Results 111 to 120 of about 260,677 (342)

MCHIT - Monte Carlo model for proton and heavy-ion therapy

, 2007
We study the propagation of nucleons and nuclei in tissue-like media within a Monte Carlo Model for Heavy-ion Therapy (MCHIT) based on the GEANT4 toolkit (version 8.2).
Greiner, Walter, Mishustin, Igor, Pshenichnov, Igor   +2 more
core   +1 more source

Next‐Generation Bio‐Reducible Lipids Enable Enhanced Vaccine Efficacy in Malaria and Primate Models

Advanced Functional Materials, EarlyView.
Structure–activity relationship (SAR) optimization of bio‐reducible ionizable lipids enables the development of highly effective lipid nanoparticle (LNP) mRNA vaccines. Lead LNPs show superior tolerability and antibody responses in rodents and primates, outperforming approved COVID‐19 vaccine lipids.
Ruben De Coen, Sabah Kasmi, Shrinivas Dumbre, Lies Baekens, Elise Seynaeve, Louise Van den Hauwe, Niccolò Cantini, Aello Garantoudi, Filipe Branco Madeira, Alain Marrot, Emma Tuypens, Sofie Seghers, Anna Kuchmiy, Elisabeth Brabants, Bart Vanderborght, Ine Maes, Sarah Vandenberghe, Jessica Filtjens, Alícia Gordún Peiró, Daliya Kancheva, Ayla Debraekeleer, Florence Lambolez, Emily De Lombaerde, Yong Chen, Rafael Miyazawa Martins, Pauline Formaglio, Damya Laoui, Sofie Deschoemaeker, Bruno G. De Geest, Rogerio Amino, Stefaan De Koker   +30 more
wiley   +1 more source

Smart Nanogels as Enzyme‐Driven Nanomotors for Navigating Viscous Physiological Barriers

Advanced Functional Materials, EarlyView.
Two families of urease‐powered nanomotors (NMs), with and without a p‐(2‐hydroxyethyl methacrylate) (p‐HEMA) shell, have been successfully prepared. Both types exhibit effective motion in highly viscous synovial fluid media at low urea concentrations (25 mM).
David Esporrín‐Ubieto, Noelia Ruiz‐González, Valerio Di Carlo, Daniel Sánchez‐deAlcázar, Florencia Lezcano, Anna Pushkareva Fazullina, Samuel Sánchez   +6 more
wiley   +1 more source

A proof-of-concept study of direct magnetic resonance imaging-based proton dose calculation for brain tumors via neural networks with Monte Carlo-comparable accuracy

Physics and Imaging in Radiation Oncology
Background and purpose: Proton therapy currently relies on computed tomography (CT) imaging despite magnetic resonance imaging’s (MRI) superior soft-tissue contrast.
Muheng Li, Carla Winterhalter, Xia Li, Sairos Safai, Antony Lomax, Ye Zhang   +5 more
doaj   +1 more source

Letter: Proton beam therapy for acromegaly. [PDF]

, 1975
T. D. R. Hockaday, A. H. Laing, R. B. Welbourn, M. Hartog   +3 more
openalex   +1 more source

DENTA: A Dual Enzymatic Nanoagent for Self‐Activating Tooth Whitening and Biofilm Disruption

Advanced Functional Materials, EarlyView.
The nanoapatite with dual enzymes (DENTA) accumulates in dentinal tubules, reducing hypersensitivity caused by dental nerve exposure and facilitating continuous ROS generation through salivary glucose for effective, long‐term whitening. The dentin structures remain non‐destructive due to the low concentration of ROS, demonstrating excellent cell ...
Junseok Kim, Dai‐Hwan Kim, Priyannth R. Sundharbaabu, Chae Yeon Lee, Jina Bae, Jiyu Hyun, Young‐Ju Jang, Haeni Kim, Min‐Ho Hong, Juewen Liu, Tobias Fey, Suk Ho Bhang, Jun Hyuk Heo, Jung Heon Lee   +13 more
wiley   +1 more source

Dosimetric and On-treatment Clinical Results of a Volumetric-based Skin-sparing Planning Technique for Patients Treated to the Breast and Chest Wall With Pencil-Beam Scanning Proton Therapy

Advances in Radiation Oncology
Purpose: This study evaluates the hypothesis that a volumetric skin-sparing planning technique (SSPT) will reduce acute dermatitis in patients treated to the breast or chest wall (CW) with proton pencil-beam scanning (PBS).
Avani D. Rao, MD, Alexander Goughenour, CS, CMD, Betelehem Kebede, BS, Caroline Bamberger, BS, Grayden MacLennan, MS, CMD, Jackeline Castro, BS, CMD, Lisa Stephenson, MS, CMD, Amanuel Negussie, MS, CMD, Sydney Seracino, CMD, Hongkun Wang, PhD, Stella Hetelekidis, MD, Sarah J. Gao, MD, Lonika Majithia, MS, MD, Ashish Chawla, MD, Ashkan Parniani, MBA, CMD, Peng Wang, PhD, DABR, Jiajin Fan, PhD, DABR   +16 more
doaj   +1 more source

Protons or megavoltage X-rays as boost therapy for patients irradiated for localized prostatic carcinoma an early phase I/II comparison [PDF]

, 1983
J. A. Duttenhaver, William U. Shipley, Theresa Perrone, Lynn Verhey, Michael Goitein, John E. Munzenrider, George R. Prout, Edward C. Parkhurst, Herman D. Suit   +8 more
openalex   +1 more source

Ionic Control of Microstructure and Lubrication in Charged, Physically Cross‐Linked Hydrogels

Advanced Functional Materials, EarlyView.
Here, charged, physically cross‐linked poly(methacrylamide‐co‐methacrylic acid) hydrogels stabilized by a short‐range attractive, long‐range repulsive potential is investigated. This work uncovers how salt addition alters not only swelling, but also the microstructure and dynamics, near‐surface stiffness and charge, and ultimately, its lubricity. Salts
Alexander Deptula, Rosa M. Espinosa‐Marzal   +1 more
wiley   +1 more source

Self‐Immolative Activatable Nanoassembly toward Immuno‐Photodynamic Therapy in TME

Advanced Functional Materials, EarlyView.
A quinone methide‐gated, self‐immolative, H2O2‐responsive nano‐photosensitizer (Pyz/PS) is developed for targeted immuno‐photodynamic therapy. Pyz/PS selectively activates within tumor microenvironments, restores photosensitizer activity, generates ROS, and depletes intracellular GSH, enhancing oxidative stress.
Jing Li, E Pang, Snehasish Debnath, Jia Hong, Aojun Qiu, Dongeun Kim, Goeun Kim, Minhuan Lan, Min‐Goo Lee, Qian‐Yong Cao, Jong Seung Kim   +10 more
wiley   +1 more source