Results 41 to 50 of about 18,625 (239)

Effector memory differentiation increases detection of replication-competent HIV-l in resting CD4+ T cells from virally suppressed individuals. [PDF]

, 2019
Studies have demonstrated that intensive ART alone is not capable of eradicating HIV-1, as the virus rebounds within a few weeks upon treatment interruption.
Bale, Michael J, Busch, Michael P, Cox, Bryan, Deeks, Steven G, Hoh, Rebecca, Kearney, Mary F, Kulpa, Deanna A, Lackman-Smith, Carol, Maldarelli, Frank, Ptak, Roger G, Stone, Mars, Subramanian, Krupa, Wiegand, Ann, Wonderlich, Elizabeth R   +13 more
core   +1 more source

The baboon endogenous virus genome. II. Provirus sequence variations in baboon cell DNA [PDF]

, 1980
Restriction analysis of the approximately 100 integrated baboon endogenous virus (BaEV) proviruses in baboon cells and tissues has revealed two major sequence variations, both in the gag gene region of the genome.
Cohen, Maurice, Davidson, Norman, Gilden, Raymond V., McAllister, Robert M., Nicolson, Margery O., Stephens, Robert M.   +5 more
core   +1 more source

Deep Sequencing Analysis of Individual HIV-1 Proviruses Reveals Frequent Asymmetric Long Terminal Repeats

Journal of Virology, 2022
The integration of human immunodeficiency virus type 1 (HIV-1) into chromosomal DNA establishes the long-term persistence of HIV-1 as proviruses despite effective antiretroviral therapy (ART).
K. Joseph, E. Halvas, L. Brandt, S. Patro, J. Rausch, A. Chopra, S. Mallal, Mary F. Kearney, J. Coffin, J. Mellors   +9 more
semanticscholar   +1 more source

Complete genome sequences of two feline Leukemia virus subgroup B isolates with novel recombination sites [PDF]

, 2013
It is generally accepted that all primary isolates of feline leukemia virus (FeLV) contain a subgroup A virus (FeLV-A) that is essential for transmission.
Bae, Berry, Busch, Canfield, McDougall, Miyazawa, Niman, Roca, Sarma, Sheets, Stewart, Stewart, Wilson   +12 more
core   +1 more source

Signatures of immune selection in intact and defective proviruses distinguish HIV-1 elite controllers

Science Translational Medicine, 2021
Description Immune selection footprints in proviral sequences distinguish individuals with natural, drug-free control of HIV-1. Understanding elite controllers Some individuals living with HIV-1 are able to control viral loads without the need for ...
Xiao-lan Lian, Ce Gao, Xiaoming Sun, Chenyan Jiang, Kevin B. Einkauf, Kyra W. Seiger, Joshua M. Chevalier, Y. Yuki, Maureen P. Martin, R. Hoh, M. Peluso, Mary Carrington, E. Ruiz-Mateos, S. Deeks, E. Rosenberg, B. Walker, M. Lichterfeld, Xu G. Yu   +17 more
semanticscholar   +1 more source

Expression of HERV-K proviruses in human leukocytes [PDF]

Blood, 1993
Abstract HERV-K is a 50-copy, human endogenous, class 1 retroviral element that contains some polycistrons with gag, pol, and env open reading frames. Although expression of HERV-K proviruses has been shown in cultured human cell lines, expression of these elements has not been shown in human blood leukocytes.
I, Brodsky, B, Foley, D, Haines, J, Johnston, K, Cuddy, D, Gillespie   +5 more
openaire   +3 more sources

Low Inducibility of Latent Human Immunodeficiency Virus Type 1 Proviruses as a Major Barrier to Cure.

Journal of Infectious Diseases, 2021
The latent reservoir for human immunodeficiency virus type 1 (HIV-1) in resting CD4+ T cells is a major barrier to cure. The dimensions of the reservoir problem can be defined with 2 assays.
J. Siliciano, R. Siliciano
semanticscholar   +1 more source

Defective HIV-1 genomes and their potential impact on HIV pathogenesis

Retrovirology, 2022
Defective HIV-1 proviruses represent a population of viral genomes that are selected for by immune pressures, and clonally expanded to dominate the persistent HIV-1 proviral genome landscape.
Jeffrey Kuniholm, Carolyn Coote, Andrew J. Henderson   +2 more
doaj   +1 more source

Tracking HIV-1-Infected Cell Clones Using Integration Site-Specific qPCR

Viruses, 2021
Efforts to cure HIV-1 infection require better quantification of the HIV-1 reservoir, particularly the clones of cells harboring replication-competent (intact) proviruses, termed repliclones.
Leah D. Brandt, Shuang Guo, Kevin W. Joseph, Jana L. Jacobs, Asma Naqvi, John M. Coffin, Mary F. Kearney, Elias K. Halvas, Xiaolin Wu, Stephen H. Hughes, John W. Mellors   +10 more
doaj   +1 more source

A linkage map of endogenous murine leukemia proviruses. [PDF]

Genetics, 1990
Abstract Thirty endogenous proviruses belonging to the modified polytropic (Mpmv) class of murine leukemia virus (MLV) were identified by proviral-cellular DNA junction fragment segregation in several sets of recombinant inbred mice. Twenty-six Mpmv loci were mapped to chromosomal regions by matching proviral strain distribution patterns
Frankel, W N, Stoye, J P, Taylor, B A, Coffin, J M   +3 more
openaire   +2 more sources