Results 111 to 120 of about 5,053,091 (357)

Endocytic Programming via Porous Silicon Nanoparticles Enhances TLR4 Nanoagonist Potency for Macrophage‐Mediated Immunotherapy

Advanced Functional Materials, EarlyView.
Porous silicon nanoparticles (PSiNPs) reprogram macrophage endocytosis of manganese@albumin‐based TLR4 nanoagonists, driving TRIF‐biased TLR4 signaling, eliciting robust proinflammatory responses, and potentiating macrophage‐mediated immunotherapeutic effects against NSCLC.
Xiaomei Zhang, Huiying Li, Shuodan Huang, Linxuan Zhang, Yan Gao, Ruoran Wang, Xiaoyu Wang, Hélder A. Santos, Zhenyu Yin, Bing Xia   +9 more
wiley   +1 more source

The indication of palliative whole-brain radiotherapy for patients with brain metastases: a simple prognostic scoring system in the era of stereotactic radiosurgery

BMC Cancer
Background Stereotactic irradiation has become the mainstay treatment for brain metastases (BM), and whole-brain radiotherapy (WBRT) is often used for symptom palliation.
Toshiaki Hirose, Shoichi Deguchi, Kazuaki Yasui, Minoru Inoue, Tsuyoshi Onoe, Hirofumi Ogawa, Hirofumi Asakura, Koichi Mitsuya, Hideyuki Harada, Shigeyuki Murayama, Nakamasa Hayashi, Tetsuo Nishimura, Ryuta Saito   +12 more
doaj   +1 more source

Anionic Citrate‐Based 3D‐Printed Scaffolds for Tunable and Sustained Orthobiologic Delivery to Enhance Tissue Regeneration

Advanced Functional Materials, EarlyView.
A potent anionic citric acid‐based 3D‐printed scaffold is developed for the sustained and controlled release of orthobiologics to enhance orthopedic therapeutic efficacy. Comprehensive in vivo studies demonstrated effective bone fusion and high safety at a low dose of BMP‐2 delivered by the system, establishing it as a promising platform for safe ...
Se‐Hwan Lee, Ruqiang Lu, Andrew House, Zizhao Li, Lindsey Hammond Burton, Katie Josephine Sikes, Lynn Marie Pezzanite, Drew William Koch, Kevin Michael Labus, Ben Gadomski, Jeremiah Easley, Richard Tuan Tran, Su Chin Heo   +12 more
wiley   +1 more source

Proton therapy for non-small cell lung cancer: the road ahead.

Translational Lung Cancer Research, 2019
Proton therapy is an evolving radiotherapy modality with indication for numerous cancer types. With the benefits of reducing dose and sparing normal tissue, protons offer a clear physical and dosimetric advantage over photon radiotherapy for many ...
E. Brooks, M. Ning, V. Verma, X. Zhu, Joe Y. Chang   +4 more
semanticscholar   +1 more source

Chemo‐Mechanical Coupling in Hydrogels: Dynamics in the Diffusion‐Limited Regime

Advanced Functional Materials, EarlyView.
A time‐dependent continuum model is developed to capture the transient swelling dynamics of chemo‐mechanical hydrogels. By coupling chemical reactions, solvent transport, and polymer deformation, volume phase transitions, reaction kinetics, and transient mechanical instabilities are analyzed.
Yao Xiong, Aaveg Aggarwal, Monica Olvera de la Cruz   +2 more
wiley   +1 more source

Advances in proton therapy in lung cancer

Therapeutic Advances in Respiratory Disease, 2018
Lung cancer remains the leading cause of cancer deaths in the United States (US) and worldwide. Radiation therapy is a mainstay in the treatment of locally advanced non-small cell lung cancer (NSCLC) and serves as an excellent alternative for early stage
M. Vyfhuis, N. Onyeuku, T. Diwanji, S. Mossahebi, N. Amin, S. Badiyan, P. Mohindra, C. Simone   +7 more
semanticscholar   +1 more source

Functional Hydrogel for Modulating Lipid Droplets and Neuroinflammation in Head Injury

Advanced Functional Materials, EarlyView.
After TBI, elevated cholesterol levels in activated microglia lead to the accumulation of cholesterol esters in lipid droplets, exacerbating neuroinflammation. A β‐cyclodextrin‐conjugated GelMA (βCD‐GelMA) hydrogel is developed to promotes cholesterol efflux and reduces LDL influx, thereby alleviating intracellular cholesterol and lipid droplet buildup.
Feixiang Chen, Yvonne Shen, Yutong Shao, Tenghuan Ge, Haowen Qiao, Shangzhou Xia, Yafei Qu, Yuanpu Chiu, Ying Qin, Zhen Zhao   +9 more
wiley   +1 more source

A proof-of-concept study of direct magnetic resonance imaging-based proton dose calculation for brain tumors via neural networks with Monte Carlo-comparable accuracy

Physics and Imaging in Radiation Oncology
Background and purpose: Proton therapy currently relies on computed tomography (CT) imaging despite magnetic resonance imaging’s (MRI) superior soft-tissue contrast.
Muheng Li, Carla Winterhalter, Xia Li, Sairos Safai, Antony Lomax, Ye Zhang   +5 more
doaj   +1 more source

Selective Laser Sintering 3D Printing of Drug‐Loaded Intravitreal Implants

Advanced Functional Materials, EarlyView.
Selective laser sintering enables the fabrication of biodegradable and biocompatible intravitreal implants with tunable microstructures for sustained drug delivery. By modulating laser scanning speed, the polymer matrix architecture is engineered to control the release kinetics of dexamethasone and riboflavin over several months. This approach offers a
Iria Seoane‐Viaño, Carlos Bendicho‐Lavilla, Haya Alfassam, Bárbara Blanco‐Fernández, Abdul W. Basit, Francisco J. Otero‐Espinar   +5 more
wiley   +1 more source

Dosimetric and On-treatment Clinical Results of a Volumetric-based Skin-sparing Planning Technique for Patients Treated to the Breast and Chest Wall With Pencil-Beam Scanning Proton Therapy

Advances in Radiation Oncology
Purpose: This study evaluates the hypothesis that a volumetric skin-sparing planning technique (SSPT) will reduce acute dermatitis in patients treated to the breast or chest wall (CW) with proton pencil-beam scanning (PBS).
Avani D. Rao, MD, Alexander Goughenour, CS, CMD, Betelehem Kebede, BS, Caroline Bamberger, BS, Grayden MacLennan, MS, CMD, Jackeline Castro, BS, CMD, Lisa Stephenson, MS, CMD, Amanuel Negussie, MS, CMD, Sydney Seracino, CMD, Hongkun Wang, PhD, Stella Hetelekidis, MD, Sarah J. Gao, MD, Lonika Majithia, MS, MD, Ashish Chawla, MD, Ashkan Parniani, MBA, CMD, Peng Wang, PhD, DABR, Jiajin Fan, PhD, DABR   +16 more
doaj   +1 more source