Results 81 to 90 of about 18,625 (239)

Heterogeneity in HIV and cellular transcription profiles in cell line models of latent and productive infection: implications for HIV latency. [PDF]

, 2019
BackgroundHIV-infected cell lines are widely used to study latent HIV infection, which is considered the main barrier to HIV cure. We hypothesized that these cell lines differ from each other and from cells from HIV-infected individuals in the mechanisms
Aran, Dvir, Butte, Atul J, Greene, Warner C, Hsieh, Christine, Joshi, Sunil, Kim, Peggy, Montano, Mauricio, Morón-López, Sara, Telwatte, Sushama, Wong, Joseph K, Yukl, Steven A   +10 more
core   +1 more source

Update on Non‐Biological and RNA‐Based Therapeutics in Chronic Inflammatory Diseases: Precision Medicine Through Small Molecules: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter, I. M. Adcock, C. Benito‐Villalvilla, R. Bianchini, L. Bjermer, G. Caramori, L. Cari, K. F. Chung, Z. Diamant, I. Eguiluz‐Gracia, E. F. Knol, M. Jesenak, F. Levi‐Schaffer, G. Nocentini, L. O'Mahony, O. Palomares, F. Redegeld, M. Sokolowska, B. Van Esch, M. Zurlo, C. Stellato   +20 more
wiley   +1 more source

The HIV-2 proviral landscape is dominated by defective proviruses

AIDS, 2023
Background: Compared with HIV-1 infection, HIV-2 infection is associated with a slower progression to AIDS. Understanding the persistence of HIV-2 infection might inform the mechanisms responsible for differences in the pathogenicity of HIV-2 versus HIV-1. Methods: In this study, we
Koofhethile, Catherine K., Gao, Ce, Chang, Charlotte, Lian, Xiaodong, Shapiro, Roger, Yu, Xu G., Lichterfeld, Mathias, Kanki, Phyllis J.   +7 more
openaire   +2 more sources

Differential Expression of HERV-K (HML-2) Proviruses in Cells and Virions of the Teratocarcinoma Cell Line Tera-1

Viruses, 2015
Human endogenous retrovirus (HERV-K (HML-2)) proviruses are among the few endogenous retroviral elements in the human genome that retain coding sequence.
Neeru Bhardwaj, Meagan Montesion, Farrah Roy, John M. Coffin   +3 more
doaj   +1 more source

NanoHIV: A Bioinformatics Pipeline for Producing Accurate, Near Full-Length HIV Proviral Genomes Sequenced Using the Oxford Nanopore Technology

Cells, 2021
HIV-1 proviral single-genome sequencing by limiting-dilution polymerase chain reaction (PCR) amplification is important for differentiating the sequence-intact from defective proviruses that persist during antiretroviral therapy (ART).
Imogen A. Wright, Kayla E. Delaney, Mary Grace K. Katusiime, Johannes C. Botha, Susan Engelbrecht, Mary F. Kearney, Gert U. van Zyl   +6 more
doaj   +1 more source

A quantitative approach for measuring the reservoir of latent HIV-1 proviruses. [PDF]

, 2019
A stable latent reservoir for HIV-1 in resting CD4+ T cells is the principal barrier to a cure1-3. Curative strategies that target the reservoir are being tested4,5 and require accurate, scalable reservoir assays.
Antar, Annukka AR, Beg, Subul A, Bender, Alexandra M, Bertagnolli, Lynn N, Blankson, Joel N, Bruner, Katherine M, Bushman, Frederic D, Capoferri, Adam A, Deeks, Steven G, Fray, Emily J, Gregg, John, Ho, Ya-Chi, Jenike, Katharine M, Kufera, Joshua T, Kwon, Kyungyoon J, Laird, Gregory M, Margolick, Joseph B, Nobles, Christopher, Sengupta, Srona, Siliciano, Janet D, Siliciano, Robert F, Simonetti, Francesco R, Timmons, Andrew, Wada, Nikolas, Wang, Zheng, Zhang, Hao   +25 more
core   +1 more source

Population dynamics of rhesus macaques and associated foamy virus in Bangladesh. [PDF]

, 2013
Foamy viruses are complex retroviruses that have been shown to be transmitted from nonhuman primates to humans. In Bangladesh, infection with simian foamy virus (SFV) is ubiquitous among rhesus macaques, which come into contact with humans in diverse ...
Andreina Pacheco, M, Barry, Peter A, Craig, Karen L, Engel, Gregory A, Escalante, Ananias A, Feeroz, Mostafa M, Jackson, Dana L, Jones-Engel, Lisa, Kamrul Hasan, M, Lee, Eun-Gyung, Lerche, Nicholas W, Levine, Kathryn L, Linial, Maxine L, Matsen Iv, Frederick A, Oh, Gunwha, Rabiul Alam, SM, Small, Christopher T, Soliven, Khanh, Wang, Xiaoxing, Yee, JoAnn L   +19 more
core   +1 more source

Immune non‐response despite effective antiretroviral therapy in people living with HIV: A review of potential mechanisms, biomarkers and therapeutic approaches

HIV Medicine, EarlyView.
Abstract Introduction A proportion of people living with HIV (PLWH) fail to restore their CD4 count or their CD4/CD8 ratio despite effective antiretroviral therapy (ART). PLWH with immune non‐response (INR) are at a higher risk of both AIDS and non‐AIDS events. The underlying mechanisms of INR remain unclear.
Charlotte Silvestre, Antoine Gross, Alain Makinson   +2 more
wiley   +1 more source

Mapping of alterations in noninfectious proviruses of spleen necrosis virus [PDF]

Journal of Virology, 1981
Ten recombinant lambda phage containing proviruses of spleen necrosis virus (SNV) were previously obtained. Six of the proviruses are infectious and four are not infectious in infectious DNA assays. In this paper, we show that these noninfectious proviruses are not infectious because of alterations in the viral DNA.
J J, O'Rear, H M, Temin
openaire   +2 more sources

Silencing of Unintegrated Retroviral DNAs

Viruses, 2021
Retroviral infection delivers an RNA genome into the cytoplasm that serves as the template for the synthesis of a linear double-stranded DNA copy by the viral reverse transcriptase.
Stephen P. Goff
doaj   +1 more source