Results 61 to 70 of about 18,625 (239)

New Approaches to Multi-Parametric HIV-1 Genetics Using Multiple Displacement Amplification: Determining the What, How, and Where of the HIV-1 Reservoir

Viruses, 2021
Development of potential HIV-1 curative interventions requires accurate characterization of the proviral reservoir, defined as host-integrated viral DNA genomes that drive rebound of viremia upon halting ART (antiretroviral therapy).
Sean C. Patro, Aurelie Niyongabo, Frank Maldarelli, Mary F. Kearney   +3 more
doaj   +1 more source

Impact of BoLA-DRB3 Polymorphisms on Clonality of Bovine Leukaemia Virus-Infected Cells of Cattle With Lymphoma. [PDF]

HLA
ABSTRACT Bovine leukaemia virus (BLV) infects cattle, integrates into the host genome as a provirus, and induces a persistent infection that remains asymptomatic but can cause leukaemia/lymphoma. Most BLV‐infected cell clones are created by massive depletion, and a few of these infected cell clones expand through the mitotic cycle, leading to the onset
Fukushi N, Yamanaka MP, Matsuura R, Watanuki S, Saito S, Matsumoto Y, Fukumoto K, Hosomichi K, Wang J, Takeshima SN, Aida Y.   +10 more
europepmc   +2 more sources

Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy

Journal of Clinical Investigation, 2019
Chromosomal integration of genome-intact HIV-1 sequences into the host genome creates a reservoir of virally infected cells that persists throughout life, necessitating indefinite antiretroviral suppression therapy.
Kevin B. Einkauf, Guinevere Q. Lee, Ce Gao, Radwa Sharaf, Xiaoming Sun, S. Hua, Samantha M. Y. Chen, Chenyan Jiang, Xiaodong Lian, Fatema Z. Chowdhury, E. Rosenberg, T. Chun, Jonathan Z. Li, Xu G. Yu, M. Lichterfeld   +14 more
semanticscholar   +1 more source

Single-cell TCR sequencing reveals phenotypically diverse clonally expanded cells harboring inducible HIV proviruses during ART

Nature Communications, 2020
Clonal expansions occur in the persistent HIV reservoir as shown by the duplication of proviral integration sites. However, the source of the proliferation of HIV-infected cells remains unclear.
P. Gantner, A. Pagliuzza, Marion Pardons, M. Ramgopal, J. Routy, R. Fromentin, N. Chomont   +6 more
semanticscholar   +1 more source

Cellular Activation, Differentiation, and Proliferation Influence the Dynamics of Genetically Intact Proviruses Over Time

Journal of Infectious Diseases, 2021
Human immunodeficiency virus (HIV) persists in cells despite antiretroviral therapy; however, the influence of cellular mechanisms such as activation, differentiation, and proliferation upon the distribution of proviruses over time is unclear. To address
B. Horsburgh, B. Hiener, K. Fisher, Eunok Lee, Hannah Morgan, John-Sebastian Eden, S. von Stockenstrom, L. Odevall, J. Milush, R. Hoh, R. Fromentin, N. Chomont, F. Hecht, T. Schlub, S. Deeks, S. Palmer   +15 more
semanticscholar   +1 more source

Screening and Identification of Human Endogenous Retrovirus-K mRNAs for Breast Cancer Through Integrative Analysis of Multiple Datasets

Frontiers in Oncology, 2022
ObjectiveHuman endogenous retroviruses (HERVs) make up 8% of the human genome. HERVs are biologically active elements related to multiple diseases.
Yongzhong Wei, Huilin Wei, Yinfeng Wei, Aihua Tan, Xiuyong Chen, Xiuquan Liao, Bo Xie, Xihua Wei, Lanxiang Li, Zengjing Liu, Shengkang Dai, Adil Khan, Xianwu Pang, Nada M. A. Hassan, Kai Xiong, Kai Zhang, Jing Leng, Jiannan Lv, Yanling Hu, Yanling Hu   +19 more
doaj   +1 more source

Expression of alternatively spliced human T-cell leukemia virus type 1 mRNAs is influenced by mitosis and by a novel cis-acting regulatory sequence [PDF]

, 2016
Human T-cell leukemia virus type 1 (HTLV-1) expression depends on the concerted action of Tax, which drives transcription of the viral genome, and Rex, which favors expression of incompletely spliced mRNAs and determines a 2-phase temporal pattern of ...
Bona, Marion K., Cavallari, Ilaria, Ciminale, Vincenzo, D'Agostino, DONNA MIA, Franchini, Genoveffa, Legrice, Stuart F. J., Rende, Francesca, SILIC-BENUSSI, Micol, Sztuba Solinska, Joanna, Tognon, Martina   +9 more
core   +1 more source

Co-option of an endogenous retrovirus envelope for host defense in hominid ancestors [PDF]

, 2017
Endogenous retroviral sequences provide a molecular fossil record of ancient infections whose analysis might illuminate mechanisms of viral extinction.
Bieniasz, Paul D., Blanco-Melo, Daniel, Gifford, Robert J.   +2 more
core   +2 more sources

Selection of epigenetically privileged HIV-1 proviruses during treatment with panobinostat and interferon-α2a

Cell
Summary CD4+ T cells with latent HIV-1 infection persist despite treatment with antiretroviral agents and represent the main barrier to a cure of HIV-1 infection.
Marie Armani-Tourret, Ce Gao, C. Hartana, Weiwei Sun, Leah Carrere, Liliana Vela, Alexander S Hochroth, Maxime Bellefroid, Amy Sbrolla, Katrina Shea, T. Flynn, Isabelle Roseto, Yelizaveta Rassadkina, Carole Lee, Francoise F. Giguel, Rajeev Malhotra, Frederic D. Bushman, Rajesh T. Gandhi, Xu G Yu, D. R. Kuritzkes, M. Lichterfeld   +20 more
semanticscholar   +1 more source

People Living With HIV Have More Intact HIV DNA in Circulating CD4+ T Cells if They Have History of Pulmonary Tuberculosis

Pathogens and Immunity
Background: A primary barrier to curing HIV is the HIV reservoir. The leading infectious cause of death worldwide for people living with HIV is tuberculosis (TB), but we do not know how TB impacts the HIV reservoir.
Marc Antoine Jean Juste, Yvetot Joseph, Dominique Lespinasse, Alexandra Apollon, Parmida Jamshidi, Myung Hee Lee, Maureen Ward, Esther Brill, Yanique Duffus, Uche Chukwukere, Ali Danesh, Winiffer Alberto, Daniel Fitzgerald, Jean Pape, R Jones, Kathryn Dupnik   +15 more
doaj   +1 more source