Results 281 to 290 of about 93,932 (331)

Empagliflozin does not prevent progression of Dent's disease type 1 in a mouse model

Experimental Physiology, EarlyView.
Abstract Dent's disease is a rare inherited renal disorder characterized by generalized proximal tubule dysfunction with low molecular weight proteinuria, hypercalciuria, and urinary loss of other solutes. The disease is progressive and leads to chronic kidney disease.
Elise de Combiens, Nadia Frachon, Yohan Bignon, Marc Fila, Clément Brossard, Perrine Frère, Stéphane Lourdel   +6 more
wiley   +1 more source

Fluid shear stress-induced changes in megalin trafficking enhance endocytic capacity in proximal tubule cells. [PDF]

Front Physiol
Lackner EM, Cowan IA, Long KR, Weisz OA, Shipman KE.   +4 more
europepmc   +1 more source

Ouabain‐induced hypertension in rats: Mechanisms, variability and translational implications

Experimental Physiology, EarlyView.
Abstract Ouabain‐induced hypertension is a multifactorial and condition‐dependent phenomenon involving coordinated actions across vascular, renal and central nervous system pathways. At the vascular level, ouabain inhibits Na⁺/K⁺‐ATPase, particularly the α2‐isoform, leading to elevated intracellular Ca2⁺, enhanced vasoconstriction and structural ...
Priscilla Rodrigues O. Feijó, Luis Eduardo M. Quintas   +1 more
wiley   +1 more source

The synaptic vesicle cluster as a controller of pre‐ and postsynaptic structure and function

The Journal of Physiology, EarlyView.
Abstract figure legend The synaptic vesicle cluster acts as a master regulator of synaptic structure and function, through various involvements in processes that range from synaptic initiation to plasticity and synaptic loss. Abstract The synaptic vesicle cluster (SVC) is an essential component of chemical synapses, which provides neurotransmitter ...
Sofiia Reshetniak, Cristian A. Bogaciu, Stefan Bonn, Nils Brose, Benjamin H. Cooper, Elisa D'Este, Michael Fauth, Rubén Fernández‐Busnadiego, Maksims Fiosins, André Fischer, Svilen V. Georgiev, Stefan Jakobs, Stefan Klumpp, Sarah Köster, Felix Lange, Noa Lipstein, Victor Macarrón‐Palacios, Dragomir Milovanovic, Tobias Moser, Marcus Müller, Felipe Opazo, Tiago F. Outeiro, Constantin Pape, Viola Priesemann, Peter Rehling, Tim Salditt, Oliver Schlüter, Nadja Simeth, Claudia Steinem, Tatjana Tchumatchenko, Christian Tetzlaff, Marilyn Tirard, Henning Urlaub, Carolin Wichmann, Fred Wolf, Silvio O. Rizzoli   +35 more
wiley   +1 more source

Biogenesis and reformation of synaptic vesicles

The Journal of Physiology, EarlyView.
Abstract figure legend Synaptic vesicle proteins are axonally transported in precursor vesicles (PVs) before conversion into mature synaptic vesicles (SVs) that are reformed by local recycling at synapses. Abstract Communication within the nervous system relies on the calcium‐triggered release of neurotransmitter molecules by exocytosis of synaptic ...
Svenja Bolz, Volker Haucke
wiley   +1 more source

Inhibition of ErbB2 mitigates secondary denervation after traumatic muscle injury

The Journal of Physiology, EarlyView.
Abstract figure legend Our study evaluated the therapeutic potential of ErbB2 inhibition (Herceptin) after volumetric muscle loss (VML) injury, primarily evaluating improvements at the neuromuscular junctions (NMJ). A full thickness model of VML injury to the tibialis anterior muscle of adult Lewis rats was used, and treatments included Herceptin, a ...
Jacob R. Sorensen, Daniel B. Hoffman, Christiana J. Raymond‐Pope, Thomas J. Lillquist, Amanda M. Russell, Benjamin T. Corona, Sarah M. Greising   +6 more
wiley   +1 more source

Single cell multi-omics of fibrotic kidney reveal epigenetic regulation of antioxidation and apoptosis within proximal tubule. [PDF]

Cell Mol Life Sci
Chen Z, Ye L, Zhu M, Xia C, Fan J, Chen H, Li Z, Mou S.   +7 more
europepmc   +1 more source

The Complexities and Challenges of Managing Genetic Causes of Hyperphosphataemia, a Case Report

Journal of Paediatrics and Child Health, EarlyView.
Farrah Rodrigues, Paul L. Hofman, Catherine Quinlan, Margaret Zacharin   +3 more
wiley   +1 more source

Mechanisms underlying local Ca2+ signalling differences between right and left atrial myocytes at normal and increased frequencies

The Journal of Physiology, EarlyView.
Abstract figure legend Left atrial myocytes have TAT‐associated faster Ca2+ release but are more prone to maladaptation at higher frequencies due to weaker peripheral SR Ca2+ uptake and smaller trigger Ca2+ current. Abstract Changes in heart rate affect Ca2+ signalling and contractility in ventricular muscle, but the effects on atrial Ca2+ signalling ...
Joon‐Chul Kim, Hieu Trong Huynh, Phuong Kim Luong, Tran Nguyet Trinh, Yixuan Wu, Eleonora Grandi, Sun‐Hee Woo   +6 more
wiley   +1 more source

Mitophagy regulates mitochondrial number following pharmacological induction of mitochondrial biogenesis in renal proximal tubule cells. [PDF]

Front Pharmacol
Hurtado KA, Schnellmann RG.
europepmc   +1 more source