Heat Shock Proteins in Protozoan Parasites – Leishmania spp.
2009In this review, we shall look into the heat shock proteins of kinetoplastid protozoa of the genus Leishmania. The leishmaniae possess a full complement of molecular chaperones, with peculiar additions. Heat shock proteins play crucial roles in both parts of the biphasic life cycle, having an impact, both on the temperature-induced differentiation from ...
Gabi Ommen, Joachim Clos
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Characterization of Trichomonas vaginalis virus proteins in the pathogenic protozoan T. vaginalis
Archives of Virology, 1998The 4.6-kb double-stranded (ds) RNA of Trichomonas vaginalis virus (TVV)-T1 has been shown to encode two overlapping genes, cap and pol. In this study, a serum for specifically detecting viral cap gene product was raised against a recombinant protein, and sera for specifically detecting pol gene product were raised against synthetic oligopeptides. A 75-
H W, Liu, Y D, Chu, J H, Tai
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Large‐scale survey for potentially targetable indels in bacterial and protozoan proteins
Proteins: Structure, Function, and Bioinformatics, 2005AbstractOur previous results demonstrated that some essential, housekeeping proteins from pathogenic microorganisms may contain sizable insertions–deletions in their sequences (compared to close human homologs) that can be responsible for unexpected virulence properties.
Artem, Cherkasov +3 more
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Isotopic labeling of recombinant proteins expressed in the protozoan host Leishmania tarentolae
Protein Expression and Purification, 2006Isotope labeling of recombinant proteins is a prerequisite for application of nuclear magnetic resonance spectroscopy (NMR) for the characterization of the three-dimensional structures and dynamics of proteins. Overexpression of isotopically labeled proteins in bacterial or yeast host organisms has several drawbacks. In this work, we tested whether the
Niculae, A. +7 more
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In silico identification of the protein disulfide isomerase family from a protozoan parasite
Computational Biology and Chemistry, 2008Protein disulfide isomerase (PDI) enzymes are eukaryotic oxidoreductases that catalyze the correct formation of disulfide bonds during protein folding. Structurally they are characterized by the presence of functional thioredoxin-like (Trx) domains.
Marco A, Ramos +4 more
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Chemical tools for probing protein N-myristoylation in protozoan parasites
2013Protein N -myristoylation is the attachment of a 14-carbon fatty acid, myristate, onto the N-terminal residue of specific proteins. This co - and post-translational modification is catalysed by myristoyl CoA:protein N -myristoyltransferase (NMT), an essential enzyme in eukaryotes.
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Recombinant Protein Production in the Eukaryotic Protozoan Parasite Leishmania tarentolae: A Review
2011Leishmania tarentolae is a trypanosomatid protozoan parasite of the gecko, and has been established as a new eukaryotic expression system for the production of recombinant proteins. It seems that a protozoan parasite is a curious choice as the expression host; however, Trypanosomatidae are rich in glycoproteins with a pattern of glycosylation closely ...
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The emerging paradigm of calcium homeostasis as a new therapeutic target for protozoan parasites
Medicinal Research Reviews, 2022Yash Gupta +2 more
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Kinases as Druggable Targets in Trypanosomatid Protozoan Parasites
Chemical Reviews, 2014Kenneth D Stuart, Michael P Pollastri
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Sending a message: extracellular vesicles of pathogenic protozoan parasites
Nature Reviews Microbiology, 2016Rudo Kieft
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