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functional ultrastructure of the proximal tubule
Comprehensive Physiology, 1992The sections in this article are: 1 Location of Proximal Tubule 2 Fixation of Proximal Tubule Cells for Electron Microscopy 3 Ultrastructure of the Mammalian Proximal Tubule Cell 3.1 General Cytology 3.2 Cell Shape 3.3 Segmentation of the Mammalian Proximal Tubule 3.4 Luminal Cell Surface 3.5 Basal and Lateral Cell ...
Maunsbach, Arvid B. +1 more
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Water Permeability in Rat Proximal Tubules
Acta Physiologica Scandinavica, 1970AbstractThe diffusional water permeability in rat proximal tubules was studied in microperfusion experiments with triturated water. The perfusion solutions were chosen either to give no net flux or a net water flux in either direction. The diffusional water permeability at zero net water flux was 564. 10‐‐5 cm/sec.
Erik G Persson, Hans R. Ulfendahl
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An equation for flow in the renal proximal tubule
Bulletin of Mathematical Biology, 1986Approximate equations for epithelial solute and water transport have been combined with the relations of mass conservation to yield a single differential equation representing volume flow along the proximal tubule. This flow equation is first order, quasilinear and may be integrated directly.
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Oxalate secretion in the rat proximal tubule
American Journal of Physiology-Renal Physiology, 1981Simultaneous capillary and luminal microperfusion studies in the proximal convoluted tubule of the rat were performed to examine the transepithelial secretory flux of [14C]oxalate. Increases in the concentration of oxalate in the capillary solution from 0.096 to 4.3 mM resulted in progressively higher rates of oxalate secretion into the lumen. Further
Harry O. Senekjian +3 more
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Ammonia Transport in the Proximal Tubule In Vivo
American Journal of Kidney Diseases, 1989Studies were performed to characterize the determinants of proximal tubule ammonia entry (and retention) in vivo. Rat proximal tubules were studied in vivo using in situ microperfusion. In both normal animals and animals with metabolic acidosis, increasing luminal flow rate significantly enhanced luminal ammonia entry.
L. Lee Hamm, E. E. Simon
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Nephrotoxicity and the Proximal Tubule
Nephron Physiology, 2003Cadmium (Cd<sup>2+</sup>) is a non-essential heavy metal, which is taken up from the environment into the body through pulmonary and enteral pathways. The S1 segment of the kidney proximal tubule (PT) is a major target of chronic Cd<sup>2+</sup> toxicity.
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Androgens stimulate proximal tubule transport
Gender Medicine, 2008Disrupting the enzyme cytochrome P4a14 in mice leads to hypertension, which is more severe in male than in female mice and appears to be due to androgen excess. Androgens are known to increase expression of angiotensinogen,but the effect of androgens on proximal tubule transport is unknown.These studies aimed to determine the effect of androgens on ...
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Androgens augment proximal tubule transport
American Journal of Physiology-Renal Physiology, 2004The proximal tubule contains an autonomous renin-angiotensin system that regulates transport independently of circulating angiotensin II. Androgens are known to increase expression of angiotensinogen, but the effect of androgens on proximal tubule transport is unknown.
Samer Loleh +8 more
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Proximal tubule response in aldosterone escape
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 1989The response of the proximal tubule to chronic aldosterone administration (15 micrograms.kg-1.day-1) was evaluated in eight conscious female mongrel dogs. Temporal profiles between hemodynamic and hormonal changes and the fractional excretions of sodium and lithium were established.
Franklyn G. Knox +5 more
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Ammonia Production and Secretion by the Proximal Tubule
American Journal of Kidney Diseases, 1989Ammonia production and secretion by the proximal tubule accounts for most of the ammonia that appears in the urine. Rates of ammonia production and net luminal ammonia secretion were measured in isolated perfused mouse proximal tubule segments. This approach combines the in vitro microperfusion technique with a sensitive bioluminescence assay for total
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