Results 141 to 150 of about 18,625 (239)

Cis-perturbation of cancer drivers by the HTLV-1/BLV proviruses is an early determinant of leukemogenesis

Nature Communications, 2017
Human T-cell leukaemia virus type-1 (HTLV-1) and bovine leukaemia virus (BLV) infect T- and B-lymphocytes, respectively, provoking a polyclonal expansion that will evolve into an aggressive monoclonal leukaemia in ∼5% of individuals following a ...
N. Rosewick, K. Durkin, M. Artesi, A. Marçais, V. Hahaut, P. Griebel, N. Arsic, V. Avettand-Fenoel, A. Burny, C. Charlier, O. Hermine, M. Georges, A. Van den Broeke   +12 more
semanticscholar   +1 more source

Host-linked soil viral ecology along a permafrost thaw gradient [PDF]

, 2018
Climate change threatens to release abundant carbon that is sequestered at high latitudes, but the constraints on microbial metabolisms that mediate the release of methane and carbon dioxide are poorly understood1,2,3,4,5,6,7.
Bolduc, Benjamin, Boyd, Joel A., Brum, Jennifer R., Chanton, Jeffrey P., Crill, Patrick M., Emerson, Joanne B., Frolking, Stephen E., Hodgkins, Suzanne B., Jang, Ho Bin, Li, Changsheng, Naas, Adrian E., Pope, Phillip B., Rich, Virginia I., Roux, Simon, Saleska, Scott R., Singleton, Caitlin M., Solden, Lindsey M., Sullivan, Matthew B., Trubl, Gareth, Tyson, Gene W., Wilson, Rachel M., Woodcroft, Ben J., Wrighton, Kelly C.   +22 more
core   +1 more source

Genetic Diversity, Compartmentalization, and Age of HIV Proviruses Persisting in CD4+ T Cell Subsets during Long-Term Combination Antiretroviral Therapy

Journal of Virology, 2019
The main barrier to HIV cure is the ability of a genetically diverse pool of proviruses, integrated into the genomes of infected CD4+ T cells, to persist despite long-term suppressive combination antiretroviral therapy (cART).
B. Jones, Rachel L. Miller, N. Kinloch, O. Tsai, H. Rigsby, H. Sudderuddin, A. Shahid, B. Ganase, C. Brumme, M. Harris, A. Poon, M. Brockman, R. Fromentin, N. Chomont, J. Joy, Z. Brumme   +15 more
semanticscholar   +1 more source

Amplification of Near Full-length HIV-1 Proviruses for Next-Generation Sequencing

Journal of Visualized Experiments, 2018
The Full-Length Individual Proviral Sequencing (FLIPS) assay is an efficient and high-throughput method designed to amplify and sequence single, near full-length (intact and defective), HIV-1 proviruses.
B. Hiener, John-Sebastian Eden, B. Horsburgh, S. Palmer   +3 more
semanticscholar   +1 more source

Identification of a novel HERV-K(HML10): comprehensive characterization and comparative analysis in non-human primates provide insights about HML10 proviruses structure and diffusion

Mobile DNA, 2017
BackgroundAbout half of the human genome is constituted of transposable elements, including human endogenous retroviruses (HERV). HERV sequences represent the 8% of our genetic material, deriving from exogenous infections occurred millions of years ago ...
Nicole Grandi, M. Cadeddu, Maria Paola Pisano, F. Esposito, J. Blomberg, E. Tramontano   +5 more
semanticscholar   +1 more source

Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles [PDF]

, 1996
Notch is a highly conserved transmembrane protein that is involved in cell fate decisions and is found in organisms ranging from Drosophila to humans. A human homologue of Notch, TAN1, was initially identified at the chromosomal breakpoint of a subset of
Aster, Jon C., Baltimore, David, Hasserjian, Robert P., Pear, Warren S., Scott, Martin L., Sklar, Jeffrey, Soffer, Benny   +6 more
core  

Measuring integrated HIV DNA ex vivo and in vitro provides insights about how reservoirs are formed and maintained

Retrovirology, 2018
The identification of the most appropriate marker to measure reservoir size has been a great challenge for the HIV field. Quantitative viral outgrowth assay (QVOA), the reference standard to quantify the amount of replication-competent virus, has several
Marilia Rita Pinzone, Una O’Doherty
doaj   +1 more source

Insights into the mechanisms underlying the inactivation of HIV-1 proviruses by CRISPR/Cas.

Virology, 2018
DNA editing using CRISPR/Cas has emerged as a potential treatment for diseases caused by pathogenic human DNA viruses. One potential target is HIV-1, which replicates via a chromosomally integrated DNA provirus.
Adam L Mefferd, H. Bogerd, I. Irwan, B. Cullen   +3 more
semanticscholar   +1 more source

The role of integration and clonal expansion in HIV infection: live long and prosper

Retrovirology, 2018
Integration of viral DNA into the host genome is a central event in the replication cycle and the pathogenesis of retroviruses, including HIV. Although most cells infected with HIV are rapidly eliminated in vivo, HIV also infects long-lived cells that ...
Elizabeth M. Anderson, Frank Maldarelli
doaj   +1 more source

Evolutionary Genomics of Prokaryotic Viruses [PDF]

, 2010
Evolutionary history of biological entities is recorded within their nucleic acid sequences and can (sometimes) be deciphered by thorough genomic analysis.
Krupovic, Mart
core