Results 91 to 100 of about 13,226 (233)

Genetic identification of endogenous polytropic proviruses by using recombinant inbred mice [PDF]

Journal of Virology, 1989
Forty-seven endogenous polytropic murine viruses (Pmv) were identified by examination of proviral-cellular DNA junction fragment segregation in recombinant inbred (RI) mice. Most Pmv loci were found in more than one of the seven RI progenitor strains analyzed, but only four were present in all strains.
Frankel, W N, Stoye, J P, Taylor, B A, Coffin, J M   +3 more
openaire   +2 more sources

Discovery and characterization of complete genomes of 38 head-tailed proviruses in four predominant phyla of archaea

Microbiology Spectrum
Archaea play a significant role in natural ecosystems and the human body. Archaeal viruses exert a considerable influence on the structure and composition of archaeal communities and their associated ecological environments.
Tianqi Xu, Yimin Ni, Hailing Li, Shuang Wu, Shuling Yan, Lanming Chen, Yongxin Yu, Yongjie Wang   +7 more
doaj   +1 more source

Distinct gene expression by expanded clones of quiescent memory CD4 ⁺ T cells harboring intact latent HIV-1 proviruses [PDF]

, 2022
Georg H.J. Weymar, Yotam Bar‐On, Thiago Y. Oliveira, Christian Gaebler, Víctor Ramos, Harald Hartweger, Gaëlle Breton, Marina Caskey, Lillian B. Cohn, Mila Janković, Michel C. Nussenzweig   +10 more
openalex   +1 more source

Differential Expression of Human Endogenous Retroviruses‐W in Multiple Sclerosis and Epilepsy: A Comparative Study With Healthy Controls

Advances in Virology, Volume 2026, Issue 1, 2026.
Human endogenous retroviruses (HERVs) are the remnants of viral infections that occurred in our ancestors, subsequently integrated into the human genome. They make up about 8% of the human genome. Increased HERV expression occurs in physiological and pathological conditions, especially neurological diseases.
Sina Mahdavi, Vahdat Poortahmasebi, Daryoush Savadi Oskouei, Arezou Azadi, Sara Mafi, Javid Sadeghi, Hossein Bannazadeh Baghi, Mahin Ahangar Oskouee, Jasbir Arora (RSS)   +8 more
wiley   +1 more source

Silencing of proviruses in embryonic cells: efficiency, stability and chromatin modifications [PDF]

EMBO reports, 2012
Embryonic stem cells repress retroviral infection through transcriptional silencing of proviral DNAs. We characterized two distinct mechanisms of silencing in embryonic mouse cells infected by Moloney murine leukaemia virus (MLV): a highly efficient one targeting the proline transfer RNA primer‐binding site (PBSpro), and a less efficient one operating ...
Sharon, Schlesinger, Stephen P, Goff
openaire   +2 more sources

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

Molecular Oncology, Volume 19, Issue 12, Page 3750-3768, December 2025.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner, Markus Eckstein, Christoph Mark, Matthias W. Beckmann, Arndt Hartmann, Pamela L. Strissel, Reiner Strick   +6 more
wiley   +1 more source

Immune‐Related Protein and Non‐Coding RNA Cargo of Extracellular Vesicles Participate in the Chronic Inflammation Induced by HIV Infection

Journal of Extracellular Biology, Volume 4, Issue 12, December 2025.
ABSTRACT Extracellular vesicles (EVs) promote intercellular communication, playing a key role in the secondary immune‐related pathologies driven by chronic inflammation in people living with HIV (PLWH). To identify molecular components within large EVs (lEVs) from PLWH's plasma that may influence immune function and contribute to the pathological ...
Humberto Doriguêtto Gravina, Ricardo Cardoso Castro, Ana Margarida Gonçalves, Julia Oliveira Lima, Fabrícia Heloísa Cavicchioli Sugiyama, Brenda Cavalin Moreira, Mateus da Silva Matias Antunes, Caroline Fontanari, Valdes Roberto Bollela, Yann Yves Lamarre, Fausto Almeida, Simone Kashima, Margarida Saraiva, Nuno Osório, Fabiani Gai Frantz   +14 more
wiley   +1 more source

Recombinant origin and interspecies transmission of a HERV-K(HML-2)-related primate retrovirus with a novel RNA transport element

eLife
HERV-K(HML-2), the youngest clade of human endogenous retroviruses (HERVs), includes many intact or nearly intact proviruses, but no replication competent HML-2 proviruses have been identified in humans.
Zachary H Williams, Alvaro Dafonte Imedio, Lea Gaucherand, Derek C Lee, Salwa Mohd Mostafa, James P Phelan, John M Coffin, Welkin E Johnson   +7 more
doaj   +1 more source

Exploration of Human Skin Phageome to Reveal Endolysins and Novel Antimicrobial Peptides for Therapeutic Applications

MicrobiologyOpen, Volume 14, Issue 6, December 2025.
This study uncovers diverse endolysins and novel antimicrobial peptides from the human skin phageome, highlighting their potential to target antibiotic‐resistant pathogens and disrupt virulence mechanisms, paving the way for next‐generation skin therapeutics.
Jibon Kumar Paul, Arzuba Akter, Nurnabi Azad Jewel, Mohimenul Haque Rolin, Daniyal Karim, Raphael Kabir Niloy, Shakhinur Islam Mondal   +6 more
wiley   +1 more source

Defective and Wild-Type Human T-Cell Leukemia Virus Type I Proviruses: Characterization of Gene Products and trans-Interactions between Proviruses

Virology, 1999
Defective provirus genomes of human T-cell leukemia virus type I are frequently detected in lymphocytes from infected individuals and in infected cell lines. One type of defective provirus contains internal deletions spanning gag, pol, and env genes but retains portions of open reading frames for trans-regulatory proteins.
Shuh, Maureen, Hill, Shawn A., Derse, David   +2 more
openaire   +2 more sources