Results 61 to 70 of about 2,542,698 (234)

Mitigation of motion effects in pencil-beam scanning – Impact of repainting on 4D robustly optimized proton treatment plans for hepatocellular carcinoma

Zeitschrift für Medizinische Physik, 2022
Proton fields delivered by the active scanning technique can be interfered with the intrafractional motion. This in-silico study seeks to mitigate the dosimetric impacts of motion artifacts, especially its interplay with the time-modulated dose delivery.
Hilda Siregar, Christian Bäumer, Oliver Blanck, Mark Chan, Erik Engwall, Sandija Plaude, Bernhard Spaan, Beate Timmermann, Jörg Wulff   +8 more
doaj   +1 more source

Using Deep Learning for Fast Dose Refinement in Proton Therapy

, 2021
Proton therapy is nowadays a major clinical modality in the fight against cancer due to the advantages offered by its peculiar depth dose profile, that allows to improve its efficacy on tumors while reducing damages to healthy tissues.
Pasquale Caianiello, Lapenna, Fulvio, Muciaccia, Federico, Russo, Giorgio, Giuseppe Placidi, Giorgio Russo, Mignosi, Filippo, Matteo Spezialetti, Federico Muciaccia, Fracchiolla, Francesco, Placidi, Giuseppe, Filippo Mignosi, Francesco Fracchiolla, Fulvio Lapenna, Caianiello, Pasquale, Spezialetti, Matteo   +15 more
core   +1 more source

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Analytical probabilistic proton dose calculation and range uncertainties [PDF]

Journal of Physics: Conference Series, 2014
We introduce the concept of analytical probabilistic modeling (APM) to calculate the mean and the standard deviation of intensity-modulated proton dose distributions under the influence of range uncertainties in closed form. For APM, range uncertainties are modeled with a multivariate Normal distribution p(z) over the radiological depths z.
Bangert, M., Hennig, P., Oelfke, U.
openaire   +2 more sources

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

FEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer, Pawel Rubach, Zbigniew Dauter, Wojciech Dec, Dariusz Brzezinski, Marta Kulik, Wladek Minor, Mariusz Jaskolski   +7 more
wiley   +1 more source

Evaluation of magnetic resonance imaging derived synthetic computed tomography for proton therapy planning in prostate cancer

Physics and Imaging in Radiation Oncology
Background and purpose: Magnetic resonance imaging (MRI)-only workflow is used in photon radiotherapy (RT) today, but not yet for protons. To bring MRI-only proton RT into clinical use, proton dose calculation on MRI-derived synthetic CT (sCT) must be ...
Kajsa M.L. Fridström, René M. Winter, Natalie Hornik, Sigrun S. Almberg, Signe Danielsen, Kathrine R. Redalen   +5 more
doaj   +1 more source

Experimental assessment of proton dose calculation accuracy in small-field delivery using a mevion S250 proton therapy system

Journal of Medical Physics, 2018
Purpose: Dose calculation accuracy of the Varian Eclipse treatment planning system (TPS) is empirically assessed for small-aperture fields using a Mevion S250 double scattering proton therapy system.
Kyle D DePew, Salahuddin Ahmad, Hosang Jin   +2 more
doaj   +1 more source

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source