Results 101 to 110 of about 13,226 (233)

Importance of continuous monitoring of bovine leukaemia virus infection on farms in bovine leukaemia virus‐endemic areas of Japan

Veterinary Record Open, Volume 12, Issue 2, December 2025.
Abstract Background Enzootic bovine leukosis (EBL), caused by the bovine leukaemia virus (BLV), has exhibited increasing infection rates in Japan. While many farms implement various infection prevention measures, practical challenges—such as barn structure and availability of replacement cattle—can hinder farm purification efforts.
Chikako Tani, Jiazhou Li, Hirohisa Mekata, Kazuhiro Morishita, Shingo Nakahata   +4 more
wiley   +1 more source

Parallel analysis of transcription, integration, and sequence of single HIV-1 proviruses

Cell, 2022
Kevin B. Einkauf, Matt Osborn, Ce Gao, Weiwei Sun, Xiaoming Sun, Xiaodong Lian, Elizabeth M. Parsons, Gregory T. Gladkov, Kyra W. Seiger, Jane E. Blackmer, Chenyang Jiang, S. Yukl, E. Rosenberg, Xu G. Yu, M. Lichterfeld   +14 more
semanticscholar   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, Volume 599, Issue 21, Page 3012-3028, November 2025.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

[Transfection by integrated proviruses].

Voprosy virusologii, 1977
Three lines of continuous mouse L cells were compared: one of them contained only its endogenic oncornavirus, another was contaminated with SV5 virus, and a third was obtained from the second line chronically infected with vesicular stomatitis virus.
G P, Sovetova, M A, Iakhno, B V, Gushchin, U A, Abenova, V D, Solov'ev   +4 more
openaire   +1 more source

Primate immunodeficiency virus Vpx and Vpr counteract transcriptional repression of proviruses by the HUSH complex

Nature Microbiology, 2018
Host factors that silence provirus transcription in CD4+ memory T cells help HIV-1 escape eradication by the host immune system and by antiviral drugs1. These same factors, however, must be overcome for HIV-1 to propagate.
Leonid A Yurkovetskiy, M. H. Guney, Kyusik Q Kim, Shih Lin Goh, S. McCauley, Ann Dauphin, William E. Diehl, Jeremy Luban   +7 more
semanticscholar   +1 more source

Profound reduction of HIV-1 reservoir cells over 3 decades of antiretroviral therapy started in early infancy

JCI Insight
HIV-1 reservoir cells persist indefinitely during suppressive antiretroviral therapy (ART) in individuals who acquire infection in adulthood, but little is known about the longitudinal evolution of viral reservoir cells during long-term ART started ...
Liliana C. Vela, Leah Carrere, Chloe Naasz, Sruthi Kalavacherla, Toong Seng Tan, Lesley de Armas, Ce Gao, Xu G. Yu, Savita G. Pahwa, Katherine Luzuriaga, Mathias Lichterfeld   +10 more
doaj   +1 more source

Measuring replication competent HIV-1: advances and challenges in defining the latent reservoir

Retrovirology, 2018
Antiretroviral therapy cannot cure HIV-1 infection due to the persistence of a small number of latently infected cells harboring replication-competent proviruses.
Zheng Wang, Francesco R. Simonetti, Robert F. Siliciano, Gregory M. Laird   +3 more
doaj   +1 more source

Intact HIV Proviruses Persist in Children Seven to Nine Years after Initiation of Antiretroviral Therapy in the First Year of Life

Journal of Virology, 2019
There are limited data about the proviral landscape in children exhibiting long-term suppression after early treatment, particularly in Sub-Saharan Africa where HIV-1 subtype C predominates.
M. Katusiime, E. Halvas, I. Wright, K. Joseph, Michael J. Bale, B. Kirby-McCullough, S. Engelbrecht, W. Shao, Wei-Shau Hu, M. Cotton, J. Mellors, Mary F. Kearney, G. V. Van Zyl   +12 more
semanticscholar   +1 more source

Characterization of Intact Proviruses in Blood and Lymph Node from HIV-Infected Individuals Undergoing Analytical Treatment Interruption

Journal of Virology, 2018
HIV-1 persists as a latent infection in CD4+ T cells that can be found in lymphoid tissues in infected individuals during ART. However, the importance of this tissue reservoir and its contribution to viral rebound upon ART interruption are not clear.
Line K. Vibholm, Julio C. C. Lorenzi, J. Pai, Yehuda Z. Cohen, Thiago Y. Oliveira, J. Barton, Marco Garcia Noceda, Ching-Lan Lu, Y. Ablanedo-Terrazas, P. M. Del Rio Estrada, G. Reyes-Terán, M. Tolstrup, P. W. Denton, T. Damsgaard, O. Søgaard, M. Nussenzweig   +15 more
semanticscholar   +1 more source

Relationship between intact HIV-1 proviruses in circulating CD4+ T cells and rebound viruses emerging during treatment interruption

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance The HIV-1 latent reservoir is the major barrier to cure. Analysis of the replication competent latent reservoir that can be induced in viral outgrowth assays (VOAs) showed little or no overlap with HIV viruses that emerge in plasma after ...
Ching-Lan Lu, J. Pai, Lilian Nogueira, Pilar Mendoza, H. Gruell, Thiago Y. Oliveira, J. Barton, J. C. Lorenzi, Yehuda Z. Cohen, Lillian B. Cohn, F. Klein, M. Caskey, M. Nussenzweig, M. Jankovic   +13 more
semanticscholar   +1 more source