Results 81 to 90 of about 13,226 (233)

Proviruses with identical sequences comprise a large fraction of the replication-competent HIV reservoir

PLoS Pathogens, 2017
The major obstacle to curing HIV infection is the persistence of cells with intact proviruses that can produce replication-competent virus. This HIV reservoir is believed to exist primarily in CD4+ T-cells and is stable despite years of suppressive ...
John K Bui, M. Sobolewski, B. Keele, J. Spindler, Andrew Musick, A. Wiegand, B. Luke, W. Shao, S. Hughes, J. Coffin, Mary F. Kearney, J. Mellors   +11 more
semanticscholar   +1 more source

Diagnostic utility and pitfalls of human T‐lymphotropic virus serology in adult T‐cell leukemia/lymphoma: evidence from a 25‐year pathology‐based nonendemic cohort

The Journal of Pathology: Clinical Research, Volume 12, Issue 1, January 2026.
Abstract Adult T‐cell leukemia/lymphoma (ATLL) is a distinct type of peripheral T‐cell lymphoma (PTCL) driven by human T‐lymphotropic virus type I (HTLV‐1)–infected T cells, but diagnosis can be confounded by histological overlap with non‐ATLL PTCL. While molecular testing is the diagnostic gold standard in endemic areas, HTLV‐1/2 serology is often ...
Chang‐Tsu Yuan, Li‐Yu Sun, Shih‐Sung Chuang, Kennosuke Karube, Hsiao‐Bai Yang, Sze‐Hwei Lee, Ren‐Ching Wang, Kung‐Chao Chang, Chein‐Jun Kao, Huai‐Hsuan Huang, Wen‐Chien Chou   +10 more
wiley   +1 more source

Similar frequency and inducibility of intact HIV-1 proviruses in blood and lymph nodes.

Journal of Infectious Diseases, 2020
BACKGROUND The HIV-1 latent reservoir (LR) in resting CD4 + T cells is a barrier to cure. LR measurements are commonly performed on blood samples and therefore may miss latently infected cells residing in tissues, including lymph nodes.
Alyssa R. Martin, A. Bender, J. Hackman, K. J. Kwon, B. Lynch, D. Bruno, C. Martens, Subul A. Beg, S. Florman, N. Desai, D. Segev, G. Laird, J. Siliciano, T. Quinn, A. Tobian, C. Durand, R. Siliciano, A. Redd   +17 more
semanticscholar   +1 more source

HERV‐K TM Subunit Elicits CD8+ T Cell Anergy and Tumor Immune Evasion via Targeting CD3 Coreceptor ε in AML and PDAC

Advanced Science, Volume 13, Issue 1, 5 January 2026.
Novel viral immune checkpoint K‐TM subunit is aberrantly expressed in CD8+ T cells and enriched in sera of cancer patients, inducing CD8+ T cell anergy and eliciting potent tumor immune escape in mouse model. Mechanistically, K‐TM directly targets and induces the phosphorylation of CD3ε receptor.
Mengyuan Li, Shuwen Zheng, Qinyuan Gong, Zhaoxing Wu, Wen Lei, Wanyue Cao, Ping Wang, Xuzhao Zhang, Wenbin Qian, Yun Liang, Ying Lu, Fenglin Li, Qi Zhang, Rongzhen Xu   +13 more
wiley   +1 more source

Experimentally introduced defective endogenous proviruses are highly expressed in chickens [PDF]

Journal of Virology, 1991
We have previously described the experimental introduction of recombinant subgroup A avian leukosis viruses (ALV) with Rous-associated virus 0 long terminal repeats into the germ line of line 0 chickens and the generation of 23 transgenic lines. Two of these transgenic lines, alv6 and alv11, do not produce infectious virus.
M J, Federspiel, L B, Crittenden, L P, Provencher, S H, Hughes   +3 more
openaire   +2 more sources

G-Quadruplex DNA and Other Non-Canonical B-Form DNA Motifs Influence Productive and Latent HIV-1 Integration and Reactivation Potential

Viruses, 2022
The integration of the HIV-1 genome into the host genome is an essential step in the life cycle of the virus and it plays a critical role in the expression, long-term persistence, and reactivation of HIV expression. To better understand the local genomic
Hannah O. Ajoge, Hinissan P. Kohio, Ermela Paparisto, Macon D. Coleman, Kemen Wong, Sean K. Tom, Katie L. Bain, Charles C. Berry, Eric J. Arts, Stephen D. Barr   +9 more
doaj   +1 more source

Diversity and Ecological Potentials of Marine Viruses Inhabiting Continental Shelf Seas

Advanced Science, Volume 13, Issue 1, 5 January 2026.
To the best of the knowledge, this study provides the largest viral genome dataset from a continental shelf sea. It reveals that over half of vOTUs are novel, highlighting the remarkable viral novelty in the eastern continental shelf seas of China (ECSSC).
Xiaoyue Guo, Yantao Liang, Chen Gao, Hao Yu, Meiwen Wang, Hongbing Shao, Yeqing Yang, David Paez‐Espino, Andrew McMinn, Min Wang   +9 more
wiley   +1 more source

Characterization, Mapping, and Distribution of the Two XMRV Parental Proviruses [PDF]

Journal of Virology, 2012
ABSTRACT Xenotropic murine leukemia virus-related virus (XMRV) was previously reported to be associated with human prostate cancer and chronic fatigue syndrome. Our groups recently showed that XMRV was created through recombination between two endogenous murine retroviruses, PreXMRV-1 and PreXMRV-2, during the passaging of a ...
Oya, Cingöz, Tobias, Paprotka, Krista A, Delviks-Frankenberry, Sheryl, Wildt, Wei-Shau, Hu, Vinay K, Pathak, John M, Coffin   +6 more
openaire   +2 more sources

CXCR3/CXCL10 Axis‐Mediated T Cell Infiltration in the Lungs of Patients With HTLV‐1‐Associated Diseases: Implications for Subclinical Pulmonary Involvement

Journal of Medical Virology, Volume 98, Issue 1, January 2026.
Abstract HTLV‐1 is a retrovirus associated with adult T cell leukemia/lymphoma (ATL) and inflammatory diseases, including HTLV‐1‐associated myelopathy (HAM) and HTLV‐1‐associated bronchopneumonopathy (HAB). Although pulmonary complications are common in HTLV‐1‐associated diseases, the underlying mechanisms remain unclear.
Kanako Tsuchimoto, Ayasa Mori, Masakazu Tanaka, Shiho Arishima, Daisuke Kodama, Mika Dozono, Satoshi Nozuma, Hiroshi Takashima, Ryuji Kubota   +8 more
wiley   +1 more source

Genomic Validation of PERV‐C‐Free Pigs to Support Xenotransplantation

Xenotransplantation, Volume 33, Issue 1, January/February 2026.
ABSTRACT Porcine endogenous retroviruses (PERVs) are present in the germ lines of domesticated pigs (Sus scrofa) and related suids. There are three types of PERVs, PERV‐A, ‐B, and ‐C, which differ in their host range. PERV‐A and ‐B can infect human and porcine cells, while PERV‐C only infects porcine cells. PERV‐A and ‐B are found in the genomes of all
Neal R. Benjamin, Giovanni Madrigal, Yasuko Ishida, Julian Catchen, Kari L. Allen, Brent Pepin, Alfred L. Roca   +6 more
wiley   +1 more source