Results 211 to 220 of about 45,570 (245)
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Unconventional actins and actin-binding proteins in human protozoan parasites
International Journal for Parasitology, 2015Actin and its regulatory proteins play a key role in several essential cellular processes such as cell movement, intracellular trafficking and cytokinesis in most eukaryotes. While these proteins are highly conserved in higher eukaryotes, a number of unicellular eukaryotic organisms contain divergent forms of these proteins which have highly unusual ...
Saravanamuthu Thiyagarajan
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Pore-forming proteins in pathogenic protozoan parasites
Trends in Microbiology, 1997Pore-forming proteins (PFPs) may play important roles in pathogenesis by protozoan parasites by either directly damaging the plasma membrane of the host cells or ensuring intracellular survival of the parasites by promoting their exit from lysosomal vacuoles.
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The role of ATP-binding cassette (ABC) proteins in protozoan parasites
Molecular and Biochemical Parasitology, 2009The ATP-binding cassette (ABC) superfamily is one of the largest protein families with representatives in all kingdoms of life. Members of this superfamily are involved in a wide variety of transport processes with substrates ranging from small ions to relatively large polypeptides and polysaccharides, but also in cellular processes such as DNA repair,
Dominique Aubert +2 more
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Isotopic labeling of recombinant proteins expressed in the protozoan host Leishmania tarentolae
Protein Expression and Purification, 2006Isotope labeling of recombinant proteins is a prerequisite for application of nuclear magnetic resonance spectroscopy (NMR) for the characterization of the three-dimensional structures and dynamics of proteins. Overexpression of isotopically labeled proteins in bacterial or yeast host organisms has several drawbacks. In this work, we tested whether the
Anca Niculae +2 more
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Protozoan protein tyrosine phosphatases
International Journal for Parasitology, 2008The aim of this review is to provide a synthesis of the published experimental data on protein tyrosine phosphatases from parasitic protozoa, in silico analysis based on the availability of completed genomes and to place available data for individual phosphatases from different unicellular parasites into the comparative and evolutionary context.
Alexandra V, Andreeva +1 more
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Isoprenylation of proteins in the protozoan Giardia lamblia
Molecular and Biochemical Parasitology, 1995We report the ability of Giardia lamblia to modify several of its cellular proteins by isoprenylation. Trophozoites cultured in the presence of [3H]mevalonate synthesized radiolabeled proteins of approx. 50 and 21-26 kDa. Chemical analysis indicated that farnesyl and geranylgeranyl isoprenoids comprised the majority of the radiolabel covalently ...
H D, Luján +3 more
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Protein and RNA inhibitors and protozoan habituation
Psychopharmacologia, 1970A variety of protein and RNA inhibitors were tested on habituation learning in the protozoan Spirostomum. Inhibition of protein synthesis up to values of 95% had no effect upon habituation, and RNA inhibition up to 89% by 5-fluorouracil had only slight effects upon it. Large amounts of protein and RNA synthesis are not necessary for habituation.
F T, Gardner, P B, Applewhite
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Pathogenic role of mitogen activated protein kinases in protozoan parasites
Biochimie, 2022Protozoan parasites with complex life cycles have high mortality rates affecting billions of human lives. Available anti-parasitic drugs are inadequate due to variable efficacy, toxicity, poor patient compliance and drug-resistance. Hence, there is an urgent need for the development of safer and better chemotherapeutics.
Pavneet, Kaur, Neena, Goyal
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Glycosylation of proteins in the protozoan Euglena gracilis
Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1985Abstract 1. 1. The main dolichol-P-P-bound oligosaccharide present in Euglena gracilis cells incubated with [U- 14 C]glucose was found to migrate on paper chromatography as a Glc 3 Man 9 GlcNAc 2 standard and to contain glucose, mannose and N- acetylglucosamine residues. 2. 2.
Laura de la Canal, Armando J. Parodi
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Protein synthesis and cell division in a pyrimidine-starved protozoan
Experimental Cell Research, 1960Abstract In media complete save for uracil, T. pyriformis continues to make protein, divide, and form normal cells, although its net RNA content does not increase. Uracil-starved cells rapidly regain their original RNA level when uracil is restored.
S, LEDERBERG, D, MAZIA
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