Results 41 to 50 of about 422,862 (268)

Long-term results of a phase II study of hypofractionated proton therapy for prostate cancer: moderate versus extreme hypofractionation

Radiation Oncology, 2019
Background We performed a prospective phase II study to compare acute toxicity among five different hypofractionated schedules using proton therapy. This study was an exploratory analysis to investigate the secondary end-point of biochemical failure-free
Boram Ha, Kwan Ho Cho, Kang Hyun Lee, Jae Young Joung, Yeon-Joo Kim, Sung Uk Lee, Hyunjung Kim, Yang-Gun Suh, Sung Ho Moon, Young Kyung Lim, Jong Hwi Jeong, Haksoo Kim, Weon Seo Park, Sun Ho Kim   +13 more
doaj   +1 more source

Commissioning and quality assurance of a novel solution for respiratory-gated PBS proton therapy based on optical tracking of surface markers

Zeitschrift für Medizinische Physik, 2022
We present the commissioning and quality assurance of our clinical protocol for respiratory gating in pencil beam scanning proton therapy for cancer patients with moving targets.
Giovanni Fattori, Jan Hrbacek, Harald Regele, Christian Bula, Alexandre Mayor, Stefan Danuser, David C. Oxley, Urs Rechsteiner, Martin Grossmann, Riccardo Via, Till T. Böhlen, Alessandra Bolsi, Marc Walser, Michele Togno, Emma Colvill, Daniel Lempen, Damien C. Weber, Antony J. Lomax, Sairos Safai   +18 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

First-in-human trial using mixed-reality visualization for patient setup during breast or chest wall radiotherapy

Radiation Oncology
Background The purpose of this study is to assess the feasibility of mixed-reality (MixR) visualization for patient setup in breast and chest wall radiotherapy (RT) by performing a first-in-human clinical trial comparing MixR with a 3-point alignment ...
Perry B. Johnson, Julie Bradley, Samsun Lampotang, Amanda Jackson, David Lizdas, William Johnson, Eric Brooks, Raymond B. Mailhot Vega, Nancy Mendenhall   +8 more
doaj   +1 more source

Exploring new frontiers in the pulsed power laboratory: Recent progress

Results in Physics, 2015
One of the most fundamental processes in the Universe, nucleosynthesis of elements drives energy production in stars as well as the creation of all atoms heavier than hydrogen.
S. Adamenko, A. Esaulov, B. Ulmen, V. Novikov, S. Ponomarev, A. Adamenko, V. Artyuh, A. Gurin, V. Prokopenko, V. Kolomiyets, V. Belous, K.-J. Kim, G. Miley, A. Bassuney, D. Novikov   +14 more
doaj   +1 more source

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

FEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez, Mikael Oliveberg, Peter Brzezinski   +2 more
wiley   +1 more source

Gantry-based pencil beam scanning proton therapy for uveal melanoma: IMPT versus proton arc therapy

Radiation Oncology
Background This study reports the single-institution clinical experience of multifield pencil beam scanning (PBS) intensity-modulated proton therapy (IMPT) and dosimetric comparison to proton arc for uveal melanoma (UM) in a regular PBS gantry room ...
Hang Qi, Lei Hu, Sheng Huang, Yen-Po Lee, Francis Yu, Qing Chen, Yunjie Yang, Minglei Kang, Huifang Zhai, Milo Vermeulen, Andy Shim, Peter Park, Xuanfeng Ding, Jun Zhou, David H. Abramson, Jasmine H. Francis, Charles B. Simone, Christopher A. Barker, Haibo Lin   +18 more
doaj   +1 more source

Clinical results of proton beam therapy for elderly patients with non-small cell lung cancer

Radiation Oncology, 2018
Background The purpose of the present study was to evaluate retrospectively the efficacy and safety of proton beam therapy for elderly patients (≥80 years of age) with non-small cell lung cancer.
Takashi Ono, Tatsuya Nakamura, Hisashi Yamaguchi, Yusuke Azami, Kanako Takayama, Motohisa Suzuki, Hitoshi Wada, Yasuhiro Kikuchi, Masao Murakami, Kenji Nemoto   +9 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source