Results 61 to 70 of about 13,226 (233)

Cellular Activation, Differentiation, and Proliferation Influence the Dynamics of Genetically Intact Proviruses Over Time

Journal of Infectious Diseases, 2021
Human immunodeficiency virus (HIV) persists in cells despite antiretroviral therapy; however, the influence of cellular mechanisms such as activation, differentiation, and proliferation upon the distribution of proviruses over time is unclear. To address
B. Horsburgh, B. Hiener, K. Fisher, Eunok Lee, Hannah Morgan, John-Sebastian Eden, S. von Stockenstrom, L. Odevall, J. Milush, R. Hoh, R. Fromentin, N. Chomont, F. Hecht, T. Schlub, S. Deeks, S. Palmer   +15 more
semanticscholar   +1 more source

Screening and Identification of Human Endogenous Retrovirus-K mRNAs for Breast Cancer Through Integrative Analysis of Multiple Datasets

Frontiers in Oncology, 2022
ObjectiveHuman endogenous retroviruses (HERVs) make up 8% of the human genome. HERVs are biologically active elements related to multiple diseases.
Yongzhong Wei, Huilin Wei, Yinfeng Wei, Aihua Tan, Xiuyong Chen, Xiuquan Liao, Bo Xie, Xihua Wei, Lanxiang Li, Zengjing Liu, Shengkang Dai, Adil Khan, Xianwu Pang, Nada M. A. Hassan, Kai Xiong, Kai Zhang, Jing Leng, Jiannan Lv, Yanling Hu, Yanling Hu   +19 more
doaj   +1 more source

People Living With HIV Have More Intact HIV DNA in Circulating CD4+ T Cells if They Have History of Pulmonary Tuberculosis

Pathogens and Immunity
Background: A primary barrier to curing HIV is the HIV reservoir. The leading infectious cause of death worldwide for people living with HIV is tuberculosis (TB), but we do not know how TB impacts the HIV reservoir.
Marc Antoine Jean Juste, Yvetot Joseph, Dominique Lespinasse, Alexandra Apollon, Parmida Jamshidi, Myung Hee Lee, Maureen Ward, Esther Brill, Yanique Duffus, Uche Chukwukere, Ali Danesh, Winiffer Alberto, Daniel Fitzgerald, Jean Pape, R Jones, Kathryn Dupnik   +15 more
doaj   +1 more source

The Novel Halovirus Hardycor1, and the Presence of Active (Induced) Proviruses in Four Haloarchaea

Genes, 2021
The virus Hardycor1 was isolated in 1998 and infects the haloarchaeon Halorubrum coriense. DNA from a frozen stock (HC1) was sequenced and the viral genome found to be 45,142 bp of dsDNA, probably having redundant, circularly permuted termini. The genome
M. Dyall-Smith, F. Pfeiffer, Pei-Wen Chiang, Sen-Lin Tang   +3 more
semanticscholar   +1 more source

T cell stimulation remodels the latently HIV-1 infected cell population by differential activation of proviral chromatin.

PLoS Pathogens, 2022
The reservoir of latently HIV-1 infected cells is heterogeneous. To achieve an HIV-1 cure, the reservoir of activatable proviruses must be eliminated while permanently silenced proviruses may be tolerated.
Birgitta Lindqvist, Bianca B Jütte, Luca Love, Wlaa Assi, Julie Roux, Anders Sönnerborg, Tugsan Tezil, Eric Verdin, J Peter Svensson   +8 more
doaj   +1 more source

Improved Detection of HIV Gag p24 Protein Using a Combined Immunoprecipitation and Digital ELISA Method

Frontiers in Microbiology, 2021
Greater than 90% of HIV-1 proviruses are thought to be defective and incapable of viral replication. While replication competent proviruses are of primary concern with respect to disease progression or transmission, studies have shown that even defective
Guoxin Wu, Carol Cheney, Qian Huang, Daria J. Hazuda, Bonnie J. Howell, Paul Zuck   +5 more
doaj   +1 more source

Aging-associated patterns in the expression of human endogenous retroviruses.

PLoS ONE, 2018
Human endogenous retroviruses (HERV) are relics of ancient retroviral infections in our genome. Most of them have lost their coding capacity, but proviral RNA or protein have been observed in several disease states (e.g.
Tapio Nevalainen, Arttu Autio, Binisha Hamal Mishra, Saara Marttila, Marja Jylhä, Mikko Hurme   +5 more
doaj   +1 more source

HIV Infected T Cells Can Proliferate in vivo Without Inducing Expression of the Integrated Provirus

Frontiers in Microbiology, 2019
BackgroundHIV-1 proviruses can persist during ART in clonally-expanded populations of CD4+ T cells. To date, few examples of an expanded clones containing replication-competent proviruses exist, although it is suspected to be common.
Andrew Musick, Jonathan Spindler, Eli Boritz, Liliana Pérez, Daniel Crespo-Vélez, Sean C. Patro, Michele D. Sobolewski, Michael J. Bale, Carolyn Reid, Brandon F. Keele, Adam Capoferri, Wei Shao, Ann Wiegand, Francesco R. Simonetti, John W. Mellors, Stephen H. Hughes, John M. Coffin, Frank Maldarelli, Mary F. Kearney   +18 more
doaj   +1 more source

Integration in oncogenes plays only a minor role in determining the in vivo distribution of HIV integration sites before or during suppressive antiretroviral therapy.

PLoS Pathogens, 2021
HIV persists during antiretroviral therapy (ART) as integrated proviruses in cells descended from a small fraction of the CD4+ T cells infected prior to the initiation of ART.
John M Coffin, Michael J Bale, Daria Wells, Shuang Guo, Brian Luke, Jennifer M Zerbato, Michele D Sobolewski, Twan Sia, Wei Shao, Xiaolin Wu, Frank Maldarelli, Mary F Kearney, John W Mellors, Stephen H Hughes   +13 more
doaj   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source