Results 111 to 120 of about 53,118 (291)

Case Report: Abemaciclib‐Induced Chronic Renal Failure

open access: yesMedicine Advances, EarlyView.
This article reports a case of chronic kidney injury caused by Abemaciclib, which suggests that long‐term use of Abemaciclib may lead to kidney damage, potentially progressing to chronic renal failure. It is essential to regularly monitor kidney function indicators before and after treatment.
Lu Lin   +4 more
wiley   +1 more source

Nephroprotective Effects of Fraxinus Hookeri Wenz. Against Renal Toxicity and DNA Oxidative Damages Induced by CCl4 in Rats

open access: yesChemistryOpen, EarlyView.
This study evaluates the nephroprotective potential of Fraxinus hookeri Wenz. (F. hookeri), a medicinal plant of the Oleaceae family, against CCl4‐induced oxidative stress. The findings demonstrate its ability to restore antioxidant defenses, renal function markers, and DNA integrity while reducing lipid peroxidation and histopathological damage.
Raheela Sarwar   +9 more
wiley   +1 more source

Tissue‐Specific Regulation of Fatty Acid Metabolism in a Mouse Model of Isolated Complex I Deficiency

open access: yesPROTEOMICS, EarlyView.
ABSTRACT Isolated complex I deficiency (ICD) is commonly associated with mitochondrial diseases and closely mimics subacute necrotising encephalomyelopathy. This disorder is characterised by metabolic perturbations that affect energy metabolism pathways, including fatty acid metabolism.
Sibonelo Glen Khumalo   +2 more
wiley   +1 more source

Effect of green tea extract (Camellia sinensis) on kidney toxicity induced by sodium arsenite: a stereological study

open access: yesمجله دانشگاه علوم پزشکی گرگان, 2016
Background and Objective: Sodium Arsenite is an environmental pollutant which can generate free radicals causing tissue damage. This study was done to evaluate the effect of Green Tea (GTE), as a strong antioxidant, on kidney tissue in mice treated with ...
Shariatzadeh SMA   +3 more
doaj  

Urinary Proteomics and Systems Biology Link Eight Proteins to the Higher Risk of Hypertension and Related Complications in Blacks Versus Whites

open access: yesPROTEOMICS, EarlyView.
ABSTRACT Blacks are more prone to salt‐sensitive hypertension than Whites. This cross‐sectional analysis of a multi‐ethnic cohort aimed to search for proteins potentially involved in the susceptibility to salt sensitivity, hypertension, and hypertension‐related complications.
De‐Wei An   +22 more
wiley   +1 more source

Controlling Drug Release From Supramolecular Polymer Surfaces by a Click‐To‐Release Reaction

open access: yesJournal of Polymer Science, EarlyView.
We present a strategy combining reactive supramolecular additives with a covalent click‐to‐release reaction for localized drug delivery. A trans‐cyclooctene additive releases a cytotoxic drug upon tetrazine administration. Fluorescent monitoring confirms release, and cytotoxic tests show effective cancer cell death.
Maritza M. Rovers   +6 more
wiley   +1 more source

Deep learning (DL)‐based advancements in prostate cancer imaging: Artificial intelligence (AI)‐based segmentation of 68Ga‐PSMSA PET for tumor volume assessment

open access: yesPrecision Radiation Oncology, EarlyView.
This review highlights the use of 68Ga‐PSMA PET in prostate cancer (PC) for tumor volume quantification, crucial for staging, treatment planning, and prognosis. Traditional manual segmentation methods are time‐consuming and variable, while AI‐based segmentation techniques, particularly deep learning models like convolutional neural networks, offer ...
Sharjeel Usmani   +6 more
wiley   +1 more source

Acute kidney injury and iron metabolism: A narrative review focusing on pathophysiology and therapy

open access: yesSmart Molecules, EarlyView.
Schematic illustration of acute kidney injury and iron metabolism (By Figdraw). Image for iron metabolism, including uptake, storage, utilization, export: Reproduced with permission. Abstract Acute kidney injury (AKI) represents a substantial challenge to public health and is characterized by elevated occurrence and fatality rates.
Xinyu Tan   +4 more
wiley   +1 more source

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