Results 71 to 80 of about 18,625 (239)

Digital PCR as a tool to measure HIV persistence [PDF]

, 2018
Although antiretroviral therapy is able to suppress HIV replication in infected patients, the virus persists and rebounds when treatment is stopped.
Bosman, Kobus, Nijhuis, Monique, Rutsaert, Sofie, Trypsteen, Wim, Vandekerckhove, Linos   +4 more
core   +1 more source

Improved Detection of HIV Gag p24 Protein Using a Combined Immunoprecipitation and Digital ELISA Method

Frontiers in Microbiology, 2021
Greater than 90% of HIV-1 proviruses are thought to be defective and incapable of viral replication. While replication competent proviruses are of primary concern with respect to disease progression or transmission, studies have shown that even defective
Guoxin Wu, Carol Cheney, Qian Huang, Daria J. Hazuda, Bonnie J. Howell, Paul Zuck   +5 more
doaj   +1 more source

Sequence Instability in the Proviral Long Terminal Repeat and gag Regions from Peripheral Blood and Tissue-Derived Leukocytes of FIV-Infected Cats during the Late Asymptomatic Phase. [PDF]

, 2016
Feline immunodeficiency virus (FIV) infection results in viral persistence, a prolonged asymptomatic phase, and progressive immunopathology. During the asymptomatic phase, a cohort of experimentally FIV-infected cats exhibits features of viral latency in
Eckstrand, Christina D, Hillman, Chadwick, Murphy, Brian G   +2 more
core   +3 more sources

HIV Infected T Cells Can Proliferate in vivo Without Inducing Expression of the Integrated Provirus

Frontiers in Microbiology, 2019
BackgroundHIV-1 proviruses can persist during ART in clonally-expanded populations of CD4+ T cells. To date, few examples of an expanded clones containing replication-competent proviruses exist, although it is suspected to be common.
Andrew Musick, Jonathan Spindler, Eli Boritz, Liliana Pérez, Daniel Crespo-Vélez, Sean C. Patro, Michele D. Sobolewski, Michael J. Bale, Carolyn Reid, Brandon F. Keele, Adam Capoferri, Wei Shao, Ann Wiegand, Francesco R. Simonetti, John W. Mellors, Stephen H. Hughes, John M. Coffin, Frank Maldarelli, Mary F. Kearney   +18 more
doaj   +1 more source

T cell stimulation remodels the latently HIV-1 infected cell population by differential activation of proviral chromatin.

PLoS Pathogens, 2022
The reservoir of latently HIV-1 infected cells is heterogeneous. To achieve an HIV-1 cure, the reservoir of activatable proviruses must be eliminated while permanently silenced proviruses may be tolerated.
Birgitta Lindqvist, Bianca B Jütte, Luca Love, Wlaa Assi, Julie Roux, Anders Sönnerborg, Tugsan Tezil, Eric Verdin, J Peter Svensson   +8 more
doaj   +1 more source

Aging-associated patterns in the expression of human endogenous retroviruses.

PLoS ONE, 2018
Human endogenous retroviruses (HERV) are relics of ancient retroviral infections in our genome. Most of them have lost their coding capacity, but proviral RNA or protein have been observed in several disease states (e.g.
Tapio Nevalainen, Arttu Autio, Binisha Hamal Mishra, Saara Marttila, Marja Jylhä, Mikko Hurme   +5 more
doaj   +1 more source

Early and Highly Suppressive ART are Main Factors Associated with Low Viral Reservoir in European Perinatally HIV Infected Children [PDF]

, 2018
BACKGROUND: Future strategies aiming to achieve HIV-1 remission are likely to target individuals with small reservoir size. SETTING: We retrospectively investigated factors associated with HIV-1 DNA levels in European, perinatally HIV-infected ...
Babiker, Abdel, Chan, Man, Cotugno, Nicola, De Rossi, Anita, Epiical, Consortium, Ferns, Bridget, Fortuny, Claudia, Foster, Caroline, Freguja, Riccardo, Giaquinto, Carlo, Gibb, Diana, Judd, Ali, Klein, Nigel, Mellado, Mar\ueda Jos\ue9, Mu\uf1oz-Fern\ue1ndez, Mar\ueda Angeles, Nastouli, Eleni, Navarro, Mar\ueda Luisa, Noguera-Julian, Antoni, Palma, Paolo, Rojo, Pablo, Rossi, Paolo, Tagarro, Alfredo, Zangari, Paola   +22 more
core   +2 more sources

Structural rearrangements in the nucleus localize latent HIV proviruses to a perinucleolar compartment supportive of reactivation

Proceedings of the National Academy of Sciences of the United States of America
Significance Persistent viral reservoirs in memory T cells harbor latent replication-competent proviruses that can rebound after interruption of antiretroviral therapy.
F. Kizito, Kien Nguyen, Uri Mbonye, Meenakshi Shukla, B. Luttge, M. Checkley, Anna Agaponova, K. Leskov, Jonathan Karn   +8 more
semanticscholar   +1 more source

Variant splicing and influence of ionizing radiation on human endogenous retrovirus K (HERV-K) transcripts in cancer cell lines. [PDF]

PLoS ONE, 2013
Human endogenous retrovirus K (HERV-K) is the most intact retrovirus in the human genome. There are multiple full-length or near full-length HERV-K proviruses in it.
Lorenzo Agoni, Jack Lenz, Chandan Guha
doaj   +1 more source

Integration in oncogenes plays only a minor role in determining the in vivo distribution of HIV integration sites before or during suppressive antiretroviral therapy.

PLoS Pathogens, 2021
HIV persists during antiretroviral therapy (ART) as integrated proviruses in cells descended from a small fraction of the CD4+ T cells infected prior to the initiation of ART.
John M Coffin, Michael J Bale, Daria Wells, Shuang Guo, Brian Luke, Jennifer M Zerbato, Michele D Sobolewski, Twan Sia, Wei Shao, Xiaolin Wu, Frank Maldarelli, Mary F Kearney, John W Mellors, Stephen H Hughes   +13 more
doaj   +1 more source