Results 201 to 210 of about 684,958 (347)

AntimiR uptake by human proximal tubule epithelial cells is predominantly by macropinocytosis. [PDF]

Sci Rep
Glover EK, Berlinguer-Palmini R, Thompson ER, Wilson C, Denby L, Reynolds G, Ali S, Lowe M, Lennon R, Sheerin NS.   +9 more
europepmc   +1 more source

Renal‐vascular axis: unmasking its role in vascular endothelial growth factor‐inhibitor vascular toxicity in cancer patients

British Journal of Pharmacology, EarlyView.
Abstract Vascular toxicity is a growing concern in cancer patients receiving vascular endothelial growth factor inhibitor (VEGFi) therapy, posing a significant threat to patient prognosis. While the primary mechanism of VEGFi‐induced vascular toxicity is linked to redox‐sensitive reactions that disrupt vascular tone, leading to hypertension and ...
Grace Whelan, Karla B. Neves
wiley   +1 more source

Pervasive food contaminant ochratoxin-A induces energy crisis: Mitochondrial dysfunction in human primary proximal tubule cells. [PDF]

Toxicol Rep
Mahadeo A, Bammler TK, MacDonald J, Zheng AR, Yeung CK, Himmelfarb J, Kelly EJ.   +6 more
europepmc   +1 more source

Handling of Drugs, Metabolites, and Uremic Toxins by Kidney Proximal Tubule Drug Transporters.

American Society of Nephrology. Clinical Journal, 2015
S. Nigam, Wei Wu, K. Bush, M. Hoenig, R. Blantz, V. Bhatnagar   +5 more
semanticscholar   +1 more source

Effects of Common Food Additives Kappa‐, Iota‐ and Lambda‐Carrageenans on Intestinal Epithelial Cell Activation and Barrier Disruption

Clinical &Experimental Allergy, EarlyView.
Carrageenans, widely used food additives, disrupted intestinal epithelial integrity in a gut‐on‐a‐chip model. All types (κ‐, ɩ‐, λ‐) induced cytotoxicity, inflammation and tight junction (TJ) disruption, triggering TNF‐mediated immune responses. λ‐Carrageenan had the most severe effects, supporting the Epithelial Barrier Theory linking food additives ...
Na Sun, Yagiz Pat, Huseyn Babayev, Sena Ardicli, Ismail Ogulur, Xianting Bu, Manru Li, Shuqi Jia, Beate Rückert, Raja Dhir, Kari C. Nadeau, Mubeccel Akdis, Cezmi A. Akdis, Duygu Yazici   +13 more
wiley   +1 more source

Soluble uric acid increases NALP3 inflammasome and interleukin-1β expression in human primary renal proximal tubule epithelial cells through the Toll-like receptor 4-mediated pathway.

International Journal of Molecular Medicine, 2015
Jing Xiao, Xiaoli Zhang, Chensheng Fu, R. Han, Weijun Chen, Yijun Lu, Zhibin Ye   +6 more
semanticscholar   +1 more source

Bridging Kidney Organoid Innovation and Regenerative Medicine: Current Advances and Future Directions

Cell Proliferation, EarlyView.
This review outlines kidney organoid differentiation strategies, key developmental mechanisms, and engineering and multi‐omics approaches driving their progress toward regenerative medicine. ABSTRACT Chronic kidney disease (CKD) has emerged as a critical public health challenge worldwide, and organ donor shortages underscore the urgent need for ...
Bohong Guo, Jingyuan Zhang, Xuening Fang, Yangyang Liu, Yueyang Deng, Yuxin Xue, Zhengxi Wang, Xiaotao Dong, Mengqi Jia, Xiaodong Li   +9 more
wiley   +1 more source

Rac1 promotes proximal tubule kidney repair by coupling the actin cytoskeleton to mitochondrial function. [PDF]

Proc Natl Acad Sci U S A
M Viquez O, Melzer M, Li S, Tantengco M, Dong X, Sha E, Huang J, Krystofiak ES, Hart RC, Luo W, Warren C, Bayazid AB, Zhang R, Bessho R, Haase VH, Brakebusch C, Inoue T, Brooks C, Wilson MH, Terker AS, Arroyo JP, Pozzi A, Zent R, Bock F.   +23 more
europepmc   +1 more source

Modeling oxygen consumption in the proximal tubule: effects of NHE and SGLT2 inhibition.

AJP - Renal Physiology, 2015
A. Layton, V. Vallon, A. Edwards
semanticscholar   +1 more source

Renal tubular acidosis in a mule mare

Equine Veterinary Education, EarlyView.
Summary Renal tubular acidosis (RTA) in horses is differentiated into type I (distal) and type II (proximal) forms. We report the diagnostic evaluation and treatment of type I RTA in a 13‐year‐old mule mare that was referred because of lethargy and inappetence of several weeks' duration as well as lack of manure, anorexia and mild colic for 3 days.
L. Kummer, K. Lohmann, C. Arnold
wiley   +1 more source