Results 201 to 210 of about 93,932 (331)

SGLT2 Inhibition by Enavogliflozin Significantly Reduces Aβ Pathology and Restores Cognitive Function via Upregulation of Microglial AMPK Signaling in 5XFAD Mouse Model of Alzheimer's Disease

Aging Cell, EarlyView.
SGLT2 inhibition with Enavogliflozin significantly improves cognitive function and reduces Aβ pathology in the 5XFAD mouse model of Alzheimer's disease. Through AMPK activation, Enavogliflozin enhances microglial mitochondrial function and Aβ phagocytosis while reducing neuroinflammation.
Jihui Han, Jaehoon Song, Eun Sun Jung, Ji Won Choi, Hye Young Ji, Inhee Mook‐Jung   +5 more
wiley   +1 more source

Beyond SGLT2: proximal tubule transporters as potential drug targets for chronic kidney disease. [PDF]

Nephrol Dial Transplant
Wagner CA.
europepmc   +1 more source

Perfusion rate-dependence of transepithelial osmosis in isolated proximal convoluted tubules: Estimation of the hydraulic conductance

, 1978
Thomas E. Andreoli, James A. Schafer, Susan L. Troutman   +2 more
openalex   +1 more source

Influence of peritubular protein on solute absorption in the rabbit proximal tubule. A specific effect on NaCl transport. [PDF]

, 1981
Christine Berry, Martin G. Cogan
openalex   +1 more source

Luteinizing hormone receptor knockout mouse: What has it taught us?

Andrology, EarlyView.
Abstract Luteinizing hormone (LH), along with its agonist choriongonadotropin (hCG) in humans, is the key hormone responsible for the tropic regulation of the gonadal function. LH and hCG act through their cognate receptor, the luteinizing hormone/choriongonadotropin receptor (LHCGR; more appropriately LHR in rodents lacking CG), located in the testis ...
Ilpo T. Huhtaniemi
wiley   +1 more source

Proximal tubule-on-chip as a model for predicting cation transport and drug transporter dynamics. [PDF]

Sci Rep
Petit I, Faucher Q, Bernard JS, Giunchi P, Humeau A, Sauvage FL, Marquet P, Védrenne N, Di Meo F.   +8 more
europepmc   +1 more source

Lack of relationship of potential difference to fluid absorption in the proximal renal tubule

, 1975
Jean Cardinal, Michael D. Lutz, Maurice B. Burg, Jack Orloff   +3 more
openalex   +1 more source

Role of prostaglandins in proximal tubule sodium reabsorption: response to elevated renal interstitial hydrostatic pressure. [PDF]

, 1989
Y. Kinoshita, Franklyn G. Knox
openalex   +1 more source

Folding, misfolding, and regulation of intracellular traffic of G protein‐coupled receptors involved in the hypothalamic–pituitary–gonadal axis

Andrology, EarlyView.
Abstract Background G protein‐coupled receptors are a large and functionally diverse family of membrane receptors involved in a number of biological processes. Like other proteins, G protein‐coupled receptors need to be properly folded in order to traffic to the plasma membrane and interact with agonist.
Alfredo Ulloa‐Aguirre, Ross C. Anderson, Teresa Zariñán, Rubén Gutiérrez‐Sagal, Eduardo Jardón‐Valadez, Claire L. Newton   +5 more
wiley   +1 more source

GPX4 expression changes in proximal tubule cells highlight the role of ferroptosis in IgAN. [PDF]

Sci Rep
Qing J, Zhang L, Fan R, Zhi H, Li C, Li Y, Wu J, Han C, Li Y.   +8 more
europepmc   +1 more source