Results 271 to 280 of about 611,505 (395)

Role of RIPK1/RIPK3/MLKL signalling pathway in sepsis‐associated acute kidney injury

Experimental Physiology, EarlyView.
Abstract Sepsis‐associated acute kidney injury (SA‐AKI) is a common clinical syndrome in critically ill patients, and its high mortality rate is closely related to complex pathological mechanisms. Existing studies have shown that the pathophysiological process of SA‐AKI involves complex multi‐mechanism interactions, including an uncontrolled systemic ...
Huijun Yin, Jingyi Wang, Huirong Han
wiley   +1 more source

Proximal tubule-on-chip as a model for predicting cation transport and drug transporter dynamics. [PDF]

Sci Rep
Petit I, Faucher Q, Bernard JS, Giunchi P, Humeau A, Sauvage FL, Marquet P, Védrenne N, Di Meo F.   +8 more
europepmc   +1 more source

mTOR blockade prevents progressive proteinuria but induces hyperglycaemia in obese Dahl salt‐sensitive rats before puberty

Experimental Physiology, EarlyView.
Abstract Previous studies have demonstrated that mammalian target of rapamycin (mTOR) activity is significantly increased in the kidneys of Dahl salt‐sensitive (SS) rats during the development of renal injury. Therefore, in the present study we examined whether blockade of mTOR with rapamycin inhibits renal injury in Dahl salt‐sensitive leptin receptor
Sautan Mandal, Andrea K. Brown, Ubong S. Ekperikpe, Anukool A. Bhopatkar, Krystle M. Hughes, Tyler D. Johnson, Jonita S. Cooper, Konnor T. Wilbert, Denise C. Cornelius, Jan M. Williams   +9 more
wiley   +1 more source

GPX4 expression changes in proximal tubule cells highlight the role of ferroptosis in IgAN. [PDF]

Sci Rep
Qing J, Zhang L, Fan R, Zhi H, Li C, Li Y, Wu J, Han C, Li Y.   +8 more
europepmc   +1 more source

Lipotoxic disruption of NHE1 interaction with PI(4,5)P2 expedites proximal tubule apoptosis.

Journal of Clinical Investigation, 2014
Shenaz Khan, B. G. Abu Jawdeh, Monu Goel, W. Schilling, M. Parker, M. Puchowicz, S. Yadav, Raymond C. Harris, A. El-Meanawy, M. Hoshi, Krekwit Shinlapawittayatorn, I. Deschênes, E. Ficker, J. Schelling   +13 more
semanticscholar   +1 more source

Expression characteristics of dual‐specificity phosphatase 2 and hypoxia‐inducible factor‐1α in acute kidney injury and preliminary study of the effect of dual‐specificity phosphatase 2 on HK‐2 cells

Experimental Physiology, EarlyView.
ABSTRACT Acute kidney injury (AKI) is a global health problem with significant long‐term harm if the prognosis is poor. Dual‐specificity phosphatase 2 (DUSP2) is involved in key regulatory pathways in several disease processes, but its function in renal pathophysiology is unclear.
Xueqian Chu, Songmin Xue, Lanyan Lin, Xuan Huang, Sisi Chen, Wulaer Adeli, Zulibiya Tuohetiyaer, Suhua Li, Chen Lu   +8 more
wiley   +1 more source

Hemoglobin-associated <i>CALR</i> in proximal tubule cells can be used as a biomarker for idiopathic membranous nephropathy. [PDF]

Front Med (Lausanne)
Pang S, Tan Q, Xie B, Feng B, Zhou R, Liu Z, Wei H, Huang Y, Jili M, Xie Y, Li S, Zhao B, Li W, Yang R.   +13 more
europepmc   +1 more source

Maladaptive Proximal Tubule Repair: Cell Cycle Arrest

Nephron Clinical Practice, 2014
J. Bonventre
semanticscholar   +1 more source

Sodium–glucose cotransporter 2 inhibitors for hypertension in cardiovascular–kidney–metabolic syndrome

Experimental Physiology, EarlyView.
Abstract The antihypertensive mechanism of sodium–glucose cotransporter 2 (SGLT2) inhibitors has been traditionally attributed to osmotic diuresis. However, emerging evidence reveals multifaceted mechanisms beyond diuresis, including regulation of the renin–angiotensin–aldosterone system, sympathetic nervous system suppression, ion homeostasis ...
Chunxiang Xu, Xingyu Qiu, Nan Xu, Gensheng Zhang, Enyin Lai, Liang Zhao   +5 more
wiley   +1 more source

Proximal Tubule Secretory Clearance, Injury, and Kidney Viability in Cirrhosis. [PDF]

Clin Transl Gastroenterol
Granda ML, Luitweiler E, Prince DK, Allegretti AS, Paine C, Pichler R, Sibulesky L, Biggins SW, Kestenbaum B.   +8 more
europepmc   +1 more source