozdag, Ersin AKINCI, Alaattin Kaya, Ahmet Koç, Talat Yalçın, Hüseyin Çağlar Karakaya   +6 more
openalex   +3 more sources

Canonical tyrosine‐based motifs are required for constitutive endocytosis and polarity of IRT1 and contribute to metal uptake

The Plant Journal, Volume 124, Issue 1, October 2025.
SUMMARY Endocytosis regulates the localization and abundance of plasma membrane proteins. Several endocytic mechanisms were shown to operate in plants. The plant metal transporter IRT1 was previously shown to undergo ubiquitin‐mediated endocytosis and degradation upon excess of some of its metal substrates.
Julien Spielmann, Nathalie Leonhardt, Julie Neveu, Grégory Vert   +3 more
wiley   +1 more source