Results 281 to 290 of about 684,958 (347)

When NCX switches sides: Experimental and computational insights into Ca2+ regulation in the heart

The Journal of Physiology, EarlyView.
Abstract figure legend Due to its presence inside the dyadic cleft, Na+/Ca2+ exchanger (NCX) builds a functional unit together with L‐type calcium channels and ryanodine receptors in the dyadic cleft. NCX acts bidirectionally (forward and reverse mode) dependent on extracellular calcium ([Ca2+]o) and sodium ([Na+]o) concentrations and the membrane ...
Wilhelm Neubert, Judith Hüttemeister, Paulina Sander, Nagaiah Chamakuri, Felix Hohendanner, Martin Falcke, Frank R. Heinzel   +6 more
wiley   +1 more source

Crosstalk between endoplasmic reticulum stress and mitochondrial homeostasis: A new perspective on ophthalmic disease treatment

Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
The graphical abstract follows a top‐to‐bottom flow: stressors → ER–mitochondria crosstalk → ophthalmic diseases. The central panel highlights three core mitochondria‐associated membrane function axes, color‐coded as follows: light yellow for Ca2+ homeostasis, light blue for mitochondrial dynamics, and light red for mitophagy.
Luyang Jiang, Gongsang Cuomu, Sang Jijia, Yumei Yang, Jufen Liu, Yumin Tao   +5 more
wiley   +1 more source

Early endolysosomal dysfunction is a contributing factor to gadolinium-based contrast agent mouse renal proximal tubule epithelial cell injury. [PDF]

Cell Biol Toxicol
DeAguero J, Howard T, Escobar GP, Dokladny K, Wagner B.   +4 more
europepmc   +1 more source

Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies [PDF]

, 2019
Heath, Andrew C., Humphreys, Benjamin D., Madden, Pamela A. F., Wu, Haojia   +3 more
core   +1 more source

Association Between Glycemic Control and Complications With Concentration of Urinary Exfoliated Proximal Tubule Kidney Cells in People With Diabetes Mellitus. [PDF]

J Diabetes Res
Wu HHL, Bhagavath V, Nguyen LT, Chinnadurai R, Goldys EM, Pollock CA, Saad S.   +6 more
europepmc   +1 more source

Proximal tubule hypertrophy and hyperfunction: a novel pathophysiological feature in disease states. [PDF]

Clin Kidney J
Kanbay M, Copur S, Guldan M, Ozbek L, Hatipoglu A, Covic A, Mallamaci F, Zoccali C.   +7 more
europepmc   +1 more source

Acidosis-induced p38-kinase activation triggers an IL-6-mediated crosstalk of renal proximal tubule cells with fibroblasts leading to their inflammatory response. [PDF]

Cell Commun Signal
Schulz MC, Wolff N, Kopf M, Gekle M.
europepmc   +1 more source

Yapping at the autophagy door? The answer is flowing in the kidney proximal tubule. [PDF]

Autophagy
Claude-Taupin A, Terzi F, Codogno P, Dupont N.   +3 more
europepmc   +1 more source

Podocyte-specific KLF6 primes proximal tubule CaMK1D signaling to attenuate diabetic kidney disease. [PDF]

Nat Commun
Gujarati NA, Frimpong BO, Zaidi M, Bronstein R, Revelo MP, Haley JD, Kravets I, Guo Y, Mallipattu SK.   +8 more
europepmc   +1 more source

Pax proteins mediate segment-specific functions in proximal tubule survival and response to ischemic injury.

Am J Physiol Renal Physiol
McElliott MC, Telang AC, Ference-Salo JT, Al-Suraimi A, Chowdhury M, Otto EA, Soofi A, Dressler GR, Beamish JA.   +8 more
europepmc   +1 more source