Results 131 to 140 of about 684,958 (347)
Complex interactions between cis-regulatory modules in native conformation are critical for Drosophila snail expression [PDF]
, 2011 It has been shown in several organisms that multiple cis-regulatory modules (CRMs) of a gene locus can be active concurrently to support similar spatiotemporal expression.
Dunipace, Leslie +2 more
core +3 more sources
British Journal of Clinical Pharmacology, EarlyView.SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić +7 more
wiley +1 more source
PLoS ONE, 2013 Autosomal dominant polycystic kidney disease (ADPKD) is associated with a variety of cellular phenotypes in renal epithelial cells. Cystic epithelia are secretory as opposed to absorptive, have higher proliferation rates in cell culture and have some ...
Brittney-Shea Herbert +13 more
doaj +1 more source
Anion transporter: highly cell-type-specific expression of distinct polypeptides and transcripts in erythroid and nonerythroid cells [PDF]
, 1985 Affinity-purified antibodies and cDNA probes specific for the chicken erythrocyte anion transporter (also referred to as band 3) have been used to demonstrate that this protein is expressed in a highly cell- type-specific manner in the avian kidney ...
Cox, John V. +2 more
core +1 more source
Determinants of the effect of furosemide on the proximal tubule
Kidney International, 1972 Determinants of the effect of furosemide on the proximal tubule.The recollection renal micropuncture technique was used to assess fractional and, on occasion, absolute volume reabsorption in the dog late proximal tubule before and during a furosemide diuresis in which urine losses were or were not replaced.Similar observations were made before and ...
Burke, Thomas J. +2 more
openaire +2 more sources
Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics
British Journal of Clinical Pharmacology, EarlyView.Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay +5 more
wiley +1 more source
Comparative Physiology of the Renal Proximal Tubule
Kidney and Blood Pressure Research, 1985 The comparative physiology of the renal proximal tubule (PT) is reviewed in the context of vertebrate evolution and vertebrate strategies of salt and water balance. Though extrarenal machanisms of salt and water balance contribute importantly to extracellular fluid (ECF) homeostasis in the lower vertebrates, the kidney acquires these functions with ...
openaire +2 more sources
Possible therapeutic repositioning of valproic acid: From epileptic seizures to acute kidney injury
British Journal of Clinical Pharmacology, EarlyView.Valproic acid, an anticonvulsant, may be repositioned to prevent acute kidney injury due to ischemia followed by reperfusion. It preserves renal functions, electrolyte homeostasis and active sodium transport in kidney tubules, and blocks the onset of hypertension.
Danilo Alves‐Bezerra +8 more
wiley +1 more source
British Journal of Clinical Pharmacology, EarlyView.Abstract Aim The quantitative effect of several inhibitory drugs on the development of adverse drug reactions (ADRs) is currently difficult to estimate. Our aim was to identify metabolic pathways, which, when inhibited, increase the risk for certain ADRs, and to use this system to consider comedication at individual level. Methods Data of a prospective
Judith Berres +8 more
wiley +1 more source
Potassium channels in renal proximal tubule [PDF]
Medicinski Podmladak, 2017 Potassium channels are a diverse family of membrane proteins which are present within all cells of the body. They contain two subunits α, which determine the structure of the channel, and β, which can modify the properties of the channel.
Kovačević Sanjin +1 more
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