Results 51 to 60 of about 18,625 (239)

A highly multiplexed droplet digital PCR assay to measure the intact HIV-1 proviral reservoir

Cell Reports Medicine, 2021
Summary: Quantifying the replication-competent HIV reservoir is essential for evaluating curative strategies. Viral outgrowth assays (VOAs) underestimate the reservoir because they fail to induce all replication-competent proviruses.
Claire N. Levy, Sean M. Hughes, Pavitra Roychoudhury, Daniel B. Reeves, Chelsea Amstuz, Haiying Zhu, Meei-Li Huang, Yulun Wei, Marta E. Bull, Noah A.J. Cassidy, Jan McClure, Lisa M. Frenkel, Mars Stone, Sonia Bakkour, Elizabeth R. Wonderlich, Michael P. Busch, Steven G. Deeks, Joshua T. Schiffer, Robert W. Coombs, Dara A. Lehman, Keith R. Jerome, Florian Hladik   +21 more
doaj   +1 more source

Distribution, diversity and evolution of endogenous retroviruses in perissodactyl genomes [PDF]

, 2018
The evolution of mammalian genomes has been shaped by interactions with endogenous retroviruses (ERVs). In this study, we investigated the distribution and diversity of ERVs in the mammalian order Perissodactyla, with a view to understanding their impact
Gifford, Robert, Murcia, Pablo Ramiro, Zhu, Henan   +2 more
core   +1 more source

HIVIntact: a python-based tool for HIV-1 genome intactness inference

Retrovirology, 2021
The characterisation of the HIV-1 reservoir, which consists of replication-competent integrated proviruses that persist on antiretroviral therapy (ART), is made difficult by the rarity of intact proviruses relative to those that are defective.
Imogen A. Wright, Michael J. Bale, Wei Shao, Wei-Shau Hu, John M. Coffin, Gert U. Van Zyl, Mary F. Kearney   +6 more
doaj   +1 more source

Insights from Clonal Expansion and HIV Persistence in Perinatal Infections

mBio, 2021
The latent HIV reservoir forms early in the course of infection and is maintained for life despite effective antiretroviral treatment (ART), including early treatment.
Adit Dhummakupt, Deborah Persaud
doaj   +1 more source

Different human resting memory CD4+ T cell subsets show similar low inducibility of latent HIV-1 proviruses

Science Translational Medicine, 2020
Latent replication-competent HIV-1 proviruses in different memory T cell subsets show no differences in viral gene transcription after T cell activation.
K. J. Kwon, Andrew E Timmons, Srona Sengupta, F. Simonetti, Hao Zhang, R. Hoh, S. Deeks, J. Siliciano, R. Siliciano   +8 more
semanticscholar   +1 more source

Activation of HIV-1 proviruses increases downstream chromatin accessibility

iScience, 2022
It is unclear how the activation of HIV-1 transcription affects chromatin structure. We interrogated chromatin organization both genome-wide and nearby HIV-1 integration sites using Hi-C and ATAC-seq. In conjunction, we analyzed the transcription of the HIV-1 genome and neighboring genes.
Raven Shah, Christian M. Gallardo, Yoonhee H. Jung, Ben Clock, Jesse R. Dixon, William M. McFadden, Kinjal Majumder, David J. Pintel, Victor G. Corces, Bruce E. Torbett, Philip R. Tedbury, Stefan G. Sarafianos   +11 more
openaire   +2 more sources

DNA methylation affecting the expression of murine leukemia proviruses [PDF]

Journal of Virology, 1982
The endogenous, vertically transmitted proviral DNAs of the ecotropic murine leukemia virus in AKR embryo fibroblasts were found to be hypermethylated relative to exogenous AKR murine leukemia virus proviral DNAs acquired by infection of the same cells.
Hoffmann, J W, Steffen, D, Gusella, J, Tabin, C, Bird, T, Cowing, D, Weinberg, R A   +6 more
openaire   +2 more sources

The Nature of the HTLV-1 Provirus in Naturally Infected Individuals Analyzed by the Viral DNA-Capture-Seq Approach

Cell Reports, 2019
Summary: The retrovirus human T-cell leukemia virus type 1 (HTLV-1) integrates into the host DNA, achieves persistent infection, and induces human diseases.
Hiroo Katsuya, Saiful Islam, Benjy Jek Yang Tan, Jumpei Ito, Paola Miyazato, Misaki Matsuo, Yuki Inada, Saori C. Iwase, Yoshikazu Uchiyama, Hiroyuki Hata, Tomoo Sato, Naoko Yagishita, Natsumi Araya, Takaharu Ueno, Kisato Nosaka, Masahito Tokunaga, Makoto Yamagishi, Toshiki Watanabe, Kaoru Uchimaru, Jun-ichi Fujisawa, Atae Utsunomiya, Yoshihisa Yamano, Yorifumi Satou   +22 more
doaj   +1 more source

Hide and seek: for HIV-infected CD4+ T cells, playing well comes with maturity

The Journal of Clinical Investigation, 2022
Antiretroviral therapy suppresses HIV replication but leaves a population of infected CD4+ T cells with integrated proviruses. While most of these proviruses contain defects, such as deletions, some intact proviruses persist and can reinitiate viral ...
Louise Leyre, R. Brad Jones
doaj   +1 more source

Insertional activation of STAT3 and LCK by HIV-1 proviruses in T cell lymphomas

Science Advances, 2021
HIV-1 proviruses in the first introns of STAT3 and LCK can contribute to the development of T cell lymphomas.
J. Mellors, Shuang Guo, Asma Naqvi, L. Brandt, Ling Su, Zhonghe Sun, K. Joseph, D. Demirov, E. Halvas, D. Butcher, Beth A. Scott, A. Hamilton, Marintha Heil, Baktiar O Karim, Xiaolin Wu, S. Hughes   +15 more
semanticscholar   +1 more source