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Androgens stimulate proximal tubule transport
Gender Medicine, 2008Disrupting the enzyme cytochrome P4a14 in mice leads to hypertension, which is more severe in male than in female mice and appears to be due to androgen excess. Androgens are known to increase expression of angiotensinogen,but the effect of androgens on proximal tubule transport is unknown.These studies aimed to determine the effect of androgens on ...
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A mathematical model of proximal tubule absorption
The Journal of Membrane Biology, 1979A previous model of the mechanisms of flow through epithelia was modified and extended to include hydrostatic and osmotic pressures in the cells and in the peritubular capillaries. The differential equations for flow and concentration in each region of the proximal tubule were derived. The equations were solved numerically by a finite difference method.
R E, Huss, J L, Stephenson
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An equation for flow in the renal proximal tubule
Bulletin of Mathematical Biology, 1986Approximate equations for epithelial solute and water transport have been combined with the relations of mass conservation to yield a single differential equation representing volume flow along the proximal tubule. This flow equation is first order, quasilinear and may be integrated directly.
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A Heartwarming Role of the Proximal Tubules
Clinical Journal of the American Society of Nephrology, 2022Michael L. Granda, Bryan Kestenbaum
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Interactions of vitamin D and the proximal tubule
Pediatric Nephrology, 2015Severe vitamin D deficiency (reduction in serum 25(OH)D concentration) in infants and children can cause features of the Fanconi syndrome, including phosphaturia, glycosuria, aminoaciduria, and renal tubular acidosis. This indicates that vitamin D and its metabolites influence proximal tubule function.
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Dopamine receptors in the proximal tubule of the rabbit
American Journal of Physiology-Renal Physiology, 1984Our laboratory has characterized dopamine receptors in glomeruli and tubular homogenates. Since the heterogeneity of kidney homogenates limits the interpretation of these studies, the [3H]haloperidol binding site and adenylate cyclase sensitivity to dopamine were studied in the isolated proximal convoluted tubule and pars recta of the rabbit kidney ...
R A, Felder +3 more
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Model of albumin reabsorption in the proximal tubule
American Journal of Physiology-Renal Physiology, 2007Normally, the small amount of albumin which passes through the glomerular capillary wall is almost completely reabsorbed in the proximal tubule, via an endocytic mechanism, but the reabsorptive process can be overwhelmed if the filtered load of albumin is too large.
Matthew J, Lazzara, William M, Deen
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Water permeability and pathways in the proximal tubule
American Journal of Physiology-Renal Physiology, 1983The route of water transport in the proximal tubule could be either transjunctional or transcellular. A transjunctional route is supported by data showing high osmotic-to-diffusive water permeability ratios, the possible correlation of junctional leakiness to ions and nonelectrolytes with water permeability, and solvent drag of nonelectrolytes and ...
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Proximal tubule response in aldosterone escape
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 1989The response of the proximal tubule to chronic aldosterone administration (15 micrograms.kg-1.day-1) was evaluated in eight conscious female mongrel dogs. Temporal profiles between hemodynamic and hormonal changes and the fractional excretions of sodium and lithium were established.
J M, Gonzalez-Campoy +5 more
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Mechanisms of chloride transport in the proximal tubule
American Journal of Physiology-Renal Physiology, 1997The major fraction of filtered Cl- is reabsorbed in the proximal tubule. An important component of Cl- reabsorption is passive and paracellular, driven by the lumen-negative potential difference in the early proximal tubule and the outwardly directed concentration gradient for Cl- in the later proximal tubule.
P S, Aronson, G, Giebisch
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