Results 21 to 30 of about 13,226 (233)

Expression of HERV-K proviruses in human leukocytes [PDF]

Blood, 1993
Abstract HERV-K is a 50-copy, human endogenous, class 1 retroviral element that contains some polycistrons with gag, pol, and env open reading frames. Although expression of HERV-K proviruses has been shown in cultured human cell lines, expression of these elements has not been shown in human blood leukocytes.
I Brodsky, Brian Foley, Dale Haines, J Johnston, Kevin Cuddy, David A. Gillespie   +5 more
  +6 more sources

Proviruses in CD4⁺ T cells reactive to autologous antigens contribute to nonsuppressible HIV-1 viremia. [PDF]

Sci Transl Med
Wu F, Moskovljevic M, Dragoni F, Jayaraman S, Board NL, Camilo-Contreras A, Bernal S, Hariharan V, Zhang H, Lai J, Singhal A, Poulin S, Chano F, Chamberland A, Tremblay C, Zoltick M, Hoffmann CJ, Jones JL, Larman HB, Montaner LJ, Siliciano JD, Siliciano RF, Simonetti FR.   +22 more
europepmc   +3 more sources

Endogenous proviruses as “mementos”? [PDF]

Nature, 1997
In a recent News and Views1, J. P. Stoye discussed the potential health risks associated with the spread of endogenous proviruses from pigs and primates through the use of their organs for transplantation into humans. Although the risks to patients and the public from horizontal transmission may be as manageable as he represents, we would like to ...
Charles H. Langley, Brian Charlesworth
  +5 more sources

Superinfection promotes replication and diversification of defective HIV-1 proviruses in people with non-suppressible viraemia. [PDF]

Nat Microbiol
Hariharan V, White JA, Dragoni F, Fray EJ, Pathoulas N, Moskovljevic M, Zhang H, Singhal A, Lai J, Beg SA, Scully EP, Gilliams EA, Block DS, Keruly J, Moore RD, Siliciano JD, Simonetti FR, Siliciano RF.   +17 more
europepmc   +3 more sources

DNA methylation affecting the expression of murine leukemia proviruses [PDF]

Journal of Virology, 1982
The endogenous, vertically transmitted proviral DNAs of the ecotropic murine leukemia virus in AKR embryo fibroblasts were found to be hypermethylated relative to exogenous AKR murine leukemia virus proviral DNAs acquired by infection of the same cells.
Joseph W. Hoffmann, David L. Steffen, James F. Gusella, Clifford J. Tabin, Stephanie J. Bird, Deborah W. Cowing, Robert A. Weinberg   +6 more
openalex   +4 more sources

Unequal distribution of genetically-intact HIV-1 proviruses in cells expressing the immune checkpoint markers PD-1 and/or CTLA-4

Frontiers in Immunology, 2023
IntroductionHIV-1 persists in resting CD4+ T-cells despite antiretroviral therapy (ART). Determining the cell surface markers that enrich for genetically-intact HIV-1 genomes is vital in developing targeted curative strategies.
Katie Fisher, Katie Fisher, Timothy E. Schlub, Zoe Boyer, Zoe Boyer, Thomas A. Rasmussen, Thomas A. Rasmussen, Ajantha Rhodes, Rebecca Hoh, Frederick M. Hecht, Steven G. Deeks, Sharon R. Lewin, Sharon R. Lewin, Sharon R. Lewin, Sarah Palmer, Sarah Palmer   +15 more
doaj   +1 more source

Comparative HIV-1 Proviral Dynamics in Two Individuals That Maintained Viral Replication Control with or without Antiretroviral Therapy following Superinfection

Viruses, 2022
The analysis of the HIV-1 proviral dynamics after superinfection in the context of both natural and antiretroviral therapy (ART)-mediated suppression could yield unique insights into understanding the persistence of viral variants that seeded the ...
Suwellen Sardinha Dias de Azevedo, Fernanda H. Côrtes, Larissa M. Villela, Brenda Hoagland, Beatriz Grinsztejn, Valdilea G. Veloso, Mariza G. Morgado, Gonzalo Bello   +7 more
doaj   +1 more source

Long-term persistence of transcriptionally active ‘defective’ HIV-1 proviruses: implications for persistent immune activation during antiretroviral therapy

AIDS (London), 2023
Objectives: People with HIV-1 (PWH) on effective antiretroviral therapy (ART) continue to exhibit chronic systemic inflammation, immune activation, and persistent elevations in markers of HIV-1 infection [including HIV-DNA, cell-associated HIV-RNA (CA ...
Kanal Singh, V. Natarajan, R. Dewar, Adam W. Rupert, Yuden Badralmaa, Tracey Zhai, Nicole E Winchester, F. Scrimieri, Mindy Smith, I. Davis, P. Lallemand, Aude Giglietti, Jack M. Hensien, T. Buerkert, Bruktawit A. Goshu, C. Rehm, Zonghui Hu, H. Lane, H. Imamichi   +18 more
semanticscholar   +1 more source

The largest HIV-1-infected T cell clones in children on long-term combination antiretroviral therapy contain solo LTRs

mBio, 2023
Combination antiretroviral therapy (cART) suppresses viral replication but does not cure HIV infection because a reservoir of infectious (intact) HIV proviruses persists in long-lived CD4+T cells.
Johannes C. Botha, Dimiter Demirov, Carli Gordijn, Mary Grace Katusiime, Michael J. Bale, Xiaolin Wu, Daria Wells, Stephen H. Hughes, Mark F. Cotton, John W. Mellors, Mary F. Kearney, Gert U. van Zyl   +11 more
doaj   +1 more source

Age-Associated Expansion of HIV/SIV Reservoirs in People With HIV and SIV-Infected Macaques. [PDF]

Aging Cell
Virally suppressed older people with HIV have larger peripheral blood CD4+ T‐cell reservoirs than younger individuals, correlating with CD4+ and CD8+ T‐cell activation. Similar results were seen in SIV‐infected, ART‐treated aged rhesus macaques. ABSTRACT With the advancement of combination antiretroviral therapy (ART), over 50% of people with HIV (PWH)
Acharya A, Sutar D, Mohan M, Govind V, Villinger F, Pallikkuth S, Byrareddy SN.   +6 more
europepmc   +2 more sources