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Ammonia Transport in the Proximal Tubule In Vivo

American Journal of Kidney Diseases, 1989
Studies were performed to characterize the determinants of proximal tubule ammonia entry (and retention) in vivo. Rat proximal tubules were studied in vivo using in situ microperfusion. In both normal animals and animals with metabolic acidosis, increasing luminal flow rate significantly enhanced luminal ammonia entry.
L L, Hamm, E E, Simon
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Calcium Transport by the Proximal Tubule

1986
Taken together the results of these in vivo microperfusion experiments indicate that calcium absorption by the proximal tubule depends on more than one transport mechanism. We have observed that net calcium flux is affected by changes in calcium ion activity (even with constant total calcium concentration) and in transepithelial voltage.
F S, Wright, K, Bomsztyk
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The Proximal Tubule

1994
The morphology of the proximal tubule cells was covered briefly in Chapter 2, but will be considered in more detail here. The proximal tubule is divisible into the convoluted portion, or pars convoluta, which begins immediately behind the glomerulus, and the straight portion, or pars recta, which passes into the medulla to become the loop of Henle. The
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Chloride Transport in the Proximal Renal Tubule

Annual Review of Physiology, 1988
Our knowledge of chloride transport along the nephron has greatly expanded. Whereas for a long time it was assumed that chloride ions were reabsorbed entirely passively with sodium--the "mendicant" role of chloride, more recent studies suggest that several distinct reabsorptive transport mechanisms operate in parallel.
L, Schild, G, Giebisch, R, Green
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The Proximal Tubule and the Podocyte in Cystinosis

Nephron, 1973
The belief that the swan-neck lesion or the Fanconi syndrome in cystinosis are related to the accumulation of cystine in epithelium of the proximal tubule is questioned.
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Water Permeability in Rat Proximal Tubules

Acta Physiologica Scandinavica, 1970
AbstractThe diffusional water permeability in rat proximal tubules was studied in microperfusion experiments with triturated water. The perfusion solutions were chosen either to give no net flux or a net water flux in either direction. The diffusional water permeability at zero net water flux was 564. 10‐‐5 cm/sec.
E, Persson, H R, Ulfendahl
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Nephrotoxicity and the Proximal Tubule

Nephron Physiology, 2003
Cadmium (Cd<sup>2+</sup>) is a non-essential heavy metal, which is taken up from the environment into the body through pulmonary and enteral pathways. The S1 segment of the kidney proximal tubule (PT) is a major target of chronic Cd<sup>2+</sup> toxicity.
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Androgens augment proximal tubule transport

American Journal of Physiology-Renal Physiology, 2004
The proximal tubule contains an autonomous renin-angiotensin system that regulates transport independently of circulating angiotensin II. Androgens are known to increase expression of angiotensinogen, but the effect of androgens on proximal tubule transport is unknown.
Albert, Quan   +8 more
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Androgens stimulate proximal tubule transport

Gender Medicine, 2008
Disrupting the enzyme cytochrome P4a14 in mice leads to hypertension, which is more severe in male than in female mice and appears to be due to androgen excess. Androgens are known to increase expression of angiotensinogen,but the effect of androgens on proximal tubule transport is unknown.These studies aimed to determine the effect of androgens on ...
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An equation for flow in the renal proximal tubule

Bulletin of Mathematical Biology, 1986
Approximate equations for epithelial solute and water transport have been combined with the relations of mass conservation to yield a single differential equation representing volume flow along the proximal tubule. This flow equation is first order, quasilinear and may be integrated directly.
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