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Role of proton pumps in tumorigenesis
Biochemistry (Moscow), 2017One of the differences between normal and cancer cells is lower pH of the extracellular space in tumors. Low pH in the extracellular space activates proteases and stimulates tumor invasion and metastasis. Tumor cells display higher level of the HIF1α transcription factor that promotes cell switch from mitochondrial respiration to glycolysis.
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An Overview of Proton Pump Inhibitors
Gastroenterology Nursing, 2003Proton pump inhibitors are the standard of treatment for acid-related disorders. These disorders include gastroesophageal reflux disease and its complications (i.e., erosive esophagitis and Barrett's esophagus), peptic ulcer disease, Zollinger-Ellison syndrome, and idiopathic hypersecretion.
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Proton Pump Inhibitors and Mortality
Gastroenterology, 2023Helge L. Waldum, Reidar Fossmark
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Association of Proton Pump Inhibitor Use With All-Cause and Cause-Specific Mortality
Gastroenterology, 2022Chun-Han Lo, Raaj Mehta
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Vacuolar ATPases: Rotary Proton Pumps in Physiology and Pathophysiology
Nature Reviews Molecular Cell Biology, 2007Michael Forgac
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