Results 31 to 40 of about 591,767 (375)
Ontogeny of proximal tubule acidification
The proximal tubule is responsible for the reabsorption of 80% of the filtered load of bicarbonate in adults. Proximal tubule bicarbonate reabsorption is affected by a number of hormones, acid-base balance, and the extracellular fluid volume status [1]. The adult proximal tubule thus plays a central role in acid-base homeostasis.
Michel Baum, Raymond Quigley
openaire +3 more sources
A modular and reusable model of epithelial transport in the proximal convoluted tubule.
We review a collection of published renal epithelial transport models, from which we build a consistent and reusable mathematical model able to reproduce many observations and predictions from the literature.
Leyla Noroozbabaee+3 more
doaj +1 more source
The role of renal proximal tubule transport in the regulation of blood pressure
The electrogenic sodium/bicarbonate cotransporter 1 (NBCe1) on the basolateral side of the renal proximal tubule plays a pivotal role in systemic acid-base homeostasis.
Shoko Horita+6 more
doaj +1 more source
Adaptive changes in GFR, tubular morphology, and transport in subtotal nephrectomized kidneys: modeling and analysis [PDF]
Removal of renal mass stimulates anatomical and functional adaptations in the surviving nephrons, including elevations in single-nephron glomerular filtration rate (SNGFR) and tubular hypertrophy. A goal of this study is to assess the extent to which the
Edwards, Aurelie+2 more
core +1 more source
Renal reabsorption in 3D vascularized proximal tubule models
Significance Current kidney-on-chip models lack the 3D geometry, complexity, and functionality vital for recapitulating in vivo renal tissue. We report the fabrication and perfusion of 3D vascularized proximal tubules embedded within an engineered ECM ...
N. Y. Lin+6 more
semanticscholar +1 more source
Transcriptional profiling of the zebrafish proximal tubule [PDF]
The hepatocyte nuclear factor-1β (Hnf1b) transcription factor is a key regulator of kidney tubule formation and is associated with a syndrome of renal cysts and early onset diabetes. To further our understanding of Hnf1b in the developing zebrafish kidney, we performed RNA sequencing analysis of proximal tubules from hnf1b-deficient larvae.
Veronika Sander+6 more
openaire +4 more sources
Heme oxygenase-1 mitigates ferroptosis in renal proximal tubule cells.
Ferroptosis is an iron-dependent form of regulated nonapoptotic cell death, which contributes to damage in models of acute kidney injury (AKI). Heme oxygenase-1 (HO-1) is a cytoprotective enzyme induced in response to cellular stress, and is protective ...
Oreoluwa O. Adedoyin+6 more
semanticscholar +1 more source
Peroxiredoxin1 (Prdx1) is an antioxidant enzyme belonging to the peroxiredoxin family of proteins. Prdx1 catalyzes the reduction of H2O2 and alkyl hydroperoxide and plays an important role in different biological processes.
Soomin Chae+19 more
doaj +1 more source
The mechanism of pathogenesis associated with APOL1 polymorphisms and risk for non-diabetic chronic kidney disease (CKD) is not fully understood. Prior studies have minimized a causal role for the circulating APOL1 protein, thus efforts to understand ...
Natalya A Blessing+9 more
doaj +1 more source
Inhalation of mercury vapor can cause the toxic effects on rat kidney [PDF]
Dental amalgam has been used in dentistry as a filling material. The filler comprises mercury (Hg). It is considered one of the most important and widespread environmental pollutants, which poses a serious potential threat for the humans and animals ...
Akgul, Hayati Murat+5 more
core +1 more source