Results 111 to 120 of about 18,625 (239)

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, Volume 600, Issue 3, Page 342-355, February 2026.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

Characterization of Intact Proviruses in Blood and Lymph Node from HIV-Infected Individuals Undergoing Analytical Treatment Interruption. [PDF]

, 2019
The role of lymphoid tissue as a potential source of HIV-1 rebound following interruption of antiretroviral therapy (ART) is uncertain. To address this issue, we compared the latent viruses obtained from CD4+ T cells in peripheral blood and lymph nodes ...
Ablanedo-Terrazas, Yuria, Barton, John P, Cohen, Yehuda Z, Damsgaard, Tine, Del Rio Estrada, Perla M, Denton, Paul W, Garcia Noceda, Marco, Lorenzi, Julio CC, Lu, Ching-Lan, Nussenzweig, Michel C, Oliveira, Thiago Y, Pai, Joy A, Reyes-Teran, Gustavo, Søgaard, Ole S, Tolstrup, Martin, Vibholm, Line K   +15 more
core   +1 more source

HIV-1 latent reservoir: size matters. [PDF]

, 2016
More than 35 million people remain infected with HIV-1. Upon antiretroviral therapy cessation, HIV-1-positive individuals systematically fail to achieve sustained virological remission, revealing the presence of a reservoir.
Ciuffi, A., Hodel, F., Patxot, M., Snäkä, T.   +3 more
core   +1 more source

Recent Developments in HIV Antivirals: The Prospect of Prophylactic Drugs to Change the Pandemic

Microbial Biotechnology, Volume 19, Issue 2, February 2026.
Replication cycle of HIV‐1. The scheme provides an overview from virus entry over reverse transcription of viral RNA into viral DNA, provirus DNA integration into the host genome, genome expression by transcription and translation, proteolytic processing of the viral polyproteins, viral maturation to viral release from the cell. The various targets for
Harald Brüssow
wiley   +1 more source

Genetic identification of endogenous polytropic proviruses by using recombinant inbred mice [PDF]

Journal of Virology, 1989
Forty-seven endogenous polytropic murine viruses (Pmv) were identified by examination of proviral-cellular DNA junction fragment segregation in recombinant inbred (RI) mice. Most Pmv loci were found in more than one of the seven RI progenitor strains analyzed, but only four were present in all strains.
Frankel, W N, Stoye, J P, Taylor, B A, Coffin, J M   +3 more
openaire   +2 more sources

Estrogen receptor-1 is a key regulator of HIV-1 latency that imparts gender-specific restrictions on the latent reservoir. [PDF]

, 2018
Unbiased shRNA library screens revealed that the estrogen receptor-1 (ESR-1) is a key factor regulating HIV-1 latency. In both Jurkat T cells and a Th17 primary cell model for HIV-1 latency, selective estrogen receptor modulators (SERMs, i.e ...
Bacchetti, Peter, Chomont, Nicolas, Das, Biswajit, Deeks, Steven G, Dobrowolski, Curtis, Gandhi, Monica, Hoh, Rebecca, Johnston, Rowena, Karn, Jonathan, Luttge, Benjamin, Scully, Eileen, Valadkhan, Saba   +11 more
core  

DNA double strand break repair enzymes function at multiple steps in retroviral infection [PDF]

, 2009
(c) 2009 Sakurai et al; licensee BioMed Central Ltd. / This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and ...
Sakurai Yasuteru, Komatsu Kenshi, Agematsu Kazunaga, Matsuoka Masao   +3 more
core   +4 more sources

Diversity, Function and Activity of DNA Viruses in the Qiangyong Proglacial Lake Sediment, the Tibetan Plateau

Environmental Microbiology Reports, Volume 18, Issue 1, February 2026.
This study identified DNA viruses from Qiangyong proglacial lake sediments on the Tibetan Plateau, revealing a highly diverse and previously uncharacterized viral community. These viruses influence microbial community structure and function by infecting key nutrient‐transforming taxa and encoding auxiliary metabolic genes that modulate host metabolism.
Yang Zhao, Meiling Feng, Hongfei Chi, Keshao Liu, Rong Wen, Weizhen Zhang, Pengfei Liu   +6 more
wiley   +1 more source

Silencing of proviruses in embryonic cells: efficiency, stability and chromatin modifications [PDF]

EMBO reports, 2012
Embryonic stem cells repress retroviral infection through transcriptional silencing of proviral DNAs. We characterized two distinct mechanisms of silencing in embryonic mouse cells infected by Moloney murine leukaemia virus (MLV): a highly efficient one targeting the proline transfer RNA primer‐binding site (PBSpro), and a less efficient one operating ...
Sharon, Schlesinger, Stephen P, Goff
openaire   +2 more sources

Intramolecular integration within Moloney murine leukemia virus DNA [PDF]

, 1981
By screening a library of unintegrated, circular Moloney murine leukemia virus (M-MuLV) DNA cloned in lambda phage, we found that approximately 20% of the M-MuLV DNA inserts contained internal sequence deletions or inversions.
Baltimore, David, Goff, Stephen P., Hoffmann, Joseph, Shoemaker, Charles   +3 more
core