Results 141 to 150 of about 611,505 (395)

Meta‐analysis of sotagliflozin, a dual sodium‐glucose‐cotransporter 1/2 inhibitor, for heart failure in type 2 diabetes

ESC Heart Failure, Volume 12, Issue 2, Page 968-979, April 2025.
Abstract Sodium‐glucose co‐transporters (SGLTs) mediate sodium and glucose transport across cell membranes. SGLT2 inhibitors have a recognized place within heart failure (HF) guidelines. We evaluated the effect of sotagliflozin on HF and cardiovascular outcomes in participants with type 2 diabetes. Scopus, Medline, Embase and Central were searched from
Maria Anna Bantounou, Panagiotis Sardellis, Josip Plascevic, Ribeya Awaes‐Mahmood, Justyna Kaczmarek, Daniel Black Boada, Rosa Thuemmler, Sam Philip   +7 more
wiley   +1 more source

Albumin Expands Albumin Reabsorption Capacity in Proximal Tubule Epithelial Cells through a Positive Feedback Loop between AKT and Megalin [PDF]

, 2022
Rodrigo P. Silva‐Aguiar, Diogo B. Peruchetti, Lucas S. Florentino, Christina Maeda Takiya, María‐Paz Marzolo, Wagner B. Dias, Ana Acácia S. Pinheiro, Celso Caruso‐Neves   +7 more
openalex   +1 more source

The effects of sodium–glucose cotransporter 2 inhibitors on the ‘forgotten’ right ventricle

ESC Heart Failure, Volume 12, Issue 2, Page 1045-1058, April 2025.
Abstract With the progress in diagnosis, treatment and imaging techniques, there is a growing recognition that impaired right ventricular (RV) function profoundly affects the prognosis of patients with heart failure (HF), irrespective of their left ventricular ejection fraction (LVEF).
Liangzhen Qu, Xueting Duan, Han Chen
wiley   +1 more source

Low potassium activation of proximal mTOR/AKT signaling is mediated by Kir4.2

Nature Communications
The renal epithelium is sensitive to changes in blood potassium (K+). We identify the basolateral K+ channel, Kir4.2, as a mediator of the proximal tubule response to K+ deficiency.
Yahua Zhang, Fabian Bock, Mohammed Ferdaus, Juan Pablo Arroyo, Kristie L Rose, Purvi Patel, Jerod S. Denton, Eric Delpire, Alan M. Weinstein, Ming-Zhi Zhang, Raymond C. Harris, Andrew S. Terker   +11 more
doaj   +1 more source

SARS-CoV-2 causes a specific dysfunction of the kidney proximal tubule

Kidney International, 2020
A. Werion, L. Belkhir, Marie Perrot, Gregory Schmit, S. Aydın, Zhiyong Chen, A. Penaloza, J. de Greef, H. Yildiz, L. Pothen, J. Yombi, J. Dewulf, A. Scohy, L. Gérard, X. Wittebole, P. Laterre, S. Miller, O. Devuyst, M. Jadoul, J. Morelle, Frank Souad Nadia Sarah Christophe Diego Emmanuel Christ Aboubakar Acid Amini Bailly Beauloye Castanares-Za, F. Aboubakar, S. Acid, Nadia Amini, S. Bailly, C. Beauloye, D. Castanares-Zapatero, E. Coche, C. Collienne, P. Cornette, Isabelle De Brauwer, M. Dechamps, F. Dupriez, A. Froidure, Q. Garnir, B. Gerber, B. Ghaye, I. Gilard, S. Gohy, C. Grégoire, P. Hantson, L. Jacquet, B. Kabamba, S. Kautbally, N. Lanthier, Fatima Larbaoui, G. Liistro, F. Maes, V. Montiel, B. Mwenge, S. Pierard, C. Pilette, A. Pouleur, Amaury Sogorb, P. Starkel, H. Rodriguez‐Villalobos, M. Thoma, Olivier Van Caeneghem, D. Vancraeynest   +58 more
semanticscholar   +1 more source

VPS34-dependent control of apical membrane function of proximal tubule cells and nutrient recovery by the kidney

, 2022
Markus M. Rinschen, Jennifer L. Harder, Madalina E. Carter-Timofte, Luis Zanon Rodriguez, Carmen Mirabelli, Fatih Demir, Naziia Kurmasheva, Suresh Krishna Ramakrishnan, Madlen Kunke, Yifan Tan, A. Billing, Eileen Dahlke, Alexey Larionov, Wibke Bechtel‐Walz, Ute Aukschun, Marlen Grabbe, Rikke Nielsen, Erik Christensen, Matthias Kretzler, Tobias B. Huber, Christiane E. Wobus, David Olagnier, Gary Siuzdak, Florian Grahammer, Franziska Theilig   +24 more
openalex   +2 more sources

Metabolic abnormalities and reprogramming in cats with naturally occurring hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.
Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li, Max Homilius, Erin Achilles, Laura K. Massey, Victoria Convey, Åsa Ohlsson, Ingrid Ljungvall, Jens Häggström, Brittany Vester Boler, Pascal Steiner, Sharlene Day, Calum A. MacRae, Mark A. Oyama   +12 more
wiley   +1 more source

Dapagliflozin alleviates high‐fat‐induced obesity cardiomyopathy by inhibiting ferroptosis

ESC Heart Failure, Volume 12, Issue 2, Page 1358-1373, April 2025.
Abstract Aim: Dapagliflozin (Dapa) is a novel hypoglycaemic agent with multiple cardiovascular protective effects, and it is widely used in treatment of heart failure patients, but whether it can improve obese phenotype of heart failure and its mechanism is still unclear.
Di Chen, Jiahao Shi, Yue Wu, Lizhu Miao, Zilin Wang, Yixuan Wang, Siwei Xu, Yu Lou   +7 more
wiley   +1 more source

Etoposide Induces Necrosis Through p53-Mediated Antiapoptosis in Human Kidney Proximal Tubule Cells [PDF]

, 2015
Hyuk‐Kwon Kwon, Hyeon‐Jun Shin, Jae‐Hyeok Lee, Seol-Hee Park, Mincheol Kwon, Suresh Panneerselvam, Chan Gyu Lee, Sang Geon Kim, Jae Ho Kim, Sangdun Choi   +9 more
openalex   +1 more source

EGR1 Nuclear Condensates Promote Renal Cyst Development in Polycystic Kidney Disease

Exploration, EarlyView.
ABSTRACT Autosomal dominant polycystic kidney disease (ADPKD) is marked by aberrant cell proliferation driven by cAMP‐PKA and MAPK signaling pathways. EGR1, a transcription factor directly activated by the above two pathways, is critical in the over‐proliferation of tumor cells, which share similarities with cystic epithelial cells in ADPKD. This study
Chaoqun Ren, Zhaoxu Wu, Min Li, Yaqin Du, Hong Zhou, Yazhu Quan, Mengyao Xiong, Yiming Wang, Zhiwei Qiu, Shuai Zhu, Xiaowei Li, Jinzhao He, Cai Gao, Hui Cai, Tingting Li, Baoxue Yang   +15 more
wiley   +1 more source