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Endocytic Receptors in the Renal Proximal Tubule
Physiology, 2012Protein reabsorption is a predominant feature of the renal proximal tubule. Animal studies show that the ability to rescue plasma proteins relies on the endocytic receptors megalin and cubilin. Recently, studies of patients with syndromes caused by dysfunctional receptors have supported the importance of these for protein clearance of human ...
Christensen, Erik Ilsø +4 more
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Oxalate secretion in the rat proximal tubule
American Journal of Physiology-Renal Physiology, 1981Simultaneous capillary and luminal microperfusion studies in the proximal convoluted tubule of the rat were performed to examine the transepithelial secretory flux of [14C]oxalate. Increases in the concentration of oxalate in the capillary solution from 0.096 to 4.3 mM resulted in progressively higher rates of oxalate secretion into the lumen. Further
T F, Knight +3 more
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Ammonia Transport in the Proximal Tubule In Vivo
American Journal of Kidney Diseases, 1989Studies were performed to characterize the determinants of proximal tubule ammonia entry (and retention) in vivo. Rat proximal tubules were studied in vivo using in situ microperfusion. In both normal animals and animals with metabolic acidosis, increasing luminal flow rate significantly enhanced luminal ammonia entry.
L L, Hamm, E E, Simon
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Calcium Transport by the Proximal Tubule
1986Taken together the results of these in vivo microperfusion experiments indicate that calcium absorption by the proximal tubule depends on more than one transport mechanism. We have observed that net calcium flux is affected by changes in calcium ion activity (even with constant total calcium concentration) and in transepithelial voltage.
F S, Wright, K, Bomsztyk
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1994
The morphology of the proximal tubule cells was covered briefly in Chapter 2, but will be considered in more detail here. The proximal tubule is divisible into the convoluted portion, or pars convoluta, which begins immediately behind the glomerulus, and the straight portion, or pars recta, which passes into the medulla to become the loop of Henle. The
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The morphology of the proximal tubule cells was covered briefly in Chapter 2, but will be considered in more detail here. The proximal tubule is divisible into the convoluted portion, or pars convoluta, which begins immediately behind the glomerulus, and the straight portion, or pars recta, which passes into the medulla to become the loop of Henle. The
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Chloride Transport in the Proximal Renal Tubule
Annual Review of Physiology, 1988Our knowledge of chloride transport along the nephron has greatly expanded. Whereas for a long time it was assumed that chloride ions were reabsorbed entirely passively with sodium--the "mendicant" role of chloride, more recent studies suggest that several distinct reabsorptive transport mechanisms operate in parallel.
L, Schild, G, Giebisch, R, Green
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The Proximal Tubule and the Podocyte in Cystinosis
Nephron, 2008The belief that the swan-neck lesion or the Fanconi syndrome in cystinosis are related to the accumulation of cystine in epithelium of the proximal tubule is questioned. The vulnerability of the visceral glomerular epithelium in cystinosis is emphasized.
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Androgens augment proximal tubule transport
American Journal of Physiology-Renal Physiology, 2004The proximal tubule contains an autonomous renin-angiotensin system that regulates transport independently of circulating angiotensin II. Androgens are known to increase expression of angiotensinogen, but the effect of androgens on proximal tubule transport is unknown.
Albert, Quan +8 more
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Nephrotoxicity and the Proximal Tubule
Nephron Physiology, 2003Cadmium (Cd<sup>2+</sup>) is a non-essential heavy metal, which is taken up from the environment into the body through pulmonary and enteral pathways. The S1 segment of the kidney proximal tubule (PT) is a major target of chronic Cd<sup>2+</sup> toxicity.
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Water Permeability in Rat Proximal Tubules
Acta Physiologica Scandinavica, 1970AbstractThe diffusional water permeability in rat proximal tubules was studied in microperfusion experiments with triturated water. The perfusion solutions were chosen either to give no net flux or a net water flux in either direction. The diffusional water permeability at zero net water flux was 564. 10‐‐5 cm/sec.
E, Persson, H R, Ulfendahl
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