Results 121 to 130 of about 611,505 (395)

The role of renal transporters and novel regulatory interactions in the TAL that control blood pressure [PDF]

, 2017
Hypertension (HTN), a major public health issue is currently the leading factor in the global burden of disease, where associated complications account for 9.4 million deaths worldwide every year (98).
Dominiczak, Anna, Ferreri, Nicholas R., Graham, Lesley A.   +2 more
core   +1 more source

Beyond right or wrong: How partial credit scoring on multiple‐choice questions improves student performance and assessment perceptions

British Journal of Clinical Pharmacology, EarlyView.
Aims In this study, we examined the effects of assigning partial credit to selected answer choices on student performance and perceptions in a pharmacology course using Type A multiple‐choice questions (MCQs). Methods Partial credit scoring was incorporated into quizzes and exams in a 10‐week pharmacology course for postbaccalaureate premedical ...
Stephen D. Schneid, Chris Armour, Katharina Brandl   +2 more
wiley   +1 more source

Controlling nephron precursor differentiation to generate proximal-biased kidney organoids with emerging maturity

Nature Communications
The kidney maintains fluid homeostasis by reabsorbing essential compounds and excreting waste. Proximal tubule cells, crucial for reabsorbing sugars, ions, and amino acids, are highly susceptible to injury, often leading to pathologies necessitating ...
Jack Schnell, Zhen Miao, MaryAnne Achieng, Connor C. Fausto, Kari Koppitch, Lola Takhirov, Victoria Wang, Faith De Kuyper, Biao Huang, Megan Schreiber, Pedro Medina, Matthew E. Thornton, Brendan Grubbs, Zhongwei Li, Junhyong Kim, Nils O. Lindström   +15 more
doaj   +1 more source

Renal proximal tubule cells: power and finesse

The Journal of Clinical Investigation, 2023
The proximal tubule is the high-capacity reabsorptive powerhouse of the kidney. Two papers in recent issues of the JCI highlight mechanisms of more delicate effects of the proximal tubule. Yoon et al.
Michaela A.A. Fuchs, Myles Wolf
doaj   +1 more source

Acute effect of prednisolone on renal handling of sodium. [PDF]

, 1973
The effect of prednisolone on renal handling of sodium (Na) was studied in rats under three experimental conditions: 1) hydropenia, 2) water diuresis, and 3) distal tubular blockade (DTB).
Halgrimson, CG, Popovtzer, MM, Robinette, J, Starzl, TE   +3 more
core   +1 more source

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source

Very high water permeability in vasopressin-induced endocytic vesicles from toad urinary bladder. [PDF]

, 1989
The regulation of transepithelial water permeability in toad urinary bladder is believed to involve a cycling of endocytic vesicles containing water transporters between an intracellular compartment and the cell luminal membrane.
Shi, LB, Verkman, AS
core  

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

Stem cells derived from neonatal mouse kidney generate functional proximal tubule-like cells and integrate into developing nephrons in vitro.

PLoS ONE, 2013
We have recently shown that kidney-derived stem cells (KSCs) isolated from the mouse newborn kidney differentiate into a range of kidney-specific cell types.
Egon Ranghini, Cristina Fuente Mora, David Edgar, Simon E Kenny, Patricia Murray, Bettina Wilm   +5 more
doaj   +1 more source

Colocalization of GLUT2 glucose transporter, sodium/glucose cotransporter, and gamma-glutamyl transpeptidase in rat kidney with double-peroxidase immunocytochemistry. [PDF]

, 1992
Glucose is reabsorbed from the glomerular filtrate in the proximal segment of the renal tubule in two stages. The first stage is uphill transport across the brush border membrane by Na(+)-glucose cotransport and the second stage is downhill transport ...
Cramer, SC, Hirayama, BA, Pardridge, WM, Wright, EM   +3 more
core   +1 more source