Results 141 to 150 of about 848,265 (305)

Endosomal Escape of siRNA Polyplexes: A Molecular Dynamics Perspective on Underlying Mechanisms

Advanced Functional Materials, EarlyView.
Molecular dynamics simulations reveal distinct endosomal escape mechanisms of siRNA nanoparticles, ranging from electrostatic membrane attachment to hydrophobic membrane fusion. Hydrophobic residues and anionic endosomal lipids emerge as key determinants of membrane disruption, linking molecular interactions to experimental delivery performance and ...
Katharina M. Steinegger, Min Jiang, Florian Belger, Fabian Link, Benjamin Winkeljann, Olivia M. Merkel   +5 more
wiley   +1 more source

Temporal dynamics of lymphocytes in prostate cancer patients treated with proton therapy

Frontiers in Oncology
Radiotherapy can be both immunosuppressive and immunostimulatory. Radiation-induced lymphopenia (RIL) is an ongoing challenge in cancer treatment.
Sarah Salih Al-Hamami, Samuel Kurucz, Vladimír Vondráček, Vladimír Pekar, Michal Andrlík, Kateřina Dědečková, Iva Benešová, Alexandra Haas, Barbora Ondrová, Andrea Pasztorová, Pavel Vítek, Jiří Kubeš   +11 more
doaj   +1 more source

Programming Neuromorphic Plasticity Through Ionic and Electronic Coupling in Organic Electrochemical Transistors

Advanced Functional Materials, EarlyView.
Neuromorphic plasticity in OECTs is governed by the post‐stimulus evolution of coupled ionic and electronic states. Semiconductor chemistry and morphology, electrolyte composition and interfaces, and device architecture regulate ion injection, transport, confinement, and release, shifting responses from rapidly relaxing STP to metastable memory and ...
Inho Lee, Hyoik Jang, Ji Hwan Kim, Jonghyun Won, Namhee Kim, Wonseok Shin, Giwon Lee, Eunho Lee, Daegun Kim, Sungjun Park   +9 more
wiley   +1 more source

Microfluidic Architecting of Patchy MXene Core‐Shell Particles for Ultralow‐Loading Photothermal Shape‐Memory Actuation

Advanced Functional Materials, EarlyView.
Spatially distributing Ti3C2Tx nanosheets into core‐shell architecture, rather than as directly dispersed flakes, mitigates aggregation and enhances photon harvesting. When the Ti3C2Tx core‐shell particles are incorporated into a shape‐memory polymer matrix at an ultralow loading of 0.0024 wt%, the improved photothermal conversion translates into ...
May Maung Zaw, Maxim M. Trubyanov, Qian Wang, Siyu Chen, Hongyi Chen, Keyu Chen, Hongbin Sun, Muthu Vignesh Vellayappan, Xiaoying Qi, Sharon Mui Ling Nai, Kostya S. Novoselov, David W. Rosen, Daria V. Andreeva   +12 more
wiley   +1 more source

Selenium‐Integrated Cyanine Dye With Enhanced Photophysical Properties for Optoacoustic‐Guided Cancer Imaging and Therapy

Advanced Functional Materials, EarlyView.
This study introduces selenium‐integrated cyanine dye (Se‐Cyn), with superior photostability, absorption, and photothermal efficiency, outperforming ICG in NIR window. Its nanoparticle form remains stable in water, accumulates in tumors, and enables strong optoacoustic imaging and effective phototherapy outcomes.
Divyesh Shelar, Snehal Salunkhe, Tony Fröhlich, Uwe Klemm, Pia Anzenhofer, Birgit Rathkolb, Martin Hrabě de Angelis, Oliver Plettenburg, Michael Sattler, Sudesh T. Manjare, Vipul Gujrati, Vasilis Ntziachristos   +11 more
wiley   +1 more source

Respiratory-gated proton beam therapy for intrahepatic cholangiocarcinoma without fiducial markers

Radiation Oncology
Background Intrahepatic cholangiocarcinoma (ICC) is a challenging primary liver cancer with a poor prognosis, especially in unresectable cases. Traditional palliative irradiation is limited in reducing liver doses.
Akihito Okubo, Sae Matsumoto, Hiroyasu Tamamura, Yoshitaka Sato, Satoko Asahi, Hitoshi Tatebe, Kazutaka Yamamoto, Keiichiro Matsushita, Makoto Sasaki, Yoshikazu Maeda, Yuji Tameshige, Hajime Sunagozaka, Hiroyuki Aoyagi, Satoshi Shibata, Shigeyuki Takamatsu, Satoshi Kobayashi   +15 more
doaj   +1 more source

How the Porous Transport Layer Dictates Membrane Electrode Assembly Performance of IrO2 Catalysts

Advanced Functional Materials, EarlyView.
The Schottky barrier formed at the catalyst | PTL interface critically governs both the initial performance and long‐term durability of the PEMWE, and its magnitude is dictated by the catalyst's work function. This limitation can be resolved by combining a rutile IrO2 core for efficient electron transfer with an amorphous IrOx shell for high surface ...
Hyeseong Jeon, Seunghee Han, Jonghyeon Park, Sujin Park, Wonjae Lee, Jihan Kim, Hyunjoo Lee   +6 more
wiley   +1 more source

Correction: Feasibility of linac-based fractionated stereotactic radiotherapy and stereotactic radiosurgery for patients with up to ten brain metastases

Radiation Oncology, 2023
Masanori Hirata, Kazuaki Yasui, Naofumi Oota, Hirofumi Ogawa, Tsuyoshi Onoe, Sayo Maki, Yusuke Ito, Kenji Hayashi, Hirofumi Asakura, Shigeyuki Murayama, Koichi Mitsuya, Shoichi Deguchi, Katsumasa Nakamura, Nakamasa Hayashi, Tetsuo Nishimura, Hideyuki Harada   +15 more
doaj   +1 more source

Self‐Healing Hydrogel‐Enabled Modular Assembly of Bilayered Skin Construct for Hair Follicle Regeneration

Advanced Healthcare Materials, EarlyView.
Self‐healing assembly of two cell‐laden hydrogel layers creates a biomimetic skin construct that restores both dermal and epidermal functions, resulting in accelerated wound healing and enhanced hair follicle regeneration in a full‐thickness skin wound model. ABSTRACT Alopecia remains a pervasive clinical challenge, largely owing to the limited ability
JaeWook Park, Su Yong Kim, MinSu Jeong, Beom Joon Kim, Shin Hyuk Kang, Won‐Gun Koh   +5 more
wiley   +1 more source

Study of inelastic processes in proton-proton collisions at the LHC with the TOTEM experiment [PDF]

, 2011
The TOTEM experiment, located into the CMS cavern at the CERN Large Hadron Collider (LHC), is one of the six experiments that are investigating high energy physics at this new machine.
BROGI, PAOLO
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